单作用

Based on the petrological and geochronological study of metamorphic complexes from the Grove Mountains, the following conclusions are reached.(1)Exsolution texture is widely found in clinopyroxene in mafic granulites. A peak metamorphic temperature of 850 C was obtained from the reintegrated compositions of exsolved clinopyroxene. The preservation of augite megacrysts suggests a single episode of high-grade metamorphism for the Grove Mountains.(2)The compositional comparison of garnet from pegmatites with that from country rocks demonstrates that garnet in pegmatites is of xenocryst origin, and late amphibolite facies metamorphism does not occur in this area.(3)The Pan-African charnockite and post-tectonic sheet-like granite were first recognized in East Antarctica. Their occurrences suggest a collisional orogeny during the Pan-African time.(4)The SHRIMP U-Pb zircon dating on various rock types indicates that the major metamorphism in the Grove Mountains occurs at c. 550 Ma, and the tectonothermal evolution terminated at c. 500 Ma. The Grenvillian granulite facies metamorphism did not develop in the studied area.(5)The Prydz belt, the second Pan-African suture within the Gondwana suppercontinent, was further comfirmed based on this study. The Gondwana suppercontinent was not formed by the simply juxtaposition of East and West Gondwana, but by the collision of several blocks during the Pan-African time.

本项目通过格罗夫山地区高级变质杂岩的变质岩石学和同位素年代学研究，获得如下重要认识：（1）发现辉石出溶结构，由此获得峰期变质温度为850 C，并根据火成普通辉石的识别确定该区只存在单相麻粒岩相变质；（2）通过伟晶岩中石榴石斑晶与围岩中石榴石的对比研究提出了石榴石的捕虏晶成因，进而确定该区不存在晚期角闪岩相变质作用；（3）在东南极首次识别出泛非期紫苏花岗岩和后构造层状花岗岩，为泛非构造热事件的碰撞造山成因提供了重要佐证；（4）对不同岩石类型的锆石SHRIMP定年精确地限定了格罗夫山地区主期变质作用发生于泛非期，～550 Ma，热事件结束于～500 Ma，年代学数据没有揭示在该区存在格林威尔期麻粒岩相变质作用的迹象；（5）进一步确认了东南极内部普里兹带的存在，它属于冈瓦纳超大陆内部的第二条泛非期缝合带，据此认为冈瓦纳超大陆并不是由东、西冈瓦纳陆块的简单拼合而成，而是多个不同块体拼合的结果。

MICs of the combination of cefoperazone or ceftazidime and levofloxacin were determined by the microdilution chequer board technique,interpretation of the results was made by calculation of FIC.

结果：头孢哌酮、头孢他啶和左氧氟沙星联合用药对铜绿假单胞菌的体外抗菌协同作用为35 5%～38 7％，相加作用为41 9%～45 2％，无关作用为16 1%～22 6％，无拮抗效应。

By collecting ,testing, comparing, and analyzing the soil samples, soil recovery under the various recovery conditions along Mian CountyNingqiang highway was studied. The results were as follows herbaceous recovery to the soil fertility recovery in the prior was greater than the combination of grass and irrigation or than the pure bushes recovery. In each of them, the content of organic matter were 13.84, 7.50, 6.00 g·kg-1; In the recovery of herbaceous ecology, to grow leguminous plant and granminaceous plant together was better than pure graninaceous plant or pure leguminous plant. In each of them, the content of organic matter was 29.67, 17.51, 9.37 g·kg-1; to sow ryegrass and alfalfa together with some local grass seeds or to grow coxcomb, alfalfa and local couch grass together could bring better effects than to plant the alfalfa only. In each of them the increased organic matter contents were 4.93,17.51 and 9.37 g·kg-1;the quotas of the organic matter and alkaline hydrolysis nitrogen in soil fetility factor were closely connected, mainly because of the difference between the generation quantity and resolution quantity of the organic matter in the soil surface.

采集土壤样品，经室内分析化验，用对比分析的方法对勉县至宁强高速公路生态恢复中不同恢复类型条件下的土壤恢复进行了研究，结果表明草本恢复类型对前期土壤肥力的恢复作用大于草灌结合，并大于单纯灌木恢复类型，其中有机质含量分别为13.84、7.50和6.00 g·kg-1；在草本生态恢复类型中，豆科植物与禾本科植物混播恢复类型大于禾本科植物恢复类型的作用，并大于单纯豆科植物恢复类型的作用，其中有机质含量分别为29.67、17.51和9.37 g·kg-1；黑麦草与苜蓿混播并有当地草种入侵以及小冠花与苜蓿混播并播入当地草种羊茅，明显优于纯苜蓿单播，其中有机质含量分别增加了4.93和3.32 g·kg-1；土壤肥力因子中有机质与碱解氮两个指标有较好的相关性，主要与土壤表层有机质的生成量和分解量之差有关。

