动脉内膜

Surface tear of the endomembrane and atherosclerotic plaque induced by balloon dilatation, mechanical expansion and carotid sinus draw-off can adjust compliance of the carotid wall, change sensitiveness of carotid artery receptor, cause instability of hemadynamics and defluxion of plaque fragments, lead to hypotension, bradycardia, hypertension and vascular embolism. How to control and reduce occurrence of above-mentioned complications is a main problem in present studies.

但由于球囊扩张、支架置入机械扩张和牵拉，颈动脉窦引起内膜和动脉粥样硬化斑块的表面撕裂，调整了颈动脉壁顺应性，改变了颈动脉受体的敏感性，引起血液动力学不稳定和斑块碎片脱落，引起低血压、心动过缓、高血压及血管栓塞等并发症，如何控制和减少上述并发症的发生是目前研究的主要问题。

The last two types were mainly distributed at the inferior segment of popliteal artery, the superior segment of anterior and posterior tibial arteries, forming vascular anastomosing network in the whole cnemis muscle group.

晚期的下肢ASO，腘动脉、胫前动脉及胫后动脉虽闭塞，但在某些固定部位仍存在未闭塞的多个侧支，一旦此段主干动脉行内膜剥脱后即可构建远端&侧支流出道&。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

Methods: After transferred pcDNA3.1/hTM plasmid into rabbit artery by high-pressure injection, rabbit common iliac artery were cut and anastomosed again. At the 14 days and 28days after second operation, we checked inside diameter of anastomotic stoma and blood flow velocity by color Doppler. The treated artery were sliced and stained by Verhoeff. Local neointima formation and the ratio stenosis of intervascular were calculated by computer.

用注射式加压转染的方式对兔动脉壁转染pcDNA3.1/hTM质粒，再制造动脉损伤-阻滞模型，于术后14天、28天用彩色多普勒观察活体吻合口内径和血流流速；再做病理切片Verhoeff染色，观察血管内膜增生的程度、部位，计算血管内膜面积、中膜面积和血管狭窄率。

Methods:Arterial intimal thickness,ABI,and hsCRP were measured in 342 patients with hypertension.

对342例高血压病患者行颈动脉内膜测量及ABI、超敏CRP测定。

In the present study, Manpreet Kanwar and co-workers from Wayne State University School of Medicine in Detroit, Michigan, hypothesized that measuring CIMT could improve the ability of EST to identify symptomatic patients with ≥50% coronary diameter stenosis.

在最近的研究中，来自密西根州底特律市Wayne州大学医学院的 Manpreet Kanwar和他的同事假设超声测量颈动脉内膜中层厚度改良运动负荷试验在鉴定≥50%冠脉直径狭窄的有症状病人的能力。

AS is a chronic inflammatory proliferative disease induced by abnormal lipometabolism.

TGF-β可能在动脉内膜被高脂血症损伤后的炎性增生反应过程中起作用。

Results In 9 cases of endometrial biopsy of materials by uterine curettage, the cells of endometrial stromal sarcomas of 6 cases were well differentiated and like stromal cells of endometrial hyperplasia; the cells of endometrial stromal sarcomas of 3 cases were poor differentiated, the cells of 2 were like that of malignant lymphoma, and another like that of pleomorphous sarcoma. In 9 cases were found the distribution of vessels cluster like endometrial corkscrew small artery. The tumor cells were grew along lymphatic or protruded in lymphatic, and there were small islands or small pieces of tumor cells in the interspace of muscles in 2 cases. The contrastive observation of the specimens of resected uterines of 9 cases confirmed the valve of above features to the confessed diagnosis of endometrial stromal sarcomas in the materials of endometrial biopsy or uterine curettage.

有3例分化差者，其中2例酷似恶性淋巴瘤，1例酷似多形性肉瘤。9例均见簇状分布的子宫内膜螺旋小动脉样的小血管分布，2例见瘤组织沿淋巴管和突入淋巴管内生长及小片平滑肌组织的肌间隙内有小灶状或小片状瘤组织分布。9例子宫切除标本的对比观察，进一步证实了上述特征对宫内膜活检或刮出物确诊子宫内膜间质肉瘤的价值。

The expression of AT2R gene can be regulated efficiently in vivo by local delivery of MSC with dual-stable expression of AT2R gene, thus reduces the formation of intimal hyperplasia.④AT2R gene can influence the expression of ECM and significantly promote the cellular apoptosis in the injury rat carotid artery.⑤These data demonstrate the clinical potential of AT2R regulatable expression to prevent restenosis after PCI.

研究结论：(1)与VSMC直接接触可以诱导MSC向血管成分细胞分化；(2)构建的Dox-on可调控的MSC细胞株诱导活性可靠，使外源AT2R基因的表达处于有效的主动控制下；(3)局部导入MSC不影响球囊损伤后大鼠颈动脉新生内膜增生；(4)由MSC介导的AT2R可调控表达受到Dox的良好调控，可有效抑制球囊损伤后大鼠颈动脉新生内膜增生；(5)AT2R影响血管损伤后修复时ECM成分的表达，并促进细胞凋亡的发生，可能是AT2R介导抑制新生内膜形成的机制。

Results:One hundred and twenty one cases (2.5%) with disease of cervical artery were found among them. Eightynine cases with intima-media thickening and 32 casas with plaque formation were diagnosed. Its coincidence was up to 100%. Detection rate of thyroid disease lesion was up to 9.2% in 428 cases of 4655 cases health screening. More nodoles goiter were found and next to thyroid cyst,thyroid adenomas,hyperthyroidism,thyrditis and thyroid cancer.

结果： 4 655例中，经超声筛查颈部血管病变121例，检出率为2.5%，其中单纯颈、椎动脉内膜-中层厚度增厚89例，合并粥样硬化斑块32例，诊断符合率为100%；筛查甲状腺疾病428例，检出率为9.2%，发病以结节性甲状腺肿居多，其次为甲状腺囊肿、甲状腺腺瘤、甲状腺功能亢进、甲状腺炎、甲状腺癌等，诊断符合率为82%。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。