化合物

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

Covalent modification of four isolated alkannin derivatives (alkannin, acetylalkannin,β,β dimethylacrylalkannin and β acetoxyisovalerylalkannin, respectively) on rabbit muscle latate dehydrogenase and yeast Alcohol Dehydrogenase has been studied.

为研究紫草萘醌类化合物的细胞毒性作用机制，从新疆软紫草根中分离出四种紫草萘醌类化合物β，β二甲基丙烯酰阿卡宁(1)，乙酰阿卡宁(2 )，β乙酰氧基异戊酰阿卡宁(3)和阿卡宁(4)。

Firstly, one of the two key intermediates, tetrahydrofuran fragment with aterminal alkyne 27, was prepared from D-glucose utilizing a multiple-step sequencedeveloped by us earlier.

在本组过去的工作基础上，我们从葡萄糖出发，获得了含有四氢呋喃环的炔化合物27。同时，从木糖及炔丙醇出发，获得了一端为γ内酯环的烯基碘化合物14，即C1-C13片断。

Results showed that the alkynol compounds were transformed to the corresponding alkyne aldehyde and acetylenic acid compounds containing conjugated system on the nickel anode, and hence the anodic oxidation reaction products were able to generate ultraviolet absorption.

结果表明，炔醇类化合物在阳极生成了相应的有共扼体系的炔醛类和炔酸类化合物，产生了紫外吸收。

Ce2(SO4)3 was used as an inexpensive and effective catalyst for the Friedel-Crafts alkylation of aromatic compounds with benzyl alcohol s, allyl alcohols and benzyl chlorides.

硫酸亚铈作为一种便宜的和有效的催化剂催化芳香化合物与苄基醇、烯丙醇类化合物和苄基氯的傅-克烷基化反应。

Ce2(SO4)3 was used as an inexpensive and effective catalyst for the Friedel-Crafts alkylation of aromatic compounds with benzyl alcohols, allyl alcohol s and benzyl chlorides.

硫酸亚铈作为一种便宜的和有效的催化剂催化芳香化合物与苄基醇、烯丙醇类化合物和苄基氯的傅-克烷基化反应。

In their structures, polyanions are bridged by Ln ions via the coordination of the bridging oxygen atoms and terminal oxygen atoms, forming a W–Ot′–Ln–Ob–W linkage; and through the W–Ot′–Ln–Ob–W linkage a one-dimension infinite linear chain with alternating cations and anions is formed.

在相似的合成条件下，我们向原有体系内加入顺丁烯二酸作为有机配体，合成了化合物7，其7的基本结构和化合物1-6很相似，但有一个顺丁烯二酸阴离子取代了一个NO3-离子的位置。

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

Nitrogen heterocyclics ; Oxygen heterocyclics ; Cobalt ; Ammine complexes

氮杂环化合物；氧杂环化合物；钴；氨络合物

In this paper,3-methoxy-5,6-diamino-2-nitropyridine was synthesized from 3,5-dichloropyridine by substitution,oxidation,nitration and ammoniation .

研究了以3-氯-5-甲氧基-2，6-二硝基吡啶为原料，通过甲氧化、硝化、氨化合成3-甲氧基-5，6-二氨基-2-硝基吡啶，该化合物的结构通过IR，1H NMR，MS和元素分析进行了表征，确认为目标化合物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。