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We further evaluated the synergistic cytotoxicity of TRAIL in combination with actinomycin D, cisplatin and paclitaxel in A549 cell lines in vitro and in vivo.

本实验选择了人肺腺癌A549细胞瘤株作为我们实验研究的对象,通过TRAIL对人肺腺癌A549细胞诱导凋亡研究,在A549的荷瘤裸鼠的动物模型上研究了其体内的抗肿瘤活性,并进一步研究了TRAIL与化疗药物放线菌素D(actinomycin D,Act D)、紫杉醇和顺铂(cisplatin,CDDP)的联合作用对人肺腺癌A549细胞的体外协同抗肿瘤活性,通过化疗药物协同增强TRAIL抗肿瘤活性作用机制的初步研究,为降低临床化疗药的用药量,减轻其对机体的不良反应提供一定的理论基础。

To completely meet the needs of Internet-based collaborative work, we propose a novel architecture to implement a process-oriented remote feature-based modeling on Web. Synchronal collaborative work, user management, group control, activity chain and electronic appointment using mobile aglet are key points to enable this tool. Finally, an example is given to illustrate how the tool is being used.

为满足基于Internet的协同工作需要,本文介绍了一种利用新的设计工具的新颖的设计方法,提出了一个基于Web的过程驱动的远程特征建模工具的体系结构,同步协同工作、用户管理、活动链及基于移动智能的电子预约是本系统的关键技术,最后用一个实例说明了系统的运行过程。

Compared with traditional invasion detection system has a lot of advantages to invade the detection system distributed: Distributed IDS is that a lot of measures the land to different data sources, adopts different measuring algorithms, measure together, cooperate and deal with, has improved the accuracy measured ; But distributed IDS can be used in the extensive network environment; Distributed IDS may use the special package to be punish and audit datum safely, help the system to be produced and invade the rule of measuring and produce and unusually measure models ; Distributed IDS analyses the behaviors of a lot of control points in coordination, may measure out and attack distributed in coordination ; The measuring of distributed IDS right a certain control point can be regarded as the early warning of other check points .

分布式入侵检测系统跟传统的入侵检测系统相比有很多优点:分布式IDS是多个检测域针对不同的数据来源,采用不同的检测算法,共同检测,协作处理,提高了检测的准确性;分布式IDS却可以用于大规模的网络环境;分布式IDS可以使用专门的组件处理安全审计数据,帮助系统生成入侵检测规则和生成异常检测模型;分布式IDS协同分析多个监控点的行为,就可能检测出分布式协同攻击;分布式IDS对某个监控点的检测可以作为对其他检测点的预警。

An artificial method of constrained coassembling process plan based on VRML model includes setting slide – rotary connection constraint; selecting artificial assembling body model; confirming constraint type of each component to its front or back end component in open or closed loop mechanism; calculating translation and rotary matrix of each component in moving course and its position parameter; generating time – order – path matrix and key frame as per time section; writing each key frame in reverse mode into interpolator of each component VRMC model; adding route in sequence between time and position sensors, position sensor and component form node for generating artificial picture.

本发明属于CAD协同产品设计技术领域,其特征在于:在网络环境下,设计者依托装在节点机上的三维VRML模型,以设计者与设计场景交互方式按照以下步骤实现有约束协同装配工艺规划:设定滑动转动联接约束;选定仿真装配体模型;确定开环或闭环机构中各零部件与它的前端和后端部件的约束类型;计算各零部件在运动过程中的平移和转动矩阵,再根据相应的约束计算运动过程中各零部件的位置参数;再据此生成零部件的时间-顺序-路径矩阵,按时间段形成关键帧;把各关键帧分别以逆序写入VRML各部件模型的插补器,依次在时间传感器和位置传感器之间、位置传感器和零部件造型节点间加入路由,生成仿真画面。

Meantime, the transparent ZnO electrode reduced the spatial separation between the liquid and the underlying electrode, and effectively photoelectric cooperative wetting occurred, with the surface changing from low adhesive to adhesive, which is propitious to develop in this field, such as the feasibility of the patterned photoelectric cooperative wetting, namely, applying a bias lower than the electrowetting threshold voltage, photoelectric cooperative wetting can be realized only at the illumination site, i.e., patterned site.

