化合物

Five types of compounds were synthesized via modification of the leading compounds, Mannich bases of cyclopentanones. Among the target compounds, one type was aromatic amine derivatives of a leading compound, three were Mannich bases of a - benzylidene cyclopentanone, the fifth was a Mannich base of a - benzyl cyclopentanone.

以具有抗炎活性的环戊酮Mannich碱为先导化合物进行结构改造，设计合成了一类已知化合物的芳胺Mannich碱衍生物，三类α-苯亚甲基环戊酮Mannich碱类化合物，一类α-苄基环戊酮Mannich碱类化合物。22个目标化合物的结构经核磁共振氢谱、红外光谱和质谱检测确证。

Then, inhibition mechanism and the relations between inhibition efficiency and molecular structure of inhibition of carbon steel in chlorhydric acid by benzene nitriles and quaternary ammonium salts are studied from microscope through quantum chemistry calculation, and according to the results, theory predicting and proof testing of a benzene nitrile (2-benzo butyl nitrile) are made.

利用Hansch关系的研究结果表明，苯腈类化合物在盐酸溶液中对碳钢缓蚀的缓蚀效率，可用苯腈类化合物氰基氮原子的净电荷密度和分子最高占据轨道能量或分子最低空轨道能量构成的表达式表达。量子化学计算研究结果表明：1、苯腈类化合物在盐酸溶液中对碳钢缓蚀的缓蚀机理可能是：苯腈类化合物分子以其氰基氮原子上的电子提供给铁的3d空轨道，形成配位键；同时铁的3d轨道上的电子提供给苯腈类化合物分子的能量最低空轨道，形成&反馈键&。

The preparation method comprises removing benzyl of the compound IV0 in alkali condition to obtain the compound (V, reacting the compound with benzyl chloroformate to obtain the compound, wherein the compounds can be used to prepare 5-substituted-hydride indolizine natural alkaloids.

本发明所提供的制备方法是将化合物在碱性条件下去苄基得到的化合物，将化合物与氯甲酸苄酯反应，生成的化合物。和化合物可以用于制备5-取代-氢化中氮茚天然生物碱。

The target compounds were obtained in high yield through Michael conjugative addition of amines to methyl acrylates, cyclocondensation of the obtained diadducts in the presence of sodium methoxide,and decarboxylation of the cyclocondensation products in acid.

以胺类化合物为原料，与丙烯酸甲酯经过两次Michael加成得到N，N 二丙酸甲酯类化合物，该化合物在甲醇钠存在下进行环合，在酸性条件下脱羧，高收率得到4 哌啶酮类化合物，从而证明了这是一条合成N 取代 4 哌啶酮类化合物的普遍方法。

Utilizing 6 and several kinds of diazides prepared in our lab, polys containing 1,2,3-triazolyl and perfluorocyclobutane units were synthesized by "Click chemistry". Utilizing the polycondensation reaction between 6 and several commercially available aromatic diphenol or copolymerization reaction after adding another active aromatic dichloride, fluorinated polys containing phenylphosphine oxide units were synthesized. Utilizing the polycondensation reaction between 6 and several commercially available aromatic dianhydride, fluorinated polys containing PPO units were synthesized.Secondly, structure characterization of fluorinated polys.

利用化合物6同各种自制的二叠氮化合物，通过&Click chemistry&，合成了具有1，2，3-三唑环结构单元的全氟环丁基类聚芳醚；利用化合物22同各种商业化的芳香二元酚类化合物进行缩聚反应或者再加入另外一种活性芳香二氯代物进行三元共聚反应，制备了具有苯基氧膦结构单元的含氟聚芳醚；通过化合物25同各种商业化的芳香二元酸酐类化合物进行缩聚反应，得到了具有PPO结构单元的含氟聚醚酰亚胺。

As a part of a search for new antitumor agents from Chinese medicinal plants, the roots of Salvia prionitis, collected in Jiangxi Province, was investigated. From the roots of this plant, a new diterpene, saprirearine (95), a new anhydride-type compound, saprionide (96), a new 7, 8-seco-abietane diterpene derivative, 7, 8-seco-paraferruginone (99), and a new 4, 5- seco-5, 10-friedo-abietane diterpenoids, 3-keto-4-hydroxysaprorthoquinone (102), have been isolated along with 6 known compounds. Their structures were established by spectroscopic methods and chemical transformation.

在对红根草的乙酸乙酯提取物进行分离，纯化和结构研究中，共得到10个化合物，其中4个是新化合物，3个新化合物具有新颖的重排松香烷型二萜骨架，新化合物99为首次从本属植物中分得的7，8-开环的松香烷型二萜醌类化合物。

The organoboron compounds in this paper are based on triarylboranes, boronic acids and boronic esters. The structure-property relationship and sensing mechanism are elucidated. Organoboron compounds as Lewis acid can be used as fluoride probe with high sensitivity and selectivity because they have a unique LUMO in which the π-conjugation is divergently extended through the vacant p-orbital of the boron atom. The complexation of the boron π-electron systems with fluoride ion would interrupt the π-conjugation extended through the boron atom, causing the change of photophysical properties.

