化学生物学

Of the late two years,in order to find out a kind of dental implant ing materialwhich would possess both the very good properties of biological compatibility,the chemical compatibility and the mechanical compatibility,an animal experi-mental preselection was accomplished by our research team with six kinds of im-planting material chosen from four main sorts of oral implant ing material(met-al,ceramic,high polymer and carbon),As the result of the Preselection,thematerial……bio-ceramic was chosen by ...

为了寻求生物相容性、化学相容性和力学相容性均好的种植材料，在口腔四大类种植材料(金属、陶瓷、碳素、高分子)中，选用6种材料作了动物实验预选。根据预选结果，选定以生物陶瓷为主攻方向，从而研制成功锆磷灰石陶瓷，以之进行了理化性能、生物学性能、及动物实验考查，合平种植要求。并以考查结果与钛合金、多晶氧化铝、单晶氧化铝、钛合金喷涂氧化铝、低温各向同性碳、聚砜种植作了比较，主要性能均较其它几种比较材料为优。经临床初试，锆磷灰石陶瓷的种植效果也较好，其界面为骨性结合。

It well informs the research advances in all aspects of acarus and their control, including veterinary medicine, ecology, epidemiology, physiology, biochemistry, toxicology and pesticide resistance, immunology, genetics and molecular biology etc.

该杂志全面提供了螨虫以及对其控制的各方面研究进展，内容涉及兽医学、生态学、流行病学、生理学、生物化学、毒物学与杀虫剂抗性、免疫学、遗传学以及分子生物学等等。

"Natural science research\",\"自然科学研究\",\Includes mathematics, physics, chemistry, biology, agronomics, medicine, geology and astronomy research activities.

"，\"包括数学，物理，化学，生物学，农学，医学，地学，天文学等自然科学的研究活动\

Course of Antecedence: Biochemistry, cell bilogy,Genetics and basic knowledge of computer.

先修课程：生物化学、细胞生物学，遗传学、应用计算机基础

Its areas of current emphasis are: Computer-Aided Drug Design, Macromolecular Modeling, Pharmacology, Neuroscience, Astrochemistry and Astrobiology.

目前，它的科研重点是计算机辅助的药物设计，大分子建模，药理学，神经科学，天体化学和太空生物学。

The research interests in the centre for astrophysics and planetary science include solar system studies, astrobiology, space missions, star formation, astrochemistry, superconducting astronomical detector development, and the cosmic history of galaxy formation.

该中心研究的兴趣在天体物理学和行星科学，包括太阳系的研究，太空生物学，太空任务，恒星的形成，天体化学，超导天文探测器的研究的发展，以及银河形成的宇宙历史。

The journal publishes papers embracing all aspects of histochemistry and microtechnic in all areas of the biological sciences from botany to cell biology to medicine, including in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, image analysis, cytogenetics and automation or computerization of investigative procedures.

杂志刊载了内容涉及生物科学中从植物学到细胞生物学到医学所有方向的组织化学和显微技术所有领域的论文，包括原位杂交，细胞化学探针，放？？？？？？？自显影，光和电子显微镜，组织培养，图象分析，细胞遗传学和自动或计算机研究方法。

The study of the biological characteristics of resistant phytopathogenic fungi has great theoretic and practical significance for improving the strategy of chemical pesticide application, postponing the occurrence of the resistance and advancing the chemical prevention and control of diseases caused by phytopathogenic fungi.

研究植物病原真菌抗药菌的生物学特征以及它们的抗药机制对于改进化学农药使用策略，延缓抗药性的产生，推进植物病害的化学防治，具有十分重要的理论和实践意义。

①Rat MSC and VSMC were cultured and identified, respectively. MSC were labeled with DAPI firstly, and then co-cultivated with VSMC. The changes of morphology and ultrastructure of co-cultured cells were observed. Immunfluorescence analysis was performed by using monoclonal antibodies against specific antigen.②We established the regulatable system in two steps: a stable MSC line expressing rtTA has been constructed and characterized firstly by transfected with pUHD 17-1hyg and then selected by hygromycin B; in a second step, this line was used for trandfer the AT2R gene to MSC to get the well establishing double stable MSC lines;③The expression of AT2R regulated by doxycycline was evaluated by western blot;④The MSCs were transduced into rat carotid arteries with regulatable AT2R gene after the establishment of rat carotid balloon injury restenosis model. The intimal/medial area ratio were measured by digital analysis system.

研究方法：(1)密度梯度离心法及胶原酶消化法分别培养原代大鼠MSC及VSMC，细胞共培养并行免疫荧光化学染色和透射电镜观察超微结构；(2)组成受Dox调控的哺乳动物表达系统的四种成分的转化、扩增及提纯并酶切鉴定；(3)采用常规分子生物学方法连续两个回合转染体外培养的MSC，并分别采用发光计检测不同细胞克隆萤光素酶活性改变以及RT-PCR方法检测AT2R目的基因mRNA表达情况，根据各个细胞克隆受Dox调控表达的程度，选择低背景、高诱导表达AT2R的细胞系，作为双重稳定MSC细胞系；蛋白免疫印迹法观察该细胞系在Dox调控下AT2R表达的时相性、持续性及在不同浓度Dox调控下的表达情况；(4)建立大鼠颈动脉球囊损伤动物模型，将双重稳定MSC在术中导入血管，分别于14 d、28 d进行病理切片，检测可调控AT2R对新生内膜增生的影响；采用RT-PCR免疫组织化学免疫荧光等技术观察AT2R基因在新生内膜中的表达以及细胞外基质成分表达的改变，TUNEL法检测血管组织中细胞凋亡的变化情况。

The system of nano-structured assembly and molecular assembly is a new field, which is originated from intercrossing and derivatives of physics, chemistry, biology and material science in nanometer scale. It has not only brought the new opportunity to synthesis of new materials, but also opened the new dimension for physical and chemical investigation. The most importance is that it will be the basis of nano-structured device in the future.

纳米结构的组装和分子组装体系是物理、化学、生物学、材料科学在纳米尺度交叉而衍生出来的新的学科领域，它为新材料的合成带来新的机遇，也为物理和化学的研究提供了新的方向，更为重要的是它将成为下一代纳米结构器件的基础。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。