Five models were used to investigate the "Changdong"" s anti-tumor effect: mice S180 sarcoma solid model, mice liver cancer H22 solid model, mice Lewis lung cancer model, as well as human liver cancer QGY and colon cancer LOVO implanted in naked mice; mice liver cancer H22 was also used to evaluate the enhancive effect of "Changdong" when it was co-applied with other anti-tumor agent or with radiotherapy; The "Changdong"" s cytotoxic effect in vitro on such tumors as QGY, LOVO, lung cancer A549, breast cancer MCF-7, as well as mice leukemia P388 was observed through MTT method. And investigate the effect of "Changdong" on proliferation of spleen lymphocyte, on activity of NK cell and on synthesis of IL-2 in mice bearing Lewis lung cancer, respectively. With propidium iodide straining, cell aigptosis and cell circle were analyzed by flow cytometry. Result:"Changdong" has an evident tumor inhibitive effect on mice tumor model as well as human tumor implanted in naked mice with a quantity-effect relationship.

使用小鼠S180肉瘤、小鼠肝癌H22实体瘤和小鼠Lewis肺癌模型，以及人体肝癌QGY和人体肠癌LOVO裸鼠异种移植模型，进行"长动"的抗肿瘤药效学研究：用小鼠肝癌H22进行"长动"合并放疗和化疗的增效作用研究；用MTT法进行"长动"对肝癌QGY、肠癌LOVO、肺癌A549、乳腺癌MCF-7、小鼠白血病P388等10株人体和动物肿瘤细胞的体外细胞毒性作用研究；用淋巴细胞转化试验、小鼠NK细胞活性试验、小鼠胸腺细胞增殖法分别测定"长动"对荷Lewis肺癌小鼠的脾淋巴细胞增殖的影响、自然杀伤细胞活性的影响和对小鼠产生白介素-2(IL-2)的影响；用流式细胞仪PI单染色法进行"长动"对人体肝癌QGY细胞的体外诱导凋亡作用和对肿瘤细胞周期的影响的研究。

Results showed that L-THP possessed negative inotropic and negative chronotropic action, lowed left ventricular pressure and it's infinitesimal calculus, decreased heart output in per min., shorten 〓 and 〓 of action potential of ventricular papillary muscle of guinea pig and even the plate-phase of action potential disappeared in larger dose group , but prolonged 〓. we studied transmembrane transportation of 〓 after administering L-THP , L-THP not only depressed uptake and increased release of Ca 2+ in normal myocardium, but also it showed stronger inhibition in cell injured by ISO, and fully eliminated the effect of ISO increasing uptake and decreasing release of 〓. By detecting the 〓 content of ventricular single myocyte using fluorescent probe Fluo-3/AM, results correspond to that done above, L-THP decreased 〓 content inside of cell significantly. Using whole-cell mode, we observed the effect of L-THP on Ica in ventricular single cell, it was found that L-THP decreased Ica, the effect increased with increasing it's dose, and had voltage, frequency-dependency. Dose highly corelated to effect, corelative constant is 0.87. When washing cell with normal tyre's solution, Ica could recover, which proved the blocked action of L-THP on calcium channel once again. Meanwhile, L-THP reduced production of MDA in heart injured by ISO in dose-dependent manner, improved content of GSH-Px, in case tissue or cell free from free radical damage.

结果显示，该药物具有负性肌力和负性频率作用，降低左室压及其微分，终使每分心输出量减少；缩短豚鼠心室乳头肌动作电位时程的〓和APD〓，大剂量使动作电位平台消失，〓延长；同位素示踪法研究证实L-THP抑制〓摄取，促进〓释放，降低细胞内的〓含量；单通道水平的研究证实，L-THP减少豚鼠心室肌单细胞内向钙电流，且具有剂量，电压，频率依赖性，其作用易于洗脱，药物剂量与Ica也具有高度相关性（相关系数r为-0.87）；L-THP还可抑制ISO损伤心肌组织所致的丙二醛含量增加，增加谷胱甘肽过氧化物酶的量，使组织细胞免受损伤。L-THP阻断L-型〓通道，抑制〓的摄取，促进〓的释放，降低细胞内〓含量L-THP作用的离子基础。

Currently activities involve (1) Investigation of dye-DNA interaction by using spectroscopic methods to probe the binding sites between chromophore and DNA and to identify various DNA conformational structures, particularly the telomeric DNA;(2) Investigation of the structure-activity correlation of anti-telomerase agents;(3) Design and synthesis new compounds for antitumor agents and fluorescence biomarkers;(4) Monitoring the folding and unfolding of quadruplex structure, tracing the pathway of drug delivery and probing drug-target interaction by using single molecule microscopy and spectroscopy.

