半抗原的

The observed results provide a plausible mechanism for how haptenization of self-antigens can lead to the development of autoimmunity.

上述观察结果为阐明自体抗原的半抗原化为何会引起自身免疫性疾病提供了一种似乎合理的解释。

Objective To study the preparation and characterization of hapten and artificial antigen of dicyclohexyl phthalate.

目的合成邻苯二甲酸二环己酯半抗原衍生物和合格的人工全抗原，探讨其制备方法。

In this paper,the design of hapten synthesis,the synthesis of hapten-protein conjugation,the pre-treatment of sample as well as the application of the immunoassay in residues detection of insecticides,fungicides,herbicides,and growth regulators,were introduced and...

本文简要介绍了农药残留免疫分析方法建立中半抗原合成设计、人工免疫抗原合成、样品前处理等技术的关键环节和免疫分析技术在杀虫剂、杀菌剂、除草剂和生长调节剂等农药残留快速监测中的应用进展，并对农药残留免疫分析技术存在的问题和应用前景进行了讨论。

The synthesized hapten of triazophos was covalently conjugated to bovine serum albumin and ovalbumin respectively to prepare artificial antigen and coating antigen.

将合成的三唑磷半抗原采用活性酯法分别与牛血清白蛋白和卵清蛋白共价偶联制备突出三唑磷分子结构特征的人工抗原与包被抗原。

Using progesterone and bovine serum albumin as model compounds respectively, fluorescent labeled small molecule hapten and large molecule antigen were prepared.

1以孕酮和牛血清白蛋白为模型化合物，制备了小分子半抗原和大分子抗原的荧光标记物，研究了标记物的抗原活性和光谱性质，结果表明标记物是有效的毛细管电泳免疫分析试剂；制备了抗体F〓片段，研究了其抗体活性，结果表明F〓片段比整个抗体更适合作为毛细管电泳的免疫分析试剂。

The application of molecular modeling in immunogen and competitor design was emphasized. The advantage of the application of molecular modeling was revealed.

重点阐述了分子模拟在免疫原和竞争原设计中的应用，揭示了采用分子模拟技术进行半抗原设计的优势在于其能够克服目前半抗原设计方法的经验性和主观随意性。

In the method, the polyclonal antibodies are obtained by utilizing syntactic quinoxalone antibiotics multi-cluster antigen immunization; the coupling compound of the half antigen of the quinoxalone antibiotics and an egg-white protein OVA is taken as an envelope antigen; the quinoxalone antibiotics is taken as a standard; the indirect competitive enzyme-linked immune detection method for the quinoxalone antibiotics in animal food is established; a rapid and high efficient detection means is provided for the residues of the quinoxalone antibiotics in the animal food; because the polyclonal antibodies are adopted, the cost is low, and the stability and the repeatability are good; the detection limit (IC is smaller than 90) is 0.0126 ng/ml, the median inhibitory dose (IC is smaller than 50) is 0.52 ng/ml, and the detection range (IC is smaller than 20 to 80) is 0.04467 to 14 ng/ml.

本发明利用合成的喹诺酮类抗生素多簇抗原免疫得到多克隆抗体，以喹诺酮类抗生素半抗原与卵清蛋白OVA的偶联物作为包被抗原，以喹诺酮类抗生素为标准品，建立动物性食品中的喹诺酮类抗生素的间接竞争酶联免疫检测方法；为喹诺酮类抗生素在动物性食品中的残留检测提供了快速高效的检测手段，由于采用的是多克隆抗体，费用较低并且稳定性和重复性较好，检测限(IC 90 )为0.0126ng/ml、半数抑制量(IC 50 )为0.54ng/ml和检测范围(IC 20 ～IC 80 )为0.04467～14ng/ml。

Also, antigens of different size utilize these regions differently; while haptens mainly interact with the central core, larger antigens have additional interactions in more peripheral regions.

同样，大小不同的抗原对这些区域的使用也有不同之处：半抗原主要与中央核结合，大抗原则与更多的外围区域有额外的相互作用。

Since haptens do not occupy the entire available paratope we hypothesized that hapten-specific antibodies, as they develop naturally or in the laboratory, have an imprint of the carrier protein they were once selected on.

由于半抗原并没有占据所有可利用的表位，因而我们设想，特异的半抗原抗体在天然形成或在实验室合成时，肯定具有一些曾经被用来对其进行筛选的载体蛋白的某些特征。

On the basis of the initial mechanism of deiodinase and the idea of hapten design derived from the method of"hydrophobic pocket modification", three haptens of thyroxine derivatives, o-methyl-〓, o-benzyl-〓 and o-p-nitro-benzyl-〓 with successively-raising hydrophobicity, were designed and synthesized, and their structures characterized.

以天然脱碘酶的初步催化机制和疏水腔修饰法的半抗原设计思想为依据，设计合成了三种疏水性不同的甲状腺素衍生物半抗原：o-methyl-〓，o-benzyl-〓和o-p-nitro-benzyl-〓，并对其结构进行了表征。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失