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Process for the preparation of phosphatidylserine of formula wherein R and R independently represent a saturated, mono-unsaturated or polyunsaturated acyl C10-C30, X=OH or OM where M=alkaline or alkaline earth metal, ammonium, alkylammonium including the transphosphatidylation reaction between phosphatidylcholine of the general formula wherein R and R and X have the above specified meanings, R=CH2-CH2- NH2 o CH2-CH2-N(CH3)3 and Serine in D, L or racemic form catalysed by the phospholipase D enzyme, characterised in that said reaction is carried out in a hydroalcoholic medium containing an aliphatic alcohol and in the presence of bivalent metal oxide.

本发明涉及制备式CH 2 OR 1 CHOR 2 CH 2 O-P-OCH 2 -CH(NH 2 )-COOHX的磷脂酰丝氨酸的方法,其中R 1 和R 2 独立地表示饱和的、单不饱和的和/或多不饱和的酰基C 10 -C 30 ,X=OH或OM,其中M=碱或碱土金属、铵、烷基铵,该方法包括通式CH 2 OR 1 CHOR 2 CH 2 O-P-OR 3 X的磷脂酰胆碱其中R 1 和R 2 以及X具有上述特别的含义,R 3 =CH 2 -CH 2 -NH 2 或CH 2 -CH 2 -N (CH 3 3 与D、L或外消旋形式的丝氨酸之间的转磷脂酰化反应,该反应是通过磷脂酶D酶催化的,其特征在于所述的反应是在包含脂族醇的含水醇介质中并且在二价金属氧化物的存在下进行的。

The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

此外,本发明提供了药物组合物,其包含所述的异羟肟酸异羟肟酸衍生物,本发明还提供了这些药物组合物的安全的剂量给药方案,其可以容易地遵照,并且其在体内产生该异羟肟酸衍生物的治疗有效量。

Moreover, such links to third party web-sites or databases does not indicate, either expressly or impliedly, that the Licensor has been endorsed by the owners of those web-sites or databases, and the Licensor shall not be liable to or responsible for any information contained therein or the use or inability to use such information.

此外,这些与第三方网站或是数据库的链接并非明确或隐含地表示许可方已经与这些网站或是数据库的所有者签署了协议。进而,许可方不对其中包含的任何信息、使用或是不能使用这些信息承担任何责任和义务。

Vehicle headlamp provided with a metal halide lamp comprising a discharge vessel surrounded with clearance by an outer envelope and having a ceramic wall which encloses a discharge space containing xenon and an ionizable filling, wherein in said discharge space two electrodes are arranged whose tips have a mutual interspacing EA so as to define a discharge path between them, wherein the discharge vessel has an internal diameter Di at least over the distance EA, and wherein Di is smaller than or equal to 2 mm and the relation EA/Di is smaller than 6, with the special feature that said vehicle headlamp has not more than one band-shaped light-absorbing coating laterally of the discharge path.

一种配置金属卤化物灯的车辆前灯包括:放电容器,其被外壳有间隙地包围,其具有陶瓷壁,所述陶瓷壁封闭包含氙和可电离填充物的放电空间,其中两个电极布置在所述放电空间内,所述电极末端具有相互间隔EA,因而在它们之间定义放电路径,其中放电容器至少沿着距离EA具有内径Di,其中Di小于或等于2mm,以及关系式EA/Di小于6,其特征在于,所述车辆前灯放电路径的侧向方向具有至多一条带状光吸收涂层。

Results We obtained a lysogenic bacteriophage MZTP01with clear plaque and 1 mm diameter. Fragment D with 2362bp (Genebank No. AY639599) was obtained after the phage DNA hydrolyzed by HindⅢ/EcoRⅠ. Among fragment D, the pep gene with molecular weight of 47 kDa and length of 1101bp was cloned and expressed. Recombinant M15 (pQE30pep) was built and overexpressed in Escherichia coli with a 47kDa clear band. At the same place a clear band was observed by Western blot. Judging from the time course expression, we could conclude that PEP protein produced at 1 hour after induction and then increased gradually. PEP protein was mainly in the form of inclusion body in the recombinant and slowed the growth speed of host. Homologous comparison of PEP protein from phage MZTP01 with other PEPs from BLAST were that phage MZTP01 PEP protein had 100% homologe with that of Escherichia coli K12, and most of others took the similarity in the range between 37%~84%.