目前 的研究重点分别是(1)利用光谱方法探讨探针分子与DNA的交互作用，特别是作用位置与结构变化；(2)研究抗端粒酵素作用分子之结构与生物活性之关系；(3)设计及合成抗肿瘤药剂或萤光生物标记；(4)建立单分子萤光光谱与影像技术，研究 DNA的多变型结构之变化机制，监测药物输送的路径过程及其在细胞中与标的物的作用。

5Researches show that changes of resistivity,temperature,pressure and deformationduring freezing-thawing cycles are real-time and synchronical,which proves that it is feasibleto study the changes of soil structure during freezing-thawing and problem of strength-deformation under external load by using electrical resistivity method.

5通过单轴载荷与冻融作用下冻土电阻率特性试验研究表明土体电阻率与应力-应变关系、正冻正融过程以及土体温度的变化具有很好的同步性，说明利用电阻率实时观测的方法研究冻融循环过程、冻融作用对土体结构影响以及载荷作用下土体强度与变形问题是可行的

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Simian3 and Shiyuan321 as control. It showed that both GK12 and SGK321 had no significant impacts on natural control efficacy of the biological and non-biological death factors of cotton aphids. Except for the factor of natural death and others, predation was the key factor affecting population dynamics of cotton aphid. Rain ranked the second, parasitism by insects and pathogens had weak control efficacy.

与常规棉相比，单，双价抗虫棉对天敌捕食和寄生，病原物，风雨等生物和非生物因素对棉蚜种群的自然控制作用均未产生显著影响；各因素中，除自然死亡及未知因素死亡外，天敌捕食对棉蚜自然种群的控制作用最强，风雨的作用次之，天敌寄生和病原物的作用则较弱。

For the first time, a screw pile and pile driver system for preventing flood and rushing to deal with an emergency was manufactured. The screw piles of the system is different from screw drills used to sap, and it doesn't push soils out. Analyses, including the screw pile's structural strength analysis and the screw blade's welding analysis, were done by ANSYS, which showed that the screw pile's structural strength is enough and that the distort of the screw blade is small. Testing on the screw pile and pile driver system showed that the system performed stably and could meet the need of preventing flood and rushing to deal with an emergency. A mechanics model of interaction of a screw pile and soil was built, and expressions of torque of screw pile's cylindrical part on the condition of screw pile's crew part being driven into soil fully were gained, then the relation of the torque with screw pitch and out diameter of cylinder, which shows the torque decreases with the screw pitch increasing, and that the torque increases with the out diameter of cylinder increasing, which was according with the experiments of the screw pile's being driven into soils, and thus a screw pile with the best structure was chosen. Experiments of bionic surface showed that, on the condition of certain pressure on the surface, the protruding bionic surface can not reduce adhesion and resistance and that the corrugated bionic surface can reduce adhesion and resistance. An orthogonal experiment of the corrugated bionic surface was done with the factors including the width of protrusion, the space between two protrusions, the trolley's velocity and the vertical surface pressure and with the surface frictional coefficient as the experimental target, and some inclusions were drawn that the best combination of the factors was acquired and that the width of protrusion affected the surface frictional coefficient remarkably.

研制了防汛抢险螺旋桩机系统，提高了沉桩作业效率；利用ANSYS对桩体进行整体结构强度分析以及螺旋叶片的焊接分析，表明桩体结构强度足够，焊接过程中，螺旋叶片的变形小；对整个螺旋桩机系统进行试验，表明该系统性能可靠，工作稳定，作业效率高，能够满足防汛抢险沉桩作业基本需要；建立了螺旋桩桩土作用力学模型，得出螺旋桩沉桩过程中螺旋桩螺旋部分完全进入土体时螺旋桩圆柱部分所受扭矩以及扭矩与防汛抢险螺旋桩的螺旋导程和圆柱外径的关系曲线，表明螺旋桩螺旋部分完全进入土体时螺旋桩圆柱部分所受扭矩随着螺旋导程的增大而减小，随着圆柱外径的增大而增大，这与螺旋桩沉桩试验结论相符合，据此优选出最佳结构的螺旋桩；仿生曲面试验表明，尺寸较小的球冠突起型仿生曲面在一定压力作用下未能起到减粘降阻的作用，而尺寸较大的波纹型仿生曲面相对平板具有一定的减粘降阻作用；以波纹型仿生曲面突起宽度、波纹型仿生曲面两突起之间间距、台车的牵引速度以及叶片表面垂直载荷为因素，以曲面摩擦系数试验指标进行正交试验，寻求出在一定试验条件下最佳因素水平组合；波纹型仿生曲面突起宽度在本试验条件下对曲面摩擦系数影响显著，而其它几个因素对曲面摩擦系数影响均不显著；通过波纹型仿生曲面突起宽度和台车牵引速度的单因素试验，表明曲面摩擦系数随着仿生曲面突起宽度的增大而减小，而随着台车牵引速度的变化基本保持不变，和正交试验结果保持一致。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。