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Results: The renal perfusion was increased in diabetes group after the injection of alloxan. The PSI, AUC and ascending slope rate of the curve of the time-intensity curve were increased in 1w and 2w with decreased of HPT; the pathological examination exhibited glomeruli hypertrophy and no thickening of basal lamina. The PSI and AUC in 4w and 6w were more than that of control group; the PIT and ascending slope rate of the curve got closed to normal in 4w and 6w; the intercapillary cells increased. The speed of ascending slope rate of the curve in 8w, 10w and 12w was slower, shown as PIT and HPT delayed; the pathological examination showned increasing of mesangial cell, hyperplasia of mesangial matrix and thickening of basal lamina, followed with obliteration of partial micrangium, glomerular sclerosis and reduce of PSI in 12w.

结果:糖尿病组兔注射四氧嘧啶后肾皮质血流灌注增大,1周、2周表现为时间-强度曲线参数中峰值强度升高、曲线下面积增大、达峰时间缩短、曲线上升斜率升高,此时病理可见肾小球肥大,系膜基质正常,基底膜无增厚;4周、6周,峰值强度、曲线下面积高于对照组,达峰时间、曲线上升斜率接近正常,系膜细胞增多。8周、10周、12周,达峰时间延长、曲线上升斜率减慢、峰值强度减半时间延长,病理出现肾小球系膜细胞明显增多,系膜基质增生,基底膜增厚,至12周病理出现部分毛细血管管腔闭塞,肾小球节段性硬化,峰值强度测值减低。

Results showed that DCF with different dosages could increase the frequency of micronucleated erythrocytes markedly,except the first injection of the dosage with 5 and 10 mg/kg,every group caused an increase in the frequency of nuclear abnormality erythrocytes,the effects in cell membrane and cytoplasm were less than the effects in karyon by DCF,and the most toxicity was exhibited after the second injection.

结果表明,注射DCF后所有剂量组均能引起中华蟾蜍红细胞微核细胞率显著升高;除5,10mg/kg剂量组在第1次注射后较对照组低外,其他注射剂量和次数均引起核异常细胞率升高,DCF对细胞膜与细胞质的影响小于其对细胞核的影响,在4次注射中以第2次注射后对红细胞的毒性效应最大。

Chronic experiments were performed on male rabbits provided with implanted brain cannula,through which acetylcholine was injected into the hypotha- lamus and the third ventricle.

二将乙酰胆硷0.7—1.4毫克注入下丘脑结节区,可引起血浆自由脂肪酸水平明显升高,在注射后的第10及20分钟分别较注射前升高78.5%及85.0%,60分钟时恢复原水平。

As for the monitor of water pollution, Lemna minor, Spirodela polyrrhiza shleid and Azalla imbricate Nakai could be used as the monitors for the naphthalene pollution in water body because of their sensitivity to it.

在净化过程中,萘对5种水生植物产生生理毒害作用,且随萘浓度的增加显示出明显的毒害效应,表现为呼吸强度受到抑制,叶绿素含量降低;对POD而言,凤眼莲、喜旱莲子草随萘浓度增加逐渐升高,而浮萍、紫萍则表现出先升高然后降低,满江红一直降低。

In germination experiment, illumination had no effect on germination rate. Within certain range, rising temperature may accelerate germination rate of Lepidium apetalum, but had no effect on other species. The vermiculite of different soils also has great effect on seed germination.

萌发实验结果则表明,光照对四种短命植物种子萌发率没有显著影响;在一定范围内温度的升高能够促进独行菜种子的萌发,而温度升高对其它三种短命植物没有显著影响。

Results Leucocytopenia and lymphocytopenia were seen in all the patients. Two patients had slightly decreased peripheral blood T lymphocyte count. Alanine aminotransferase and aspartate transaminase levels increased slightly in 3 patients. No hypoxemia was seen in all the patients. Both SARSIgM and IgG seroconversion occurred earlier in all the patients with the titer increased more than 4fold shortly. Neutralization test was positive in all the patients. SARS coronary virus RNA was detected by polymerase chain reaction in pharyageal swabs only in 1 patient.

结果 确诊的SARS患者白细胞及淋巴细胞呈不同程度降低,下降时间较流行时提前,下降程度较小;2例外周血T细胞亚群计数轻微降低;3例丙氨酸转氨酶和天冬氨酸转氨酶轻度升高;肾功能、血糖、血脂及心肌酶均无异常;所有患者血清SARSIgM/IgG抗体早在发病第6 d由阴转阳,滴度在短期内呈4倍以上升高,中和抗体实验阳性,1例咽拭子中检测出SARS冠状病毒RNA。

In vitro culture studies of childhood myelodysplastic syndrome: establishment of the cell line MUTZ-1. Leuk Lymphoma, 1997;

大量实验表明,很多细胞在凋亡早期会出现胞质内Ca2+浓度迅速持续的升高,这种浓度升高来源于细胞外Ca2+的内流和胞内钙库的释放。

Supplement of pyruvate can increase serum LPL levels remarkably(p.05)and decrease serum HL level but no significant statistical difference in rats and swimming rats, decrease serum T4 levels during resting obviously(p.05)in rats and reduce serum T4 levels to certain extent in swimming rats. It indicated that pyruvate supplement could regulate lipometabolism in rats and swimming rats by means of the effect on enzyme and hormone levels.

丙酮酸补充还可明显降低大鼠血糖水平(P.05),一定程度地升高其血清FFA水平;明显降低大鼠血清TC水平和游泳大鼠血清TG水平(p.05),使大鼠和游泳大鼠血清HDL-C含量呈一定的升高趋势,并明显降低了游泳大鼠血清LDL-C水平(P.05),这表明丙酮酸具有持久、稳定的降血脂作用,配合运动补充,作用效果可能会更明显;4。

Results: The expression of HO-1 mRNA in macrophage cell was significantly enhanced by the melilotus suaveolens extract. The result of Western blot showed that the expression of HO-1 protein was significantly increased after the intervention of melilotus suaveolens extract.

结果:臭苜蓿根提取物明显升高巨噬细胞HO-1的mRNA表达水平,Western blot结果显示,臭苜蓿根提取物干预后HO-1的蛋白表达水平也明显升高

2Myocardial ultrastructure was normal in the control group,myoneme arranged disordered,the structure of typical sarcomere disappeared, mitochondrium intumesced,interstitial substance fiber hyperplasy,capillary vessel endothelial cell swelled in DG group.Myocardial ultrastructure improved slightly in rats of SM and LM groups. 3NF-κB p65 and COX-2 had a small quantity to present in the myocardium tissue of control group,while the quantity increased obviously in the diabetic group.The level of it in the group of treatment was significant lower than that in the diabetic group.There was significant difference between the two groups. Conclusion Metformin can protect against the heart injury in diabetic.

结果 1与对照组比较,DG组体重明显减轻,血糖、心脏质量指数、INS、TG、T-CH及FFA明显升高(P<0.01);应用 MT治疗后体重无明显增加,INS有所下降,心脏质量指数、血糖、TG及FFA明显降低(P<0.01);DG组心肌组织MDA明显升高,SOD明显降低(P<0.01),MT治疗后上述指标明显改善;2超微结构观察单纯糖尿病组肌丝结构明显紊乱,典型肌小节结构消失,线粒体肿胀、间质纤维增生,微血管内皮细胞肿胀等表现,而SM及LM组可见组织结构有所改善;3对照组心肌NF-κB p65及COX-2只有少量表达,单纯糖尿病组表达量明显增多(P<0.01),MT治疗后表达量明显减少(P<0.01)。

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The split between the two groups can hardly be papered over.

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