化合物

Compound 3 was obtained from Senecio kaschkarovii for the first time and, Compound 4 is a new compound. Compound 4s absolute configuration had been determined by CD, NMR and NOE.

通过CD谱及NMR、NOE差谱研究了化合物4的立体化学，并按Dreiding models构筑了该化合物分子的立体化学结构，确定该化合物应为Non-steroid型构象。

Understanding their functional properties in processed foods requires not only knowledge of the physical and chemical properties of isolated carbohydrates, but also knowledge of the reactions and interactions that occur in situs between carbohydrates and other food constituents and the effects of these changes upon food quality and acceptance.

要了解碳水化合物在加工食品中的功能特性，不仅要有单离态碳水化合物的物理、化学性质的知识，还要有碳水化合物与其它食物成分之间在加工食品中就地所发生的反应和相互作用的知识，以及这些反映变化对食品质量和食品可接受性的影响的知识。

Furthermore, a biogenesis-based synthesis of CET was developed, which realized the plausible biogenetic transformation by a transannular reductive skeletal rearrangement of cyclic amino enone 45 to key ring skeleton of CET under mild condition directly.

化合物17经Wacker氧化、环化得到重排前体不饱和酮45，45在温和的还原条件下重排得到三尖杉碱五环骨架化合物34，从而实现了三尖杉碱的全合成。第二条路线较前一条步骤更短，合成更方便，收率更高（从二酯化合物8计合成三尖杉碱的总收率可达10％）。

After chemistry and ~1H-NMR,~(13)C-NMR、GC-MR、UV, IR Spectral analysis instrument synthesis appraisal compoundⅠ,Ⅱ,ⅢRespectively isβ-Sitosterol, oleanolic acid , ursolic acid; compoundⅣ,The structure is being appraised. CompoundⅠand compoundⅢare discovered for the first time from Radix Rosa davurica pall. Through pharmacognosy research and the chemical composition carries on the system to the root of Rosa davurica pall.

经化学及~1H-NMR、~(13)C-NMR、GC-MR、UV、IR等光谱分析仪器综合鉴定化合物Ⅰ、Ⅱ、Ⅲ分别为β-谷甾醇、齐墩果酸、熊果酸，其中化合物Ⅰ和化合物Ⅲ为首次从山刺枚根中发现。

Free tryptophane, docosoic acid and methyl 14-methy pentadecanate were isolated and identified as monomeric compounds also for the first time from Panax plants. Malonyl-ginsenoside 〓, ginsenoside Ro,〓, Re,〓,〓,〓(8 saponins) and stigmasterol were isolated and identified for the first time from the fruits and molonyl- ginsenoside 〓 was also the first from the plant of panax quinquefolium.

游离色氨酸、二十二碳酸及14-甲基-十五碳酸甲酯是首次从人参属植物中分离鉴定的杂环α-氨基酸和脂肪羧酸类单体化合物；丙二酸单酰基人参皂甙〓、人参皂甙〓及豆甾醇是西洋参果中首次分离鉴定的8种单体皂甙和1种甾醇化合物，M-〓亦为西洋参中首次分离鉴定的皂甙化合物。

The result showed that caffeic acid (PA4) and 3-O-coumaroyl-β-sitosterol (PE1) appeared to be most synergistic compounds for combining with other compounds and chlorogenic acid (PA6) was the most antagonistic compound with other compounds on the growth inhibition of A549, a human lung cancer cell line; while any 2-compound combinations of palmitic acid, 5-hydroxy-7-methoxy- 4'-acetylisoflavone and stigmasterol (S1) appeared to be synergistic on the growth inhibition HT-29, a human colorectal cancer cell line.

由两种化合物组合的结果发现，咖啡酸(caffeic acid；PA4)或3-O-coumaroyl-β-sitosterol (PE1)与其他化合物组合时，对於抑制A549细胞增生方面有相乘的作用，另一方面，绿原酸(chlorogenic acid；PA6)与其他化合物组合时，有强烈的拮抗作用。

The bulky substituent at position 6 and 7 is beneficial to increase the inhibitory activity.

本课题组用虚拟筛选的方法，在小分子数据库中确定了82个化合物，对这些化合物进行了EGFR-TK分子水平药理测试，发现有8个化合物与EGFR-TK有较好的结合活性。

Results show that hydroxyl group existing in benzene ring, sulfanilamide being adjacent to hydroxyl group and benzene ring itself are main active sites of this kind of compounds probably. Orbit energy distributing on groups and the number of net charge of N atom determine compounds' insecticidal activity directly.

计算结果表明，该类化合物中苯环上的羟基、羟基相邻的磺胺基团以及与该苯环的组合很可能是该类化合物的主要活性部位，分布在基团上的前线轨道以及N原子的净电荷的多少直接决定化合物的杀虫活性。

Work was also carried out. From numerous facts of ourprevious work, it might be seen that the stereoselectivity of aziridination viasulfonium ylides depends upon the sulfonium salts and C=X compounds. The moreactive the sulfonium ylide and C=X compound are, the more cis product is generated.Whereas, trans product will be major if the activity of the sulfonium ylide and C=Xcompound is low.

通过对以往工作的总结，我们发现，在经由硫叶立德途径的小环化反应中有一个经验规律：产物的立体选择性与所用的锍盐和C=X化合物有关，即锍盐和C=X化合物的活性增强，有利于形成顺式产物，反之，锍盐和C=X化合物的活性降低，有利于反式产物的形成。

METHORD: The chemical constituents of Schisandra micrantha were isolated by various column chromatographic methods. Their structures were assigned by spectroscopic methods including 2D NMR experiments, and their anti-HIV-1 activities and cytotoxicities were tested by microtiter syncytium formation infectivity assay.

采用多种柱层析分离进行化合物的分离和纯化，通过波谱分析鉴定化合物的结构，化合物的抗HIV-1活性通过对HIV-1感染C8166细胞致细胞病变的抑制试验得到。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。