单核细胞性的

Results First, locomotor activity , total and differential leukocytecount as well as serum level of IgG in mice were distinct with different light-dark cycles except for acidophile and monocyte count .

结果 (1)不同的光暗循环周期下，除嗜酸性和单核细胞外，小鼠活动性、白细胞计数及分类、血清IgG的大小不同。

We show in vivo that monocytes are recruited avidly to plaques within days of adoptive transfer.

我们发现在体的单核细胞于过继性转移的几天内向粥样斑块迅速地聚集。

Methods Monocytes were isolated from peripheral blood of coronary heart disease cases by FicollHypaque density gradient centrifugation.

目的 建立人单核源性泡沫细胞的疾病模型，为动脉粥样硬化的发生发展机制及其防治研究提供新途径。

Objective To investigate T-bet mRNA expression on peripheral blood mononuclear cells and its relations with allergen specific IgE, eosinophile cationic protein levels, and allergic symptom in patients with allergic rhinitis.

目的 探讨变应性鼻炎患者中外周血单核细胞中T-bet mRNA的表达及其与特异性IgE、患者症状和嗜酸性粒细胞阳离子蛋白的关系。

However, in SLE patients with leucopenia, the telomere length of MNC was significantly shorter than that of PMN.

然而在白血球减少的红斑性狼疮病人，其周边血液单核细胞终端体长度的确较多形核嗜中性白血球终端体长度显著地短。

The mice inoculated with Coxiella burnetii intrana- sally developed interstitial pneumonia,while the primary pathological changes of mice inoculated intraperitoneally are granulomas in spleen and liver.2.The pathological changes became more severe followed the dosage increasing.3.Coxiella burnetii can be detected in spleen and liver at day 2 after inoculation.the lesion became more and more serious from day 2 to day 12.The characteristic changes were observed at day 7,and recovered at day 14. 4.The reticuloendothelial system are main target of Coxiella burnetii.The pathogen was detected in cytoplasm of monocyte -macrophages of spleen, liver, lung, and endothelioid cells of blood vessel. 5. Coxiella burnetii can be found in macrophages lysosomes by electron microscopy. Most of them are round or rod, and polymorphic shape can also be observed in different size.

结果：1、通过不同感染途径的实验证实，滴鼻感染的小鼠主要表现为间质性肺炎，而腹腔注射感染小鼠则以脾脏、肝脏肉芽肿为主要病变。2、通过不同剂量的感染实验发现，随着感染Q热立克次体剂量的加大，动物病变愈加严重。3、通过感染后不同时间的动态病理学观察发现，在腹腔注射后第2d的脾和肝脏即可发现病原体，主要脏器的病理变化从第2d到第12d逐渐加重，第7d动物的病变最典型，至感染后14d动物的受损器官已开始出现修复性变化。4、 Q热立克次体主要侵害机体的网状内皮系统，在感染小鼠的肝、脾、肺和外周血管单核巨噬细胞以及血管内皮细胞胞浆中查见病原体。5、透射电镜观察可见Q热立克次体主要位于巨噬细胞吞噬溶酶体内，呈多形性，多见圆形和杆状，大小不一。

Methods and Results— Using a micro–single-photon emission computed tomography small-animal imaging system and a Food and Drug Administration–approved radiotracer ([indium 111] oxyquinoline, 111In-oxine), we demonstrate here that monocyte recruitment to atherosclerotic lesions can be visualized in a noninvasive, dynamic, and 3-dimensional fashion in live animals.

方法和结果——采用微单光子发射计算机断层摄影术的小动物成像系统和美国食品药品治理局认同的放射性示踪剂（111In-oxine），我们证实动物体内单核细胞向动脉粥样硬化损害处的聚集能够通过一种非侵入性，动态的，3维方式进行可视化观察。

Methods and Results-Using a micro-single-photon emission computed tomography small-animal imaging system and a Food and Drug Administration-approved radiotracer [indium 111] oxyquinoline,(111In-oxine, we demonstrate here that monocyte recruitment to atherosclerotic lesions can be visualized in a noninvasive, dynamic, and 3-dimensional fashion in live animals.

方法和结果：我们通过Micro-SPECT小动物显像系统和FDA批准的示踪剂（铟111-羟化喹啉），证实单核细胞向AS病变处募集过程可以被非侵入性影像技术动态、三维模式观察到。

The histopathologic changes included lymphocyte and monocyte infiltration,hyperplasia of synovial cells and small vessels,interstitial fibrosis,hyaline degeneration and cartilaginous metaplasia.The immunohistochemical observations showed that the high expressions of IL-1 and IL-6 were significantly different between the pathologic plicae and the control groups（P＜0.01）.The positive expressions of IL-1 and IL-6 were the synovial cells and monocyt-lymph cells in the pathologic synovial plicae.The positive expressions of MMP-1 and TIMP-1 have significant difference between the experiment and control group（P＜0.01,P＜0.05）.The expression of MMP-1 was positive in synovial lining cell,monocyte,fibroblast,endothelial cell in small vessel and chondrocyte.The TIMP-1 expression was detected in the synovial lining cells and a small quantity fibroblast.

结果 正常滑膜皱襞和病理性滑膜皱襞在滑膜细胞增生及小血管增生、间质纤维化及玻璃样变、软骨化生组织学改变方面，差异均有显著性（P＜0.01）；IL-1、IL-6在病理性滑膜皱襞内的增生滑膜细胞、单核及淋巴细胞和在正常滑膜皱襞内的表达差异均有显著性（P＜0.01）； MMP-1、TIMP-1在病理性滑膜皱襞和正常皱襞内的阳性表达，差异具有显著性（P＜0.01，P＜0.05），MMP-1在增生滑膜衬里层细胞、单核和纤维母细胞、血管内皮细胞和软骨化生的软骨细胞呈阳性表达；TIMP-1只在滑膜衬里层细胞和少量纤维母细胞有表达。

The membrane lipid fluidity of infected cells appeared obviously low-There were significant differences statistically(p.05-0.01)(2)By cytohisto-chemical stain-ing and microspectrophotometer quantitating,before cultured 72 hours,ACP and SDH in infectedcells raised.

动态观察1、6、24、72h培养后的淋巴细胞、单核细胞、中性粒细胞，发现感染后细胞膜脂的流动性明显降低，并随培养时间的延长而明显，和正常对照组比较有显著性差异（P＜0.05～0.01）。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。