化合物

Initial experiment showed that the aromatic compounds were brominated to corresponding bromides with hydrobromic acid or bromine as brominating agent in the presence of sodium nitrite under the mild conditions.

研究发现在NaNO_2存在时，氧气能够以HBr(或Br_2)为溴化试剂，在温和条件下将芳香化合物氧化溴化生成相应的溴代芳香化合物。

These conditions included original material source, reagent ratio, base solutions, power of the microwave, reaction time and so on.2, Chitosan obtained from above was modified by Schiff base type macrocycles, which was prepared by the reaction of the reagents of salicylaldehyde, glacial acetic acid, hydrobromic acid, chloroepoxy propane and the others.

反应的最优化条件为：物料比1：25；反应时间20min；NaOH溶液浓度为50%；微波功率为450w。 2、利用原料水杨醛、氢溴酸、冰醋酸等采用四步法合成了含羟基的Schiff碱型大环化合物，然后以取代方法将此Schiff碱型大环化合物负载到壳聚糖上，得到具有特殊结构与性能的壳聚糖衍生物，并得到各中间产物的红外光谱图。

Part Ⅳ: In the light of patent, five hydroxamic acid derivatives have been designed in order to find more promising leading compound.

四、根据专利，我们仿制了五个羟肟酸类化合物，并展开了对此类化合物的合成研究。

According to the structure-activity relationships of actinonin and the theory that drug binds with acceptor, we designed and synthesized three series of novel hydroxamic acid derivatives in which the isoxazole ring were contained. Their structures have been confirmed by 1HNMR, MS and other analytic methods.

本文就是以天然放线菌素为先导化合物，根据放线菌素的构效关系和与PDF受体结合的原理，以易得的氨基酸为起始化合物，采用了不同的合成路线设计合成了三类新的含有异噁唑杂环的异羟肟酸衍生物，并通过1HNMR，MS及其他分析方法验证了它们的结构。

Electron donating substituent CH〓, OCH〓 and 4, 5-benzo make λ〓 red shift, electron with -drawing substituent F, Cl and CF〓 make λ〓 hypsochromic shift; b The W〓 is bigger than relative symmetrical carbocyanines, and the ratio of 0-1＇ and 0-0＇ transition intensity increase with the increase of σ〓; c The absorption and the fluorescence spectra are mirror image, and the λ〓 have a good linear relationship; d The Stokes shift △λ〓 and the Hammett σ〓 constant have a good linear relationship.

研究了染料的光物理性质，①苯环上取代基影响染料的λ〓和摩尔消光系数，相对于H，给电子取代基CH〓、OCH〓、4，5-benzo使λ〓红移，摩尔消光系数减小，吸电子取代基F、Cl、CF〓使λ〓蓝移，摩尔消光系数减小；②化合物吸收峰的半峰宽较相应的对称染料的大，且振动肩部与最大吸收峰的强度比随σ〓增大而增大；③吸收光谱与荧光光谱呈镜像关系，且λ〓与λ〓呈良好的线性关系；④化合物的Stokes位移△λ〓与取代基的Hammett σ〓常数呈线性关系。

One class is CAAX-mimetic compounds with an imidazolyl residue on one end and a carboxylic group on the other connected by benzodiazepine scaffold at different positions.

连有咪唑基的苯并二氮杂草化合物，以苯并二氮杂草-2-酮为分子骨架，7位连接含有咪唑基的侧链，1位或3位连接含羧基或酯基的侧链。此类化合物模拟了CAAX配体。

It was found that the more easily systhesized and stable N, N-acetal or N, Ohemiacetal can replace N-tosyl imino ester to react with phenols in the presence of TiCl〓, and α-arylglycine derivatives were also obtained in high yields and high regioselectivity.

进一步研究发现，更易合成的N，N-或N，O-缩醛可以作为亚胺酯的替代物和酚类化合物发生傅克反应。路易酸TiCl〓能有效地促进酚类化合物和亚胺酯的傅克反应较高产率、较高区域选择性的得到2-羟基α-芳香甘氨酸衍生物。

All the three ternary compounds formed in the title systems are new compounds reported for the first time in this paper. They are incongruently soluble in water.

从溶度图上发现了三个未见文献报道的三元化合物，它们均为固液异组成溶解的化合物。

The process is suitable to indoles compound and sulfur imides compound with different models, has mild reaction condition and simple operation.

该方法可适用于多种不同类型的吲哚类化合物和磺酰亚胺类化合物，反应条件温和，操作简便。

In recent years, a series of novel indoline derivatives which showed potent inhibitory activities for the human 5 a -reductases have been discovered.

近年来人们又发现，一系列二氢吲哚氧苯甲酸类化合物对5α-还原酶具有强力的抑制作用，于是我们试图对这类化合物进行一些探索。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。