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OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数,优化给药方案,设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式,CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发,在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物,适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上,结合病人个体特征,以1,2个血药浓度作为反馈,即可拟合估算个体药动学参数,优化给药方案结论经初步应用,CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

Some key part is ameliorated to meet the demands of working. This thesis mainly includes:(1) Analysing the working principle of the spring operateing mechanism, expatiating the character of the mechanism;(2) With the design aim of the spring operating mechanism, accomplishing the design of ZW□-12/630-20 outdoor HV vacuum breaker based on the systemic design theory of the spring operating mechanism, which includes spring mechanism of open-close switch; cam mechanism based on the principle of power balance; buckle-off mechanism with force-minished device; ratchet wheel mechanism with number-increased detent;(3) In the design on the spring operating mechanism for the outdoor vacuum breaker, using the air cushion device with speed controller to ensure the steady working of the spring operating mechanism;(4) Accoding the problem of daily maintenance for HV circuitbreaker, giving some effective steps of daily maintenance.

论文工作主要包括以下几个方面:(1)从真空断路器弹簧操动机构的功能原理出发,详细分析了该机构的工作原理,阐述了机构工作的基本特性;(2)根据工程实际提出了真空断路器弹簧操动机构的设计目标,在系统分析弹簧操动机构设计理论的基础上,完成了ZW□-12/630-20型户外真空断路器弹簧操动机构的设计工作,其中包括真空断路器弹簧操动机构的分合闸弹簧机构的设计;以输出力特性曲线设计机构理论演化出的功率平衡原则为基础的凸轮机构的设计;带有减力机构的滚动摩擦扣结方式的脱扣机构设计;根据实际情况增加了棘爪数量的棘轮机构设计;(3)在真空断路器弹簧操动机构的设计中,引入了速度控制模式空气缓冲器,对惯性负载起到了良好的自动缓冲效果,从而保证了真空断路器弹簧操动机构稳定、有效地运行,保证了真空断路器的动作质量;(4)针对目前真空断路器运行过程中存在的问题,提出了有效的日常维护措施。

Abstract]This paper studies the animation industry by exploring European animation festivals panoramically from the perspective of aesthetic economy and space economy. It is found that semiotic products with great semiotic meaning are not a kind of transcendental presentation but daily reality in the aesthetic economy and space economy era. The animation industry, which is focused on cultural and creative content producing, is a rising industry in which the animation festival is not only the exhibition of traditional commodities but also a creative arena of meaning produce. The restructuring of place for European animation festivals is followed the basic requirement of aesthetic economy and space economy, since the festivals add new semiotic meaning and cultural elements to the original places.

从审美经济、空间经济的视角,以动漫节为研究对象,对欧洲动漫产业发展所形成的文化与市场景观进行一种全景式的考察后,可以发现:在审美经济的时代,以符号意义为主的符号产品不再是超验的表象,而是日常生活的实在;以文化创意内容为核心的动漫产业已经成为新兴产业;其中,作为符号生产与传统商品集中展示的动漫节,更侧重于深入开发动漫及其衍生产品的审美价值,使动漫节不仅仅流于纯粹的小商品集市,而在于创造更多的符号意义,丰富动漫节的多种内涵;动漫节举办地的地点重构适应了空间经济发展的内在要求,动漫赋予不少城镇以全新的符号内涵,创造了各种形态的地点神话,从而促进空间经济的城市发展。

Firstly, we summed up the process and results of historical research. And then we classified the action morpheme and the noun morpheme. Based on the classification, we analyzed noun morphemes in order to find which kind of noun morpheme is strong to unite and which is the weak ones to centre around the action morpheme. Then we stated, analyzed and accounted for the usage of different semantic categories used in the line situation. We found that action morpheme combined into one by moving the line word was the main line and the main format, and explored and analyzed the role of analogy of noun morpheme line to other formats. Line formation of the word has its own reasons, so the article concluded by examining the formation of the line words' language, social and other reasons at last.

文章着眼于对动、名语素组合成的离合词的语义构成进行分析,探讨了动、名语素组合成离合词的语义选择规律,以动、名语素的语义分类为基点,在分类的基础上,以动语素为中心,分析围绕动语素的名语素义类,分析哪些义类名语素和动语素组合成离合词的能产性较强,即组合的周遍性和数量频度上是最高的,哪些义类组合成离合词的能产性比较弱,试图寻找动语素与名语素组合成离合词在义类上的能产性和周遍性,然后再对不同语义类组合中离合运用的情况进行统计、分析、说明。

You can also try to open a little more features, such as animation around, young people are loyal consumer groups, small investment, quick recovery, but also the twenty-first century, pioneering the development of key state industries, like the well-known brand AA Anime International Anime is not only novel and practical The animation peripheral products, as well as creative DIY fashion personality animation production, animation COS pictorial photography and fine animation clothing props, these are precisely the most popular among the young and the pursuit of things.

