半致死的

In the present study, the acute and sub-acute toxicity of copper on amphioxus and rosy barbs was investigated.

采用半静水实验法测试研究了重金属Cu(上标 2+)对文昌鱼和玫瑰无须鲃的急性致死毒性和亚急性毒性。

The results indicated that the treatment of irradiation restrained the growth and differentiation of protocorm, especially to roots.The LD50 is 67.23Gy, because the protocorm is a integrate embryoids and higher tolerance was found. Ploidy analysis showed that most of aberrant seedlings go with the change of DNA and they were not euploid. When the plants trearted by irradiation, some of aberrant seedlings appeared stem forfication, and leaves appeared chlorophyll-deficient or green-white.,probably due to some genes' expression or closing.

结果表明：辐照处理对种胚原球茎的生长和分化有抑制作用，尤其是对根的抑制更为明显；由于种胚原球茎的完整性好，耐受性强，其辐照半致死剂量(LD50)为67.23Gy；流式细胞分析表明，大多数外部形态发生改变的植株其细胞内DNA的倍性发生了改变，出现相当多的非整倍体；此外，辐照产生的变异苗出现茎分叉、叶片缺绿或白绿相间等现象，可能是由于某些基因的表达与关闭引起的。

The sry-gene chimerism of bone marrows, spleen and thymus of the receiptor, T-lymphocyte subpopulation of peripheral blood cells, ConA and LPS induced T and B cells proliferation activity tests, Mixed lymphocyte reaction between the donor and the receiptor and the third part, the incidence rate of GVHD and survival analysis were observed in mice after 8Gy TBI with MSCs and haplo-BMT treatment together.

通过观察半相合BMT联合MSCs治疗致死剂量照射小鼠后不同时间骨髓、胸腺和脾脏中供者细胞植入，外周血中的淋巴细胞亚群，ConA和LPS刺激的T、B淋巴细胞增殖，供受者及第三者混合淋巴细胞反应，急、慢性GVHD的发生率和生存分析，提示MSCs促进骨髓干细胞植入，加快T淋巴细胞增殖，促进体液免疫恢复，通过供受者免疫耐受，减少GVHD发生率，提高半相合BMT动物生存率。

Objective The present work is designed to quantify the relationship between the sublethal damage repair modify factor and the half-repair time (T1/2) as well as fraction interval.

目的 研究细胞在不同半修复时间（T1/2）和照射间隔时间条件下，由于亚致死性损伤修复所需在线性二次模型中引入的修正因子的变化趋势。

In the acute toxicity experiments, the 96h-LC50 were 1.0×105 cells·mL-1 for the intact algal solution and 8.0×104 cells·mL-1 for the lysate. In a 7 day subacute experiment on the larvae, higher concentrations of algal solution inhibited S. macrocephalus larvae. The toxicity of the algal solution was higher than that of the lysate at the same concentration.

在仔鱼96h的急性毒性实验中，微小亚历山大藻对仔鱼的96h理论半致死浓度分别为1.0×105 cell·mL-1、8.0×104 cell·mL-1，而在7d的亚急性实验中，高浓度藻细胞液对仔鱼的生长发育有一定的抑制作用，且相同浓度下，藻细胞液产生的毒性较藻细胞破碎液大。

In the acute toxicity experiments, the algal solution and breakup solution of the concentration of 96h-LC50 were 1.0×105cells/mL and 8.0×104cells/mL, respectively. In the subacute 7 days experiment of the larvae, higher of the algal solution has the inhibition effect on sparus macrocephalus larvae. The toxicity of algal solution was higher than that of breakup solution at the same concentration.

在仔鱼96h的急性毒性实验中，微小亚历山大藻对仔鱼的96h理论半致死密度分别为1.0105 cell·mL-1、8.0104 cell·mL-1，而在7d的亚急性实验中，高浓度藻细胞液对仔鱼的生长发育有一定的抑制作用，且相同浓度下，藻细胞液产生的毒性较藻细胞破碎液大。

Expression analysis with RT-PCR revealed that PcLGBP gene was exclusively expressed in hepatopancreas and the expression could be up-regulated by heat-killed Listonella anguillarum. The binding specificity of PcLGBP to ligand were subsequently examined by recombinant expression of the cDNA fragment encoding its mature peptide in Escherichia coli BL21 (DE3) and ELISA approach.

为分析PcLGBP基因的功能，通过半定量RT-PCR方法研究了其在组织中的分布，并用荧光定量PCR技术分析了其对细菌刺激的响应，结果表明PcLGBP基因是肝胰腺特异表达的基因，能响应热致死鳗弧菌刺激而增强表达，说明PcLGBP基因可能参与螯虾的细菌防御反应。

Results showed that there were significantly positive linear correlations between the toxic effects（probits of mortality and inhibition rate） of chlorpromazine on the two aquatic organisms and the concentrations of chlorpromazine, and the toxic intensity became higher as the exposure time increased. The LC50 values of chlorpromazine acting on Carassius auratus in 24, 48 and 96h were 1.11, 0.43 and 0.32mg·L-1, respectively; and its safe concentration for Carassius auratus was 19.5μg·L-1. The LC50 and EC50 （50% of the tested Daphnia magna inhibited） values of chlorpromazine acting on Daphnia magna in 24h were 0.65 and 0.57mg·L-1, and the LC50 and EC50 values in 48h were 0.36 and 0.28mg·L-1, respectively. Thus, chlorpromazine have high toxicity to Carassius auratus and Daphnia magna, and the latter is more sensitive to chlorpromazine.

结果表明：氯丙嗪对两种水生生物的毒性效应（致死率、抑制率概率单位）均与其浓度呈显著线性正相关关系（p.05），且毒性强度随作用时间的延长而增加；氯丙嗪对鲫鱼的24、48和96h的半致死浓度（LC50）值分别为1.11、0.43和0.32mg·L-1，通过计算求得氯丙嗪对鲫鱼的安全浓度为19.5μg·L-1；氯丙嗪对大型蚤的24h LC50值为0.65mg·L-1，24h EC50值（使50%受试大型蚤活动受抑浓度）为0.57mg·L-1；48h LC50值为0.36mg·L-1， 48h EC50值为0.28mg·L-1；对鲫鱼和大型蚤而言，氯丙嗪属极高毒性物质，大型蚤对氯丙嗪的敏感性大于鲫鱼。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

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如果有任何问题，你可以随时联系我。