化

Decabromodiphenyl oxide,tetrabromobisphenol A,sodium bromide,sodium bromate,potassium bromide,ammonium bromide,calcium bromide,calcium chloride,magnesium chloride,sodium bicarbonate,magnesium hydroxide,manganese bromide,hydrobromic acid,salt etc.

提供产品：十溴二苯醚、四溴双酚A、溴化钠、溴酸钠、溴化钾、溴化铵、溴化钙、氯化钙、氯化镁、碳酸氢钠、氢氧化镁、溴化锰、氢溴酸、盐等。

The result of immobilization showed that hydrophile membranes were more advantageous than hydrophobe ones to act as immobilization carrier. Crosslinking organophosphorus hydrolase by glutaraldehyde on polyethersulfone membrane is a simple and practical immobilization method. An appropriate amount of bovine serum albumin and crosslinker is necessary to get a good result of immobilization. In the biodegradation of methyl-parathion through enzyme membrane reactor, the effect of immobilized enzyme amount, flow rate of peristaltic pump, pH of the feed, and the methyl-parathion concentration on biodegradation rate was studied. It was shown that the biodegradation rate increased with immobilized enzyme amount and substrate concentration. Biodegradation rate didn't increase when the folw rate of the peristaltic pump was larger than 7 ml/min.

然后，研究固定化酶降解甲基对硫磷，从不同材料的膜载体固定有机磷水解酶的比较中，发现亲水膜比疏水膜适合作固定化酶载体；在此基础上，将有机磷水解酶固定在聚醚砜微滤膜上，并制成酶膜生物反应器，用于降解甲基对硫磷；戊二醛化学交联法固定时，酶液与10%牛血清白蛋白溶液的比例在3：1~2：1，与交联剂的比例在7：2~7：4范围内，固定化效果较好，并发现牛血清白蛋白和膜载体有降低酶活损失的作用；将固定化的酶膜装于酶膜反应器降解甲基对硫磷，实验结果表明：反应器的降解速率与固定化酶量呈正比，也随底物浓度的增加而加快，当流速低时，降解速率随流速增大而加快，到7ml/min以上时，降解速率不随流速脑黾佣洌到獾淖畹团ǘ任？

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Chiral centers of C5 and C8 are directly constructed in the key step of the diastereoselective propargylation from D--tartrate. The methylation and subsequent methoxycarbonylation result in desymmetrization of the terminal dialkynes. The α,β-unsaturated δ-lactone is synthesized after partial hydrogenation and lactonization.

由非天然酒石酸出发，利用双向非对映选择性的炔丙基化反应，在一步反应中同时构建C5和C8手性中心；然后通过末端炔基的甲基化、甲酯基化，延长碳链并对分子去对称化；内酯化得到关键中间体α，β-不饱和六元内酯，再经多步反应转化得到8-epi--Boronolide。

The effects of several components in the culture medium on Lithospermum erythrorhizon cell growth and secondary metabolite synthesis were studied, as well as structural dynamic model. The two-liquid-phase culture of Lithospermum erythrorhizon was carried out by choosing the proper organic solvent as the second phase. The bioactive carrier for adsorption was prepared and the condition of cell immobilization was determined. We combined the technique of two-liquid-phase culture and immobilization to carry out the culture. We chose the suitable type of reactor, studied its characteristics and results of cell culture using this reactor. The fed-batch operation was also studied on the basis of twoliquid-phase culture and immobilization used in culture in the reactor.

本文研究了紫草细胞悬浮培养中培养基中多种成分对细胞生长与次生代谢产物合成的影响，进行了结构化的动力学模型研究；通过选择合适的有机溶剂对紫草细胞进行了双液相培养研究；通过确定以吸附为细胞的固定化方法，进行了生物活性吸附载体的制备与固定化细胞的制备研究；并结合双液相培养技术，对紫草细胞进行了固定化培养及其动力学模型的研究；对反应器进行选型，并进行冷模与热模研究；在反应器中进行了固定化紫草细胞的双液相培养条件下的流加操作研究。

The result indicated that: the amount of the excess HF formed direct ratio to the yield of phosphorus pentafluoride and the optimum amount of the excess HF used is about 35%; the trickling rate of oleum shouldnt make the temperature of hexafluorophosphoric acid exceed 25 ℃ and the amount of oleum is 110% to 125% that of stoichiometry so that the content of phosphorus pentafluoride can be achieved 90%; the time and temperature of heating hexafluorophosphoric acid influenced both the yield and the content of phosphorus pentafluoride, and the optimum time should be about 30 minutes and the proper temperature was 148 to 153℃; when alcohol used asrefrigerant, the content of phosphorus pentafluoride was 94.03%, and the content can be up to 97.38%, provided that using liquid nitrogen as refrigerant.

通过实验发现，氟化氢用量与五氟化磷的产率成正比，最佳过量百分率宜在35％左右；发烟硫酸的滴加速度不能使中间产物温度大于25℃，发烟硫酸用量大于理论量10％～25％时，得到的五氟化磷纯度高于90％；六氟磷酸的加热温度对五氟化磷的产率和纯度均有影响，宜在148～153℃的范围内，加热时间应在30分钟左右；用工业酒精做冷凝介质得到的五氟化磷纯度最高只能到达94.03％，使用液氮做冷凝介质可以使五氟化磷的纯度达97.38％以上。

In order to improve the Solubility of PSPI, a series of cocondensation type PSPIs that end-capped with HEA have been synthesized from phyromellitic dianhydride, 4,4'-diaminodiphenyl ether, dimethyl phenylamide and diamino-diphenyl sulphone.

在亚胺化过程中，随酰亚胺化时间的延长，酰亚胺化温度的增高，亚胺化速率变快，亚胺化程度增高。

At each level, the parameters, hyper parameters and model parameters are adjusted to minimize the Kullback-Leibler divergence between their posteriors and real distributions so that the variable free energy can approach the real free energy.

在指出证据框架和自由能最小化方法等贝叶斯推理方法的局限性的前提下，通过对比证据框架的方法，提出了自由能框架的概念，将通常难以求解的自由能最小化过程分解成参数自由能最小化、超参数自由能最小化、模型参数自由能最小化等层次，在每个层次上调节参数、超参数和模型参数，使其后验分布为其真实分布之同的Kullback-Leibler距最小，以使可变自由能逼近真实自由能。

Methyl 6-acylnaphthalene from 2-methylnaphthalene was synthesized via acylation using acetic anhydride and propionyl chloride as the acylating agents with catalyst aluminum trichloride in homogeneous liquid phase system.

为制备重要的化合物2-甲基6-酰基萘，提高酰化产物的收率和纯度，以2-甲基萘为原料，分别研究了乙酸酐和丙酰氯为酰化剂时的酰化反应，对酰化反应的产物进行了GC、FT-IR和GC-MS表征；对酰化反应的影响因素进行了研究。

In ore body, K-feldsparization is widely distributed, silication ispockety, the other alterations have obvious vertical zoning, from upper to lower is:biotite zone→sericite zone→propylitic zone (epidote-chlorite-calcitization zone).

在空间上，钾长石化分布较广，硅化分布不均，其它蚀变垂直分带现象比较明显，由下至上是：黑云母化带→绢云母化带→青盘岩化(绿泥石-绿帘石-方解石化)带。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。