动脉

There was no expression of CTGF protein in the pulmonary arteriole of the normal group, whereas, it was highly expressed in the tunica adventitia, slightly expressed in the endangium and rarely expressed in the tunica media of pulmonary arteriole in the hypoxemic group.

正常对照组大鼠肺小动脉壁CTGF蛋白未表达；低氧组大鼠肺小动脉壁外膜CTGF明显表达，内膜略有表达，中膜几乎无表达。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

The predecessors have studied a lot to the pharmaco-analysis of the puerarin from clinical.They found that the puerarin is a effective medicine for the endeictic of high blood pressure,hyperlipemia,coronary artery disease,angina cordis,cerebral thrombosis,and at the same time,the therapeutic efficacy of puerarin is very effective to preserve the arterial blood vessel endothelial,to treat the disease of artherosclerosis,to prevent the thrombogenesis.

前人多从临床的角度对葛根素进行过药理分析，发现葛根素对于高血压、高血脂、冠心病、心绞痛、脑血栓等症状的治疗效果突出，对保护动脉血管内皮细胞、阻止动脉粥样硬化，防止血栓形成的作用也十分明显。

SO2 is endogenously generated in cardiovascular system, and the SO2 content in arteries is higher than that in other organs. GOT enzyme and GOT mRNA expression are low in arteries, and this phenomenon may be related with local metabolism.

SO2可在心血管系统内源性产生，动脉血管中SO2含量高于组织器官中的含量，GOT酶及GOT mRNA的含量在动脉血管中较低，这可能与局部代谢及作用有关。

To 353 routine supersonic inspects the double side neck generalartery, in the neck moves the vessel cavity, the endophragm and uses the colored Doppler blood stream situation.

对353例行超声检查双侧颈总动脉，颈内动脉管腔、内壁并用彩色多普勒血流情况。

Among the 224 cases, 50 cases received ligation of the external carotid artery, 35 cases received ligation of the ethmoidal artery, 139 cases were treated under nasal endoscopy, and 3 cases recevied nasopharyngeal packing.

224例顽固性鼻出血病例中，50例行颈外动脉结扎，35例行筛动脉结扎，鼻内镜下治疗139例，鼻咽填塞3例。

Results During a followedup of 3 months after management, the recurrent rate of ligation of the external carotid artery was 22%, of ligation of the ethmoidal artery was 17.14%, and of nasal endoscopic surgery was 2.88%.

结果 224例中，随访3个月，颈外动脉结扎者复发率22.00%，筛动脉结扎者复发率17.14%，鼻内镜下治疗者复发率4.32%。

Result: The length of intraorbital segment of anterior ethmoidal artery was 5.16±1.24 mm,and its diameter was 0.56±0.17 mm;the length of intraorbital segment of posterior ethmoidal artery was 9.08±2.29 mm,with diameter 0.37±0.14 mm.

结果：筛前动脉眶内段长(5.16±1.24)mm，管径为(0.56±0.17)mm；筛后动脉眶内段长(9.08±2.29)mm，管径为(0.37±0.14)mm。

The hypercholesterolemic rats were selected to imitate early stage of human atherosclerosis The effects and mechanism of n-3 PUFA on endothelium were investigated with the following parameters: the morphological appearance and arrangement of endothelium stained by Ag, in vitro endothelium-dependentrelaxation of aortic ring, endothelial permeability test using Even′s Blue, blood lipid and body weight in one-week intervals, excitative and emissive spectrum of RBC membrane labeled by DPH (1, 6-Diphenyl-1, 3, 5-hexatriene), fluidity of RBC membrane, plasma and RBC membrane LPO

在整体和离体水平，选用大鼠高脂血症模型模拟动脉粥样硬化早期状况。用114只大鼠多指标着重研究n-3多不饱和脂肪酸在高脂血症状态下对内皮的保护作用，以探讨其预防动脉粥样硬化的机理。所采用指标包括：浸银法观察内皮细胞排列与形态；离体血管环观察内皮依赖性舒张；伊文氏蓝染料法观察内皮通透性。为探讨作用机理，进行了血脂和体重的动态监测、DPH(1，6-二苯基-1，3，5，乙三烯)标记红细胞膜的荧光光谱测定、红细胞膜流动性测定、血浆和红细胞膜脂质过氧化物测定。

The molecule mechanism of anti-atherosclerosis is related with the channel of regulating PPARγ. As a new and higher specificity PPARγ excitomotory, Maixinkang is anticipated to supply more effective treatments for anti-atherosclerosis and lipid anomal-metabolism.

其抗动脉粥样硬化作用的分子机制与过氧化体增殖物激活型受体γ调控途径有关，有望成为中医药领域中新的、特异性较高的过氧化体增殖物激活型受体γ激动剂，为抗动脉粥样硬化和脂代谢异常提供更佳的药物选择。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。