还可以尝试开个比较特色一点的,比如动漫周边,年轻人是忠实的消费群体,投资小回收快,也是二十一世纪国家重点倡导发展行业,像知名动漫品牌AA国际动漫,不仅有新奇实用的动漫周边产品,还有时尚个性的动漫DIY创意制作,动漫COS摄影写真和精美的动漫服装道具,这些正是现在年轻人最青睐和追求的东西。

Recommendation of the internal representation of the brand-AA Anime International Anime, covering novel animation peripheral products, personalized DIY creative animation production, COSPLAY pictorial photography and fine animation clothing props, compared with other animation is only a single store selling products more professional, China's first four stores in-one diversified interactive operation, very popular with investors and consumers of all ages.

推荐下国内代表性动漫品牌-AA国际动漫,涵盖新奇的动漫周边产品、个性动漫DIY创意制作、COSPLAY摄影写真和精美的动漫服装道具,相比其他动漫店只单一的销售产品更具专业性,国内首创的四店合一多元化互动式经营,非常受投资者和消费者的青睐。

The main agent of the Company's brand power has Germany Atlas family of products; the United States DEWALT electric products; Taiwan Black steam-driven tools, steam-driven tools OP Taiwan, Taiwan AIRBOSS steam-driven tools, such as steam-driven products; American Danaher "Cedel" hand tools series products; Japan Maeda (Japan dragged Nigeria hand tools); LD Screw Machine Products; Kaishan screw machine, firewood motivation products; HL Welding equipment product line; Matsushita Welding equipment Products ; Golden Elephant grinding wood products; Japanese fan license granted Tsui products.

本公司主要代理的品牌有德国Atlas电动系列产品;美国得伟电动系列产品;台湾黑牛汽动工具、台湾OP汽动工具、台湾亚柏士汽动工具等汽动系列产品;美国丹纳赫&世达&手工具系列产品;日本前田;LD螺杆机系列产品;开山螺杆机、柴动机系列产品;HL焊割设备系列产品;日本松下焊割设备系列产品;金象研磨材系列产品;日本扇牌批咀系列产品。

Driving experiments were conducted to investigate drivers' eye movements at the expressway tunnels. With a consideration of the average fixation time, the fixation proportion, the fixation duration, the fixation frequency and the visual lobe, a new eye movement index based on plane distribution of viewpoint was proposed to evaluate the driver's visual information processing level.

以高速公路隧道路段驾驶员视点变动为研究对象,在传统的平均注视时间动视点指标、注视时间比率动视点指标基础上,根据大量动视点行车实验,考虑驾驶员注视时间、注视频率、视力角等眼动特征,提出了基于视点平面分布的动视点指标,以评价驾驶员视觉信息加工水平。

2Theory of pulse combustion was analyzed and its mechanism were discussed with planewave transferring theory in the thesis.Models of pulse combustor were reviewed and analyzed.Theone-dimensional unsteady nonlinear model of pulse combustor was simplified with lineal method.The phase relation between pulse pressure and combustion heat discharge which may prompt ordamp pulse combustion process were discussed.

对脉动燃烧理论进行了分析探讨,从平面波的传递理论出发,分析了脉动燃烧的机理;在归纳综合现有的脉动燃烧器理论模型的基础上,采用线性化分析方法,对一维非线性脉动燃烧器理论模型进行了简化,并定性分析了脉动压力与燃烧放热之间的相位关系对脉动燃烧过程的激励和阻尼作用。

In view of a large number of data for dynamic pile test s and theory of onedimensional wave action and wavelet effect,a flow chart of analytical waveshape is drawed up.

通过大量动测桩资料,依据一维杆波动理论与子波效应理论,绘制了动测桩波形分析流程图,建立了桩身缺陷与动测波形特征之间的关系,给动测桩身完整性提供了参考判据。

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化,但却比去年同期高8%。

However, to get a true quote, you will need to provide detailed personal and financial information.

然而,要让一个真正的引用,你需要提供详细的个人和财务信息。