化

Methylcarbonate is an important organic industrial intermediate. Because its molecular structure contains carbonyl, methyl, methoxyl group and carbonyl methoxyl group, etc., it can be used in carbonylate, methylate, methoxylate organic synthetic reaction.

碳酸二甲酯是一种重要的有机化工中间体，由于其分子结构中含有羰基、甲基、甲氧基和羰基甲氧基，因而可广泛用于羰基化、甲基化、甲氧基化和羰基甲基化等有机合成反应。

On the design of algorithms, a novel exact hierarchical delay analysis method for general circuits is proposed; based on the sensitization theorem for sequential circuits, an exact minimizing clocking method is proposed; based on Boolean process, a waveform simulation method considering interconnecting delay for logic circuit and a parallel waveform simulation method are proposed; a new method that transforms bit-level waveform polynomial to word-level polynomial model is proposed; a multiple valued synthesis algorithm based on multiple valued Boolean process and a wire-centered delay synthesis policy are proposed, in which timing planning, floorplanning, wire planning and optimal clock skew in early design are considered; a two-layers channel routing method for minimizing crosstalk under grid mode is proposed; based on the transition numbers theorems for waveform polynomial, a new method for generation of test with noise effects is proposed.

算法设计方面，提出了一种精确的通用电路层次化延时分析方法；基于时序电路的敏化定理提出时序电路最小时钟周期精确确定方法；提出基于Boolean过程论的考虑互连延迟的逻辑电路波形模拟方法，在分析了波形模拟适合并行化基础上，进一步提出一种并行波形模拟算法；提出一种将位级电路波形多项式描述转化成字级多项式描述的新方法；提出一种基于多值Boolean过程的多值电路综合算法以及一种将前期设计定时规划、前期设计的布局规划和线网结构化方法及低偏移的时钟分配等技术相结合的面向互连延时的综合策略；提出一种串绕最小化的网格模式下的双层通道布线方法；从波形多项式描述跳变数的定理出发提出了一种考虑噪声效应的测试生成新方法。

Its further development should follow the guidelines such as the integrity of research objects, the nativeness of thinking mode in research, the synthesization of research achievements, the applicability of research effects, and the...

努力实现体育心理学研究对象的整体化、研究成果的融合化、研究思路的本土化、研究效价的应用化和研究方法的实证化是我国体育心理学发展的合理选择

ConclusionGR mRNA upregulation in lung tissue could be one of the mechanism of glucocorticoid's effective cure for pulmonary fibrosis,and GR mRNA downregulation in lung tissue in renalyang asthenia syndrome could be one of cause of glucocorticoid's noneffective therapy for pulmonary fibrosis,in addition,the Chinese traditional medicine with warming Yang effect could be effective therapy for pulmonary fibrosis.

结论肺组织GRmRNA表达的上调是糖皮质激素防治肺纤维化之所以有效的机理之一，而肾阳虚状态下肺纤维化肺组织GRmRNA表达下调是临床上许多肺纤维化病人对糖皮质激素不敏感的原因之一，同时，温阳药也极可能具有防治肺纤维化的作用。

RESULTS A eukaryotic expression system for high expression humanmutantCD59 were successfully set up : The recombinant PALTER-MAX plasmid containing human mutantCD59 cDNA and PCDNA plasmid were co-transfected into CHO cell by cation lipoid mediating method ;and the cells were grown in F12 medium containing 400ug/ml G418 for 14 days, positive clones were grown in RPMI1640 medium to get stable expressing cell lines . Highly expressing clones were selected by flow cytometry ,and were named PALTER-CD59-CHO1PALTER-CD59-CHO2 . Flow cytometry indicated that expression rates of PALTER-CD59-CHO1 and PALTER-CD59-CHO2 were 53.7%and 54.5%. Further more, Stable highly expressing CHO cell lines were more detected by immunocytochemistry and immunofluorescence technology . PALTER-CD59 -CHO1 and PALTER-CD59-CHO2 were grown in RPMI1640 to get a large of cells . CD59 protein were obtained by spalling PALTER- CD59- CHO1 and PALTER - CD59 - CHO2 cells . Stable highly expressing cells were further validated by SDS-PAGE, immunoblot analysis and solid enzyme immunoassay . PALTER - CD59 - CHO1 and PALTER - CD59 - CHO2 were glycated in RPMI1640 of 50mM ribose for 72 hours .BCECF releasing test indicted that the releasing rate of PALTER-CD59-CHO1 or PALTER-CD59-CHO2 was less high than PALTER-CHO ,and the releasing rate of glycated PALTER-CD59 -CHOI or PALTER-CD59-CHO2 was higher than unglycated ones . PALTER -CD59-CHO1 and PALTER -CD59 -CHO2 were glycated in RPMI1640 of 50mM ribose for 72 hours .BCECF releasing test indicted that the releasing rate of PALTER - CD59 - CHOI or PALTER - CD59 - CHO2 was less high than PALTER-CHO ,and the releasing rate of glycated PALTER-CD59-CHO1 or PALTER - CD5 9-CHO2 was higher than unglycated ones .