介绍了基于三芳基硼化合物、硼酸和硼酸酯的有机硼化合物在氟离子检测中的应用，评述了这些化合物的结构和检测性能之间的关系，讨论了检测机理，即有机硼化合物中硼原子空的p轨道使其作为路易斯酸能够选择性地结合氟离子，硼原子与氟离子的结合破坏了硼中心与芳香取代基的p-π共轭，引起有机硼化合物光物理性质的变化，从而实现对氟离子的高选择性检测。

Compounds, including 15 new C21 steroids, were isolated from the alcohol abstracts of the ratten of Marsdenia tenacissima. 37 of them are C21 steriods and their glycosides, the rest 5 compounds are lignans.

从通光散藤茎的乙醇提取物中，共分离得到42个化合物，其中包括C21甾体及其甾体皂甙类化合物37个，木脂体类化合物5个，有15个新化合物，均为C21甾体类化合物。

Based on relative literatures,this part has included five resesearch aspects as below.1 Fifteen compounds were isolated and purified by extraction,column chromatography,and their structures were determined on the basis of spectral analysis: acteoside(Ⅰ-1),isoacteoside(Ⅰ-2),crenatoside(Ⅰ-3),cistanoside F(Ⅰ-4),sinapoyl-4-O-β-D-glucoside(Ⅰ-5),adenosine(Ⅰ-6),β-siterol(Ⅰ-7),oleanic acid(Ⅰ-8), succinic acid(Ⅰ-9),caffeic acid(Ⅰ-10),protocatechuic aldehyde(Ⅰ-11),p-hydro xybenzyl alcohol(Ⅰ-12),β-daucosterol(Ⅰ-13),D-galacitol(Ⅰ-14),D-mannitol(Ⅰ-15).Ⅰ-4～15 were obtained from this plant for the first time,andⅠ-6,7,9,and 13 were isolated from Orobanche genus for the first time.2 The scavenging test of DPPH showed that most compounds have comparative antioxidant activity as L-ascorbic acid and part of them show better activity such as the O.coerulescens extract and phenylethanoid glycosides.Acteoside showed potent free radical scavenging effects with a median inhibition concentration of 25.6μg/ml.3 The anti-HBV activities of acteoside,isoacteoside and crenatoside were measured,and all of them showed suppressive activity on the expression of HBsAg and HBeAg in the HepG2.2.15 cell line.

本论文在文献调研基础上对紫花列当化学成分及生物活性进行了研究，并从免疫抗病毒角度探讨紫花列当中特征性成分类叶升麻苷的肝保护作用及其机制。1采用大孔树脂、硅胶和Sephadex LH-20等色谱技术对紫花列当进行系统的植物化学研究，从中分离得到19个化合物，利用UV和NMR等波谱手段及理化性质鉴定了其中的15个化合物，分别为类叶升麻苷(Ⅰ-1)、异类叶升麻苷(Ⅰ-2)、crenatoside(Ⅰ-3)、cistanoside F(Ⅰ-4)、sinapoyl-4-O-β-D-glucoside(Ⅰ-5)、腺苷(Ⅰ-6)、β-谷甾醇(Ⅰ-7)、齐墩果酸(Ⅰ-8)、琥珀酸(Ⅰ-9)、咖啡酸(Ⅰ-10)、原儿茶醛(Ⅰ-11)、对羟甲基苯甲酸(Ⅰ-12)、β-胡萝卜苷(Ⅰ-13)、D-半乳糖醇(Ⅰ-14)和甘露醇(Ⅰ-15除化合物Ⅰ-1、Ⅰ-2和Ⅰ-3外，其余化合物均为首次从该植物中分离得到。2)通过大孔树脂富集该药材有效部位苯乙醇总苷，并采用HPLC测得其所含特征性成分类叶升麻苷的含量可达80%以上。3DPPH自由基清除试验显示紫花列当提取物及其所含的苯乙醇苷类化合物均具有较好的抗氧化能力，其清除DPPH自由基能力接近于抗坏血酸。4采用卡介苗整体致敏、脂多糖离体攻击构建大鼠原代肝细胞免疫性损伤模型，在体外观察类叶升麻苷的保肝作用。

To discover new strobilurin analogues with high pesticidal activity, a series of new strobilurin derivatives containing substituted pyrazole and pyrimide ring, which included 124 novel compounds (73 compounds containing substituted pyrazole ring and 51 compounds containing substituted pyrimide ring) were designed and synthesized. In addition, 36 new intermediates were synthesized. Their structures were characterized by ~1H NMR and elemental analysis, partial compounds were characterized by MS and IR once again.

为了发现具有更好生物活性的新型Strobilurin类化合物，本论文在详尽总结文献的基础上，设计并合成了含吡唑和嘧啶环的新型Strobilurin类化合物124个，其中含吡唑环的新型Strobilurin类化合物73个，含嘧啶环的新型Strobilurin类化合物51个；未见文献报道的中间体36个，所合成的化合物经过~1H NMR、IR、LC-MS或元素分析等确定了结构。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。