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Positive association were still remained for two locus that MNAT1-rs973063 and PCNA-rs25406 and lung cancer risk even after 1000 times permutation test.During the stratified analysis,we revealed that that several genes in the NER pathway could interact with age,gender,family cancer history and smoking status.

在进行了多重校正后,有两个位点仍显示出关联显著性:MNAT1-rs973063(p=0.02),PCNA-rs25406(p=0.03);在随后进行的分层分析中,我们发现NER通路多个基因分别和年龄、性别、肿瘤家族史以及吸烟状况之间存在互作,提示该通路基因位点可能主要是通过和环境交互作用产生效应;我们还进行了单倍型的分析,结果发现PCNA和RPA1两个基因上的单倍型和肺癌易感性相关。

The 96 haplotypes were compared with 91 sheep D-loop sequences from Genebank, the results showed that Mouflon and haplotypes B clustered together, this indicated that Mouflon had very close relation to Chinese domestic sheep .

从Genebank获得的91个绵羊 D-环序列和中国的96个绵羊 D-环单倍型序列研究表明,摩佛伦与单倍型B聚为一类,说明摩佛伦与中国家养绵羊具有很近的亲缘关系。

By 1937 Zeiss listed about 20 high quality monocular, binocular and stereo microscope configurations in their literature. And they also marketed a wide selection of optional attachments and illuminators including at least 33 objectives of from 2X to 120X, and about 20 eyepieces of Huygens, Orthoscopic, and Compensating designs of from 3X to 30X.

1937年,蔡司文献上就已经有了大约20种高品质单目望远镜、双目望远镜和立体显微镜,并且还有很多可选的光学配件,说明书中列出了至少33种2倍到120倍物镜(其中包括6种为使用萤石型),至少大约20种3倍到30倍的惠更斯型,无畸变型(直线型Orthoscopic),和补偿型目镜。

Results:The reversal effectiveness of the modulator combinations was 2-3 times as much as that of each modulator alone.Synergistic interaction between Quin and DPM or Tam was greater than that between Quin and CsA.Quin combined with CsA increased intracellular DNR accumulation significantly as compared with either of them alone.

结果:逆转倍数是单用药的2-3倍,达到或超过单用2倍剂量的逆转效果,逆转剂间有联合协同作用,其中Quin与DPM或Tam联合的协同作用大于Quin与CsA联合,可增加细胞内DNR浓度。

Meanwhile, we identified the representative haplotypes of which the tag SNP would be on behalf of every haplotype block.

同时,确定了单倍域内的标签SNPs分别代表的单倍型。

Therefore, Y haplogrouping is highly recommended for studies on Y-linked disease, such as spermatogenic failure.

对Y染色体的单倍群分型后发现,AZFc的各类结构变化在各单倍群中的分布差异较大。

The average sequence divergence between individuals was 0.0006, while the range within a population and between populations were both 0-0.0013. Fst values were 0.0704, 0.0491, and 0.0792 for Cox1, ND1, and the combination of both genes. These data showed significant genetic variances (P.05) among geographic populations. The taimen populations in Heilongjiang River could be divided into four subpopulations based on Fst values between these geographic populations. However, these populations shared one common haplotype (BH11) shown by haplotype network and haplotype distribution frequency analysis. This suggested that they evolved from a common ancestor (likely a population in the upstream of the Heilongjiang river) and shared common gene flows.

单倍型网络和AMOVA分析结果均表明黑龙江流域哲罗鲑存在显著的群体分化,Cox1基因、ND1基因及组合数据的群体间Fst分别为0.0704、0.0491、0.0792,均达到显著性水平(P.05),根据配对群体间Fst可以将黑龙江流域哲罗鲑群体分为黑龙江上游群体、呼玛河群体、乌苏里江群体、内蒙古伊敏河上游群体4个地理群。9个群体共享同一个单倍型(BH11),表明这些群体具有相同的演化历史,为同一个祖先群体演化而来。

Model test shows that when raft is the principal bearing element, a single pile with cap has nearly the same behavior with a corresponding unpiled raft when subjected to vertical load. When the load acting on the pile cap exceeds the ultimate pile load, the pile carries less load than it's ultimate pile load. When the load exceeds 2 times of the ultimate pile load, pile is nearly at full capacity.

一、进行了室内模型试验,证明当以桩间土为主承担荷载时,带台单桩的荷载~沉降特性与天然地基上浅基础类似;当外荷载超过单桩极限承载力时单桩并不达到极限承载力,当外荷载超过2倍单桩极限承载力时桩顶反力才接近单桩极限承载力;此后加载台下单桩以接近极限承载力的状态继续承担外荷载。

These data indicate a high level of genetic diversity in the Yarkand hare.

全部样品中定义了19个单倍型,每个种群都显示了很高的单倍型多态性。

Mitochondrial cytochrome b sequence were used to study the molecular evolution and phylogeny of Anser cygnoides(15 breed of Chinese goose), Anser anser(2 breed of domestic European goose) and Anser albifrons(the lesser white-fronted goose, Genbank accession number AF363031). Sequence analysis revealed that there were 29 variable sites and 4 haplotypes in 45 sequences, nucleotide diversity and haplotype diversity were 0.0068,0.45 respectively, insertion/deletion or frameshift mutation were not found in Cyt-b gene sequences(1143bp).

本实验测定了中国家鹅15个品种、欧洲鹅2个品种共44个个体的细胞色素b基因全序列,与Genbank库中自额雁细胞色素b基因序列合并在一起比对分析,17个家鹅品种和白额雁细胞色素b基因全序列均为1143bp,序列中没有缺失、插入或移码突变,共检测到29个变异位点、4种单倍型,核苷酸多样度和单倍型多样度分别为0.00648和0.45。

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