结果 成功构建突变人CD59的真核细胞表达系统：运用阳离子脂质体介导法将含有突变人CD59的PALTER—MAX重组质粒与PCDNA共转染入CHO细胞：用含有400ug／mlG418的F12培养基培养14天，筛选出稳定阳性表达克隆，RPMI1640培养基扩增获得稳定表达细胞株，并用流式细胞术进一步筛选出高效表达细胞株分别命名为PALTER—CD59—CH01、PALTER—CD59—CH02，表达率分别为53.7％、54.5％；应用免疫组化方法、免疫荧光技术进一步鉴定阳性细胞株；RPMI1640培养基大量扩增PALTER—CD59—CH01、PALTER—CD59—CH02细胞株，裂解细胞得到CD59蛋白质；通过SDS—PAGE凝胶电泳技术、免疫印迹技术、固相酶联免疫吸附试验验证了这两中文摘要个阳性细胞株CO59蛋白的高效表达；50mM核糖培养72小时，获得突变人CD59糖化细胞株，BCECF染料释放试验结果显示，PALTER一CD59一CHOI、pALTER一CD59一CHOZ细胞较PALTER一CHO细胞染料释放率低，未糖化PALTER一CD59一CHOI、PALTER一CD59一CHOZ细胞比较糖化后细胞染料释放率低。

In this paper,investigation has been made on the process for the synthesis of salicylaldehyde by esterification-oxidation with phenol,paraformaldehyde,boric acid as initial materials.

探索了以苯酚、硼酸和多聚甲醛为原料的酯化氧化法合成水杨醛的工艺路线，根据反应特点，改进了酯化反应方式，采用了多聚甲醛气态解聚法作为羟甲基化反应的进料方式，探讨了羟甲基化反应温度、多聚甲醛原料含水量、催化氧化反应催化剂用量对反应收率的影响并得到最佳反应条件，水杨醛收率为60.5%，纯度达98%以上。

This course will introduce the basic theory of parallel computing, teach how to identify problems that are parallelizable, and demonstrate how to apply the principles of parallel computing to civil engineering problems. Students will have opportunities to obtain hands-on experience by developing their own parallel programs. The prerequisite of this course is computer programming. It is suitable for graduate students to choose as an elective.

在本课程中将介绍平行运算的原理（Concurrency and Synchronization），分辨可平行化和不可平行化的问题，探讨平行运算的演算法和可计算性，以及介绍将程式平行化的实用技术，并分析程式容错性和可靠度（Fault Tolerance and Reliability），以帮助学生将平行运算应用在土木工程和学术研究中，学生将有机会使用平行化程式语言开发应用程式，本课程先修课程为程式设计，建议研究所同学选修。

Space curve is one of the basic elements in geometric modeling, and its effective representation is the basis of modeling. Parametric representation based on features is a kind of high-level representation including semantic information. In Chapter 4, para- metric representations based on features for free form space curve are investigated, and a parametric model for the loop of plain knitted fabric is established, in which 5 parameters with practical meanings are used to represent the shape of a loop and the relationship between loops. A new shrinkage prediction method for knitted fabric are proposed based on the parametric representation and energy minimizing. Experimental results on some plain knitted fabrics illustrate the feasibility of the proposed method.

空间曲线是造型中最基本的几何元素之一，对其有效的表示是造型的基础，而特征参数化表示是其中一种包含语义信息的高层次表示，本文对空间自由曲线的特征参数化表示进行研究，建立了一种针织物线圈的特征参数化几何模型，采用5个具有实际意义的参数表示织物线圈的几何形状及线圈之间的位置关系，并将该模型与能量极小化的方法相结合，得到了一种能较好地预测针织物缩水率的新模型，对随机选取的一些针织布缩水预测实验表明了算法的可行性。

The effects of the corrosive accelerator,acid ratio,phosphatizing temperature,phosphatizing time and the additives on zinc phosphatization of aluminum alloy were investigated.

以LY12铝合金为试样，讨论了腐蚀加速剂、酸比、磷化温度、磷化时间、磷化添加剂对铝合金磷化的影响，得出了相应的最佳工艺参数。

In this process, the phosphatization is incorporated to increase the thickness of the film, and the transition element salt is used as blacken agent to take the placeIIof soluble silver or cOPper salt.

采用非银盐、铜盐发黑剂，系统研究了锌镍合金镀层的黑色钝化工艺，并将磷化工艺结合进钝化中，得到了厚膜型钝化膜。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。