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Objective To investigate the role of macrophage in asthma.

目的 研究单核-巨噬细胞在哮喘发病中的作用。

Methods: Mononuclear cells were obtained from human peripheral blood by the method of Ficoll-Hypaque density gradient centrifugation.

目的:观察白藜芦醇对人外周血单核/巨噬细胞CC型趋化因子受体5(CCR5)表达的调节作用。

However, little isknown about whether Candesartan can stabilize and reduce plaque disrupture bydecreasing the macrophage accumulation and reducing MMP-9 expression in the plaque,moreover, it is not clear about the effect of Telmisartan on AT1/AT2 receptor and MMP-9expression of monocyte-macrophages.

但ARB类药物坎地沙坦是否通过减少斑块内巨噬细胞聚集、降低MMP-9的表达从而稳定斑块并具有预防斑块破裂的作用,以及替米沙坦对单核/巨噬细胞AT1、AT2受体、MMP-9表达的作用如何,目前相关的实验研究较少。

HE staining and prussian blue staining in all transplantation mice were done and the result of the staining was analyzed. RESULTS: The macrophages were seen in the inner of 2 subcutaneous ectopia transplantation tumor models and the kupffer cells were found in the inner of 3 subcutaneous ectopia transplantation tumor models by Prussian blue staining.

结果: Prussian blue染色皮下移植瘤组有2只瘤鼠的瘤灶内见较为聚集的单核/巨噬细胞,肝脏移植瘤组中3只瘤鼠的瘤灶内见枯否细胞;肝脏移植瘤组见7个瘤灶与正常肝组织呈明显的浸润性生长。

Many studies have reported that Klebsiella pneumoniae is associated with ankylosing spondylitis but the mechanism of pathogenesis is remained unclear. The endoplasmic reticulum stress would be induced upon exposure of decapsulated KP in HLA-B27 expression B lymphoblast CA46 cells and non-HLA-B27 expression U937 monocytes. Our previous studies demonstrated that decapsulated KP could up-regulate BiP/Grp78 and calreticulin expressions in a dose- and time-dependent manner. We screen more than 60 kinds of traditional herbs and bioactivity agents and we found that berberine,taurine,extracts of Andrographis paniculata Nees.

许多研究指出克雷伯氏肺炎杆菌和僵直性脊椎炎有相当的关系,但是致病机制仍然不是很清楚,因此我们使用去荚膜克雷伯氏肺炎菌来诱发表现HLA-B27的CA46 B淋巴球母细胞、不含HLA-B27的U937单核球细胞可以产生内质网压力,我们先前的实验指出,随著剂量增加,去荚膜克雷伯菌能够过度调控内质网压力指标蛋白质BiP和Calreticulin表现增加。

GA(subscript 1+4) distribution in microspore mother cells, uninucleate and binucleate pollen, especially in nucleus, gradually increased with the anther development. Moreover, some GA(subscript 1+4) distributed in sperms.

短日照条件下花药可育,花粉母细胞、单核花粉和二核花粉内GA(下标 1+4)的分布数量逐浙增多,以细胞核最为明显;成熟花粉的精细胞内也有一定数量的GA(下标 1+4)分布。

2The distribution of HIF-1 a and COX-2 was unequal;.(3)These findings indicate that HIF-1a and COX-2 may be two important factors in pulpal lesions and there is a significantly hypoxia condiction in inflamed pulp .(4)The increase of HIF-1 a is a possible mechanism for hypoxia preconditioning .(5)Our results suggested that pulpal fibroblasts as well as macrophages might be involved in the pathogenesis of irreversible pulpitis.

和COX一2的表达均有不同程度的变化,在牙髓炎病程中可能发挥着重要的生理和病理作用,③在牙髓炎进程中和牙髓自身修复过程中存在着缺氧环境和缺氧耐受机制,④牙髓成纤维细胞有可能与单核巨噬细胞一同参与牙髓炎的病理进程,且具有修复和免疫功能。

We compared the ability of primitive and monocytic endothelial cell progenitors to stimulate vascular growth and healing in diabetes and investigated potential molecular mechanisms through which the cells mediate their in vivo effects.

我们在糖尿病模型中比较原始和单核系上皮祖细胞在刺激血管形成和愈合中的能力,从而根据细胞在活体内的自我调节调查其潜在的分子机制。

During bacterial infection, monocytes will differentiate into macrophages that can phagocytize the pathogens neutralize the toxins and play a critical role in inflammatory responses.

当细菌侵入时,由单核球分化而来的巨噬细胞会透过吞噬作用将这些危害人体的毒素吞入,裂解并消灭之,因此巨噬细胞在细菌引发的发炎反应中扮演著非常重要的角色。

This preliminary case control study reconfirms that TWHf is a very potent herbal remedy to suppress mononuclear expressions of many inflammatory cytokines and pro-inflammatory molecules.

尽管只有少数的研究对象,本篇研究提供了在免疫致病机转上的可能证据来支持雷公藤对於僵直性脊椎炎患者周边血液单核球细胞内的许多发炎性细胞激素及其它和发炎反应有关的分子的基因表现具有强烈的抑制作用的说法。

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