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化学合成

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Objective: through various chemical synthesis target compounds 4 -- 6 - the - 7 -(2 - hydroxyl replace c oxygen radicals) quinazoline compounds were synthesized and the structure of the modified, so as to get high epidermal growth factor receptor tyrosine kinase inhibitor.

目的:通过各种化学合成方法完成目标化合物4--6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉的合成并对目标化合物进行结构修饰,以期获得高活性的表皮生长因子受体酪氨酸激酶抑制剂。

The strategy of building the syn-anti chiral vicinal diolmoiety of sphingosine intermediate and the synthetic studies of anti-fungal antibioticssphingofungin using sugar as chiral pool are also described.

这些物质生理作用极强,但在机体中储存量极少、结构具有高度不均一性、生物和化学稳定性又差,它们的化学合成具有十分重要的理论和应用意义。

Lots of new production technologies to enhance the competitive power of products have worked out in China's companies such as technologies for producing vitamin C manufactured via two-step zymosis; synthesizing chemically vitamin E with the domestically produced key intermediates linalool, isophytol and trimethylphenol; preparing vitamin B2 gained by genetically engineered bacterium fermentation, and commercialized production of vitamin H, etc.

我国企业研究出许多维生素生产新工艺,提高了产品的竞争力,开发的新工艺有两步发酵法生产维生素C,化学合成维生素E的关键中间体芳樟醇、异植物醇和三甲基苯酚等原料国产化,基因工程菌发酵生产维生素B2,维生素H的工业合成等。

The experiments on the chemical synthesis of DL-phenylalanine employed the Modified Aniline way, the Diazo Reaction, Hydrolysis Reaction, and Aminate Reaction in turm to synthesize the DL-phenylalanine.

混旋苯丙氨酸化学合成实验部分首先采用改进苯胺法,经重氮化反应、Meerwein反应、水解反应、氨化反应,合成混旋苯丙氨酸,收率达到84%。

The progress on chemical synthesis and biosynthesis of levulinic acid and 5-aminolevulinic acid(5-ALA) were discussed.

基于生物质资源的利用和开发,论述了乙酰丙酸的制取、5-氨基乙酰丙酸的化学合成与生物合成,阐述了其在医药、农业等方面的应用,讨论了发展趋势和亟待解决的问题。

To elucidate the structural features and the antimicrobial activity of this fragment, we re-designed and synthesized two peptides corresponding to the main mimic structures of Mytilin-1 from Mytilus coruscus, we named these two peptides Mytilin Derived Peptide-1 and Mytilin Derived Peptide-2, respectively.

为验证该区域是否具有抗菌活性,通过对厚壳贻贝Mytilus coruscus抗菌肽Mytilin进行空间结构模拟,选取其中β-发夹部分肽段,采用了固相化学合成的方法合成了两条10肽,分别命名为Mytilin Derived Peptide-1 (MDP-1)和 Mytilin Derived Peptide-2 (MDP-2)。

Five synthesis methods of AlN powder were discussed,namely direct nitrogenation of Al powder,carbothermal reduction of Al2O3,chemical vapor deposition,sol-gel method,self-propagating high-temperature synthesis and plasma chemical synthesis.

凝胶法、自蔓延高温合成法和等离子化学合成法;分析AlN烧结助剂的选择和5种烧结工艺:热压烧结、无压烧结、放电等离子烧结、微波烧结及自蔓延烧结;阐述AlN基板的制备工艺及其影响因素。

Recombinatino polypeptide or chemically synthesized polypeptide antigen is used to immunize the mammal to obtain polyclonal antibody and the nonconservative amion acid sequence of the antiboby to N-terminal with recognition site qBrn-2 of development regulatory protein qBrn-2. The antibody does not recognize other POU structure domain protein, and recognizes specifically qunique protein in Western imprinting experiment. The qBrn-2 expression mode obtained immunohistochemistry process is identical with the resulted height of in-situ molecular hydridization.

以重组多肽或化学合成多肽为抗原免疫哺乳动物获得的多克隆抗体,这一抗体对发育调控蛋白qBrn-2的识别位点为qBrn-2的N-末端的非保守性的氨基酸序列,该抗体不识别其它POU结构域蛋白;在Western印记实验中,该抗体特异地识别单一的蛋白;利用免疫组织化学接示的qBrn-2表达模式与分子原位杂交的结果高度一致。

Synthesis and characterization of Polyaniline nanoparticles in the presence of magnetic field and Samarium ChlorideInteractions of PANI with metal ions give rise to novel chemical and physical properties of the formed macromolecular complex.

一、在磁场和SmCl_3存在下化学合成聚苯胺纳米粒子聚苯胺和金属离子作用形成的大分子配合物具有新颖的化学和物理性质。

The cDNA squence of antibiotic, an antibacterial peptide, a process for preparing the said cDNA and a process for recombining the antibacterial peptide are disclosed. The present frequency of amino acid codens in Attacin A cDNA is analyzed. The high-frequency coden is introdued to its protein sequence to configure its cDNA sequence. The target gene is synthesized by chemical synthesis method or polymerase chain reaction.

本发明公开了葛佬素的cDNA序列,葛佬素cDNA的制备方法以及重组抗菌肽葛佬素的制备方法;通过对同种已知蛋白质Attacin A cDNA中氨基酸密码子的出现频度进行分析,采用出现频度高的密码子带入葛佬素蛋白质序列中进行葛佬素的cDNA序列构建,用化学合成法及聚合酶链式反应进行目的基因的合成,另外,采用基因重组法制备抗菌肽葛佬素,并测定了其活性。

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