化学生物学

Based on the development of natural biopharmaceuticals and nutriceuticals, the advances in research and development of the resource plant Phyllanthus emblica L., widely distributed in many provinces of South China, are summarized, including its biological, phytogeographical, traditional herbal medicinal, pharmacological and phytochemical studies.

从开发天然功能保健食品的角度，总结了分布于我国南方各省的资源植物余甘子(滇橄榄，Phyllanthus emblica)的生物学、植物地理学、传统草药学、药理学、植物化学等的研究与开发进展，包括作者实验室近年开展的有关余甘子果汁澄清和果酒&去沉淀&的微生物酶法加工技术部分内容，以及引人关注的余甘子果植物多酚提取物及其在美白护肤品新用途的开发，讨论了金沙江干热河谷地域余甘子农业栽培的可行性。

Tissue engineering is a multidisciplinary science merging with cell biology, material science, engineering and chemistry. Its basic idea is to expand a number of cells in vitro and seed them on a polysynthetic biodegradable polymer structure, and finally enable the organization of 3-dimmentional and functional tissues or organs.

组织工程技术是融合了细胞生物学、材料科学、工程学和化学的一门边缘学科，它的基本思想是用少量组织细胞经体外培养扩增后播种在可降解的生物支架材料上，再回植入体内形成有功能的组织或器官。

Orange-spotted grouper is a benthic protogynous marine fish with sex inversion. It is one of the most important culturing fish in the southeast of Asia. As in other vertebrates, its growth is mainly controlled by growth hormone . Few data are available concerning the regulation of GH in grouper. In this paper, the regulation of growth hormone release from pituitary of orange-spotted grouper and its mRNA level was determined by radioimmunoassay and RNase protection assay.

中文题名斜带石斑鱼生长激素分泌及其基因表达调控的研究副题名外文题名 Regulation of growth hormone and its gene expression in orange-spotted grouper，Epinephelus coioides 论文作者冉雪琴导师林浩然学科专业水生生物学研究领域\研究方向学位级别博士学位授予单位中山大学学位授予日期2003 论文页码总数140页关键词生长激素基因表达石斑鱼馆藏号BSLW /2003 /Q959 /39 应用分子克隆技术，构建了斜带石斑鱼生长激素(Growth hormone，GH)基因重组质粒，在大肠杆菌细胞中获得高效表达，亲和层析纯化斜带石斑鱼GH融合蛋白做为抗原，免疫家兔制备特异性抗体，通过酶联免疫实验、放射免疫测定、离体脑垂体静态孵育和液相杂交／核糖核酸酶保护试验及化学发光检测技术，研究了斜带石斑鱼GH分泌及其mRNA表达的调控机制，对于斜带石斑鱼的生长、繁殖、人工养殖等具有重要意义。

This paper reviews the biological characteristics,chemical composition and anticancer mechanism,propagation techniques and the situation of the resources conservation and utilization of Pteris semipinnata L.

综述了半边旗的生物学性状、化学成分及抗癌机理、繁殖技术和资源保护利用现状，并对当前研究中存在的问题提出了相应的建议，同时对半边旗的发展前景进行了展望。

And whereas species were originally defined in terms of morphological traits, today biologists generally use the criterion of a reproductively

来自于生物化学和比较解剖学等亚生物学领域的证据有助于划分物种和更高级的分类单位，然而物种最初依据形态学特征进行分类的，今天生物学家大体上使用孤立多产的群体作为标准。

To identify cytoskeletal proteins that change conformation or assembly within stressed cells, in situ labeling of sterically shielded cysteines with fluorophores was analyzed by fluorescence imaging, quantitative mass spectrometry, and sequential two-dye labeling.

从蛋白质的氨基酸序列来预测它的三维结构是计算生物学和计算化学长期面临的挑战。研究人员40多年前就知道蛋白质的结构完全是由其氨基酸序列决定的，但是用序列信息来做结构的预测极为困难。

During the last few years a large amount of evidence has provided new insights into the biochemistry and molecular biology of cartilage, subchondral bone, and other articular tissues, which suggest distinct etiopathogenetic mechanisms in some forms of primary OA.

过去几年中的大量的证据，让我们在软骨，软骨下骨及其他关节组织的生物化学和分子生物学方面获得了新的认识，提示某些类型的原发性关节炎有不同的发病机制。

The functions of the secretory barrier of the tracheobronchial tree are physical, chemical, immunological, and biological.

气管支气管树分泌屏障的功能有物理的、化学的、免疫学的和生物学的。

objectiveto observe the biological characteristics of trametes lactinea berk.

目的观察大白栓菌的生物学特征，检识其化学成分。

Ras homolog enriched in brain, a small GTPase, positively regulates the mTORC1 pathway. The GDP-GTP exchange of Rheb has been suggested to be facilitated by translationally controlled tumor protein. Here we demonstrate that human TCTP interacts with human Rheb and accelerates its GDP release in vitro, and that hTCTP activates the mTORC1 pathway in vivo.

丁建平研究组运用体外 GST-pulldown 和鸟嘌呤交换等生物化学实验以及对 TCTP 降低表达和过量表达等细胞生物学实验，证明了人源 TCTP 具有针对 Rheb 的弱 GEF 活性，能正向调控 mTOR 信号通路。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。