化合物

In some cases, its epimer 4 was also obtained. 22 compounds were synthesized, among them 18 were new.3. Using the intramolecular Pictet-Spengler reaction to form the pentacyclic skeleton of Et-743, the byproducts 25 were obtained under various conditions. The structures of them were determined to be 1, 2-dihydro-isoquinoline compounds, and the mechanism of the reaction was proposed.B. The synthesis of the analogs of Et-743Because of the failure of removing the protective groups in compounds 14, the synthetic strategy was adjusted.

对于苄基保护的羟基化合物13a，顺利得到化合物30，然后与不同的羧酸反应得到18个酯化合物33-50；对于苄氧羰基保护的氨基化合物13b，由于脱除保护基的化合物31在空气中不稳定，所以我们采取不经分离纯化，直接与羧酸反应得到酰胺化合物53-62，然后再分别对其C-21位的羰基进行还原氰基化，得到10个酰胺目标化合物63-72，另外，我们还对羟基转化为氨基的反应进行了探索。3。

Compounds 1 and 2 were new xanthones, and compound 3 was isolated as a natural product for the first time, and compounds 4 and 6 were isolated for the first time from this genus. The antioxidant activities of all compounds were evaluated by ABTS,FRAP and DPPH assays respectively. Compound 9 showed significant activity by the ABTS and FRAP assays. Compound 1 showed significant activity with IC50 value of 0.31 mg·L-1 in DPPH assay.

化合物1，2为新化合物，化合物3为新天然产物，化合物4，6为首次从该属中获得；化合物9在ABTS和FRAP模型中显示出显著的抗氧化活性；化合物1清除DPPH自由基能力的IC50为0.31 mg·L-1。

Enaminones are also valuable precursors for α-iodol enaminones, 3-amino sugar derivatives, azo-compounds,β-aminoketone, as well as tetrahydropentalenes, tetrahydroindenes, and hexahydroazulenes.

烯胺酮类化合物同时也是α-碘代烯胺酮类化合物、3-氨基糖衍生物类化合物、氮杂化合物、β-氨基衍生物类化合物和四氢并环戊二烯类化合物和四氢茚类化合物的重要前体。

Accord- ing to the observation that the compounds were stable in low pH aqueous solution and their sta- bility decreased when pH increased, and they rapidly decomposed to form α-methylenecyclopen- tanones derivative when pH reached 6 to 7, we postulated that the compounds were unabsorbable in stomack (where pH1-3) and unstable in small intestine (where pH5-8). The decomposed product was indeed inactive.

对Ⅰ类化合物在稀溶液中的稳定性研究表明，低pH时化合物较稳定，随着pH值的升高稳定性逐渐降低，pH6~7时，化合物迅速分解成α-亚甲基环戊酮类化合物，由此而推测Ⅰ类化合物经口给药无效的原因为：它们在强酸性的胃中（pH1-3）呈离子状态，因而不易吸收，经胃的排空运动进入肠道后，随着pH逐渐升高（pH5-8）化合物迅速分解，而分解产物α-亚甲基环戊酮类化合物证明是无效的。

These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

这些分子作为潜在的KARI抑制剂为基于KARI的农药分子设计提供了有利指导；对部分小分子进行了合成，在除草活性初筛的近三十个化合物中，个别化合物表现出较好的除草活性，其中一个化合物wb1596对油菜和稗草具有较高的生长抑制率，并通过E.coli KARI酶活性抑制试验验证了其KARI酶的作用靶标，此化合物可以作为KARI一个有苗头的抑制剂为后续工作奠定了基础；对发现的有苗头的KARI抑制剂进行了结构修饰和优化，合成了一系列脒类化合物并确证了它们的结构，改造后的化合物与原抑制剂相比大多除草活性相当或更佳，从而表明我们基于靶标结构的分子设计的合理可靠性；对所合成一系列脒类化合物进行了分子对接和三维定量构效关系研究。

Hexaazatriphenylene derivatives were designed and synthesized by introducing methoxyphenyl or fluorenyl peripheral aryl substituents,and the effect of these aromatic substituents on their optical properties and bandgap were characterized by means of UV-Vis absorption spectroscopy,fluorescence spectroscopy and electrochemical cyclic voltammogram.

