动粒

Our analysis indicates that CENP-T/CENP-W and CENP-C provide distinct pathways to connect the centromere with outer kinetochore assembly.

研究表明，CENP-T/CENP-W和CENP-C为着丝粒与外部的动粒形成，提供了不同的连接途径。

In mitosis, a Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerization and converts Mad2 to a conformer amenable to Cdc20 binding, thereby facilitating checkpoint activation.

在减数分裂中，Mad1-Mad2核心复合物通过Mad2二聚化募集胞质Mad2至动粒，并转变Mad2成为能被Cdc20结合的形态，因此促进检验点的活化。

Euglena and Oxyhrris showed two bands, one identical to the Tetrahymena band, another being about -45kD.

进化到了纤毛虫类，着丝粒和动粒蛋白的组份的发展就已经比较完善了。

These findings provide insights into the evolution of meiosis and kinetochore regulation during mitosis and meiosis.

这些发现为研究减数分裂以及有丝分裂和减数分裂中动粒调节的演变提供了基础。

Hecl localizes to kinetochore in cell mitosis, and it is the critical protein for M phase progression.

Hecl定位于动粒，是纺锤体检验点调控的关键蛋白之一，它通过螺旋-螺旋结构域与其他动粒蛋白相互作用调节姐妹染色体的精确分离。

High expression of FAT10 can decrease the molecules positioning on the kinetochore MAD2 and then increase chromosomal instability in the early and mid-term cell cycle.

在细胞周期的前期和中期中，高表达FAT10减少定位在动粒上的MAD2分子，从而增加染色体的不稳定性。

Mitosin is a phosphoprotein implicated in mammalian chromosome segregation mainly due to its dynamic localization at the kinetochores and spindle poles during mitosis.

Mitosin是一个在有丝分裂期被磷酸化的蛋白质，它在有丝分裂期定位在动粒和纺锤体的极点上。

To define the mechanism underlying this mitotic defect, we generated cells that differ only in their centrosome number.

相反，额外中心体癌细胞仅仅是经过一个过渡性的多极纺锤体阶段，在这个阶段，&异常动粒微管附着体&会积累。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。