诱导获得的溶原性噬菌体MZTP01斑点清晰,直径约1mm,成斑时间12h;从噬菌体基因组DNA双酶切(HindⅢ/EcoRⅠ)片段中回收长度为2362bp的D片段(Genbank登录号: AY639599),又从D片段中克隆了长度为1101bp、编码367aa、分子量为47kDa的pep基因,表达载体M15(pQE30pep)在大肠杆菌(Escherichia coli, E.coli)中表达获得了47kDa的清晰表达带,在1h 时开始产生蛋白并有逐步上升的趋势; Western blot 也在47kDa处得到一条清晰的条带;可溶性分析表明PEP蛋白在重组菌株中是以不可溶的包含体形式存在的,该蛋白的产生明显地抑制了宿主的生长速度;噬菌体PEP氨基酸序列之间的同源性比较表明,噬菌体MZTP01 PEP蛋白与来自E.coli K12噬菌体的PEP蛋白的同源性程度最大。

The creative point of this dissertation consists firstly in that monochromatic stimuli instead of combined spectral power distribution were used as visual object, and spectral luminous efficacy curves were drawn from the performance-based method; Comparison between performance-based method and brightness-matching method was then done and therefore connection between these two methods was developed; One more creative point is that the analysis based on the theory of neurophysiology and psychophysics leads to the conclusion that contribution of the colour channel during visual information processing is reflected from performance-based method, which should be considered when CIE develops the new mesopic photometry system.

论文的新颖之处在于实验中使用了单色光谱代替复合谱或物体色作为视觉目标,在分析中间视觉状态下视觉功能的光谱响应特性的基础上反推了人眼的光谱光视效率函数;论文更进一步验证了基于视觉功能法和传统的视亮度匹配法之间的联系,在两种方法之间构造了一座桥梁,为基于视觉功能法的使用初步建立了理论依据;同时论文创新地采用心理物理学的方法进行实验和结合物理学和视神经生理学的知识对实验结果进行分析,从而从视觉信息处理的神经机制层面证明了基于视觉功能法获得的结果包含了视觉颜色通道效应,并对CIE在建立新的中间视觉光度学系统时要充分考虑这一视觉颜色通道的影响提出了建议。

Multiangular remote sensing is capable of providing more three-dimensional information of vegetation, and it is powerful in obtaining the parameter of the plants.

多角度遥感包含了大量的地面目标的立体结构信息,具备求解植被特征参数的潜力,但通常多角度遥感反演对光谱信息的利用不足。

There is also some disto-rtion on that track from overmodulation that is part of the reco-rding, and the C-2C is transparent enough that this is audible (pity they didn't reco-rd it better, such great music).

这录音也包含有一部分过载失真,C2C 足够清晰地还原了这些(可怜他们有这么好的音乐却录音太差)。

Hartert's Leaf Warbler (formerly included with "Blyth's") Phylloscopus goodsoni (polytypic, with apparently race fokiensis in SE China).

之前包含在冠纹柳莺,多型种,其中中国东南部有明显地 fokiensis 亚种。

By bestowing rich philosophic and symbolic meaning on some substances of speeial form and color ,the vajra vehicle secret mantra approach of Tibetan Buddhism brings the practician to realize the wisdom and beneficence of Buddha.

藏传佛教金刚乘密法给一些具备特定形状、色彩的事物赋予了包含丰富哲学思想内容的象征意义,通过或根据象征性的形象特征使行者体悟到如来果地的智慧与功德。

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