结果发现，芴和甲氧基苯芳香基团的引入使三亚吡嗪化合物的接收电子能力显著提高，LUMO能级从化合物1a的-3.50 eV降低到化合物1b的-3.68 eV和化合物1c的-3.66 eV，并伴随着吸收光谱和荧光光谱的显著红移，最大吸收和发射峰从化合物1a的413和432 nm红移到化合物1b的460和543 nm以及化合物1c的479和552 nm。

Notably, compounds 12–14 can be described as a 3D open–framework with nano–channels, compound 15 can be described as a 3D open–framework with double helical channels, while compound 16 can be described as a 3D heterochiral coordination polymer with double helical channels, which can be obtained by spontaneous resolution from the racemic phosphonic acid.X–ray powder diffraction analysis shows that compound 16 is a pure phase. Surface photovoltage spectroscopy of compound 16 indicates that it possesses positive SPV response in the range of 300–600 nm and shows p–type semiconductor characteristic.

值得注意的是，化合物12-14为具有一维纳米孔道结构的三维开放骨架结构，化合物15是具有双螺旋孔道的三维开放骨架结构，而化合物16是外消旋的有机膦酸配体通过自发拆分而形成的具有双螺旋孔道的多手性三维开放骨架结构。X-射线粉末衍射分析表明化合物16为纯相；化合物16的表面光电压光谱分析中，在300-600nm范围内有3个正的光(来源：ABC论文12网www.abclunwen.com)伏响应带，表明它具有p型半导体的特征；化合物16的诱导表面光电压谱进一步确定它的p型半导体的特征；磁性研究表明，化合物16中两Mn原子之间存在弱的反铁磁相互作用。

Synthesis of organic sulfuric compounds in aqueous media is carried out by: using thio-olefin compounds with carbonyl compounds, acetal/keltone, hydrazone, oxime, osazone and enamine to synthesize mercaptal/keltone compounds in aqueous media; using thio-olefin compounds with alpha-hydroxyaldehyde/keltone or alpha-halogenated aldehyde/keltone to synthesize thia-olefin derivatives in a queous media; using thio-olefin compounds with alpha, beta-unsaturated hydroxy compounds, C-C treble bond, C-N treble bond, C-C double bond, N-N double bond, C-N double bond, C-S double bond, epoxy and its derivatives, aziridine and its derivatives, cyclopropane and its derivatives and halogenated carboxy to synthesize sulfoether compounds in a queous media.

含水介质中有机硫化合物的合成方法，本发明属于有机合成方法，用硫缩烯酮类化合物与羰基化合物、缩醛/酮、腙、肟、脎、烯胺在含水介质中合成缩硫醛/酮化合物，与α-羟基醛/酮或α-卤代醛/酮在含水介质中合成噻烯类衍生物，与α，β-不饱和羰基化合物、碳碳叁键、碳氮叁键、碳碳双键、氮氮双键、碳氮双键、碳硫双键、环氧乙烷及其衍生物、氮杂环丙烷及其衍生物、环丙烷及其衍生物、卤代烃等在含水介质，中合成硫醚化合物。

RESULTS ＆ CONCLUSIONS: 8 compounds were isolated and 6 compounds elucidated as Bergarpten, Umbelliferone, Skimmianine, Kaempferol, 3,5 - Diacetyltambulin and Zanthonitrile.

结果与结论：从竹叶椒果实的脂溶性部位分离得到了8个化合物，鉴定了其中的6个化合物，分别是化合物1香柑内酯、化合物2伞形花内酯、化合物3菌芋碱、化合物4山奈酚、化合物5（3，5-Diacetyltambulin）、化合物6；其中山奈酚系首次从花椒属植物中分离得到。

Aroma components, including esters, alcohols , aldehydes, ketones, acids , acetals , and other compounds which respectively represented 24.6%, 14.5%, 11.6%, 17.4%, 8.70%, 17.4, 5.80% of the total aroma components were identified in 'Rosa ' strawberry fruit. and they.

栽培草莓&罗莎&成熟果实中共鉴定出69种芳香成分，主要成分为酯类化合物(17种)，占总数的24.6%，醇类化合物(10种)占14.5%，醛类化合物(8种)占11.6%，及酮类化合物(12种)占17.4%、酸类化合物(6种)占8.70%，烷烃类化合物(12种)占17.4%，其它类化合物(4种)占5.80%。2。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。