这一研究有利于拓展这一领域的发展,为开发新型的协同响应的功能浸润性界面材料提供新的思路。同时,浸润性从超疏水到亲水转变过程中,表面从低粘滞状态变为粘滞状态。这一过程为实现光电协同控制的图案化浸润提供了可能性,即在低于电浸润阈值电压的条件下,通过图案化的光照来实现液体图案化浸润。

The charts of velocity vector of flow field outside the tube under five conditions with amplitude 1.3 mm and frequency 5—25 Hz were obtained,and the cosine of average synergy angle of flow field outside the tube was calculated.

实验及模拟结果表明:振动能够显著增加管外近壁区的流体速度,能够在振动方向上的管壁两侧形成有效的冲刷,随着振动频率的升高其管外近壁区的平均速度近似呈线性增加,在共振点出现峰值;相同区域内振动工况的平均场协同角余弦值要明显大于无振动工况,但不同振动频率间的场协同角余弦值变化较小。

We also showed that coadministration of AG825 or AG1478 will enhance the efficacy of cytotoxic AGent cisplatin.

了解5种人类非小细胞肺癌细胞系A549、H322、H358、H460、H1299的HER2和EGFR蛋白表达水平,探讨5种细胞系HER2蛋白表达水平与顺铂IC50之间的关系;观察HER2和EGFR小分子酪氨酸激酶抑制剂AG825和AG1478对5种细胞系的生长抑制作用;观察AG825、AG1478联合顺铂对5种细胞系的协同生长抑制作用;研究AG825、AG1478联合顺铂对H322、H1299细胞系细胞增殖、细胞周期、细胞凋亡和坏死的影响;研究AG825、AG1478联合顺铂所致H322、H1299细胞系EGFR、磷酸化ERK和总ERK表达的变化,探讨协同生长抑制作用的机制。

The "role of the teacher" in this study is not an authority who is interested in pursuit of impersonal nomothetic knowledge.

在这个置於社会场境的教育历程中,教学者视为一个文本诠释的积极参与者与叙说协同规划者,而非权威的知识传授者;如此协同所追求的并非客观定律式的知识,而是生命经验的美感与感知,其具有生命情意教育、弱势发声与社会实践的积极意义。

This paper analyzed the mechanism of concurrent operation conflict in collaborative CAD system.It presented the general expressing method of operation order,put forward the versatile distinguishing inferential method based on this description,and this method is applied to the analysis of concurrent operation conflict in 2D graphics system and 3D feature modeling system of products based on field knowledge.The results oftest show that this method is feasible with a high collaborative efficiency.

分析了协同CAD系统的并发操作冲突的机理,给出了操作命令的一般表示方法,提出一个通用的基于该描述的冲突判别推理方法,并基于领域知识将该方法用于二维绘图系统和三维产品特征建模系统中的并发操作冲突的分析,实验结果表明该方法可行,协同效率高。

The results showed that the POV of hemp seed oil was affected remarkably by temperature and time, and the effect of temperature was greater than that of time. The TBHQ had good antioxidation ability to hemp seed oil. TBHQ or BHA with isoascorbic acid or critic acid exhibited great antioxidation ability, the synergistic effect on the oil of critic acid was better than that of isoascorbic acid. When 0.02% TBHQ with 0.005% BHA and 0.01% critic acid or with 0.005%BHA and 0.01% isoascorbic acid was used in the oil, the shelf life of the oil could be prolonged from 4 months to 11~13 months at 20℃.

结果表明,温度、时间对汉麻籽油的自氧化过程有显著影响,且温度的影响更明显;叔丁基对苯二酚对汉麻籽油具有较好的抗氧化性能,柠檬酸和异Vc对TBHQ与丁基羟基茴香醚复配的复合抗氧化剂均表现出较强的协同抗氧化性能,且柠檬酸的协同抗氧化性优于异Vc;添加0.02%TBHQ+0.005%BHA+0.01%柠檬酸或0.02%TBHQ+0.005%BHA+0.01%异Vc复合抗氧化剂,可使汉麻籽油在20℃下的预贮藏时间从4个月延长至11~13个月。

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This one mode pays close attention to network credence foundation of the businessman very much.

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