动物实验的

So it is veryimportant and exigency to find a new development mode of laboratory animal science in China.

因此，研究实验动物科学发展规律，提出我国实验动物科学发展的新模式具有重要意义。

Methods: iEstablishing the animal model of HSP :Gliadin being taken as food antigen,meanwhile reticuloendothelial system being blocked by India ink,these two methods were applied to make mouse under the condition of clearance deficiency in reticuloendthelial system...

1。建立过敏性紫癜实验动物模型：以麦胶蛋白作为饮食抗原，加用印度墨水封闭网状内皮系统的动物造模方法，使模型小鼠在网状内皮系统清除功能缺陷的前提下，持续抗原刺激粘膜免疫系统，建立HSP实验动物模型。

In order to inquire the causes of occurrence of lipoid pneumonia in rat that were raised in standard SPF animal reproductive area, we used self-reproducing standard SPF rats, male 50 and female 50. All of the rats were divided into 10 groups, raised in standard Barrier system, and fed the standard diets imported from U.S.A.. All animals were divided into 4 stages to sacrifice. Autopsy, histopathological and blood biochemical examination were made at each stage. The results reveal that no lipoid pneumonia were found to occur in the 5, 10 and 26-week-old groups of male and female rats. 40% of male and 60% of female were found to occur slight focal lipoid pneumonia in the 52-week-old groups of rats.

利用成大医学院实验动物中心生产的标准无特定病原大白鼠雌、雄各50只分成10组，在屏障系统中进行实验，使用美国进口的标准实验动物饲料餵食，在一年中分四期剖检，并做病理组织学及血液生化学观察，分析比较结果显示5，10及26周龄的雌、雄大鼠皆未发生类脂质性肺炎。52周龄雌大鼠有60%，雄大鼠有40%观察到患有轻度局部性类脂质性肺炎。

A series of indexes reflecting free radical changes, anti-oxidations, Immune function, endocrine function was studied by Chemiluminescence method, immunoturbidimetry, ANAE dye method, micro-hemagglutination inhibition test and radio immunoassay in the chicken with encephalomalicia induced by giving the feed being deficient in VE and extra fish oil artificially. The pathological changes including microscopic and ultramicroscopic changes in the relative organs and tissues were observed.

本实验以一日龄150只海兰兰蛋鸡为实验动物，用低维生素E且添加鱼油日粮饲喂雏鸡，复制脑软化症动物模型，采用化学发光法、免疫浊度测定法、酸性α-醋酸萘脂酶染色法、微量血凝抑制试验、放射免疫测定技术等方法系统地检测了脑软化雏鸡的自由基代谢和抗氧化功能、红细胞免疫功能、细胞免疫功能、体液免疫功能及非特异性免疫功能等指标，并对患雏病理组织进行了显微及超微结构观察。

Objectivc To observe spontaneous pathologic change in main organs of conventional and specific pathogen free rats, to provide necessary and important base of raising environment affecting autopathy in test animels, and to get the message of the statue of autopathy in current laboratories, to provide spontaneous pathologic change type and incidence of it for pathologic diagnosis in SPF rats.

目的观察普通级及SPF级正常大鼠主要脏器病理切片，为实验动物饲养环境对动物自身疾病的影响提供重要依据，同时了解目前实验室内动物自发病状况，为病理诊断提供SPF级饲养大鼠自发病组织学改变类型及发生率。

The model had good duplicability and stability through the method of establishing the animal model in which the simple operative method,small wound and convenient nurse was obtained so easilyis that the animal model was spread easily.The study of the change of short and long period was made to provide the experimental base and reason through the animal model.

结论通过自制冲击器冲击兔右侧髋臼软骨，模拟冲击伤机制，初步建立髋臼软骨冲击伤实验动物模型并量化冲击能，通过统计学分析，大体和组织病理学检查，并与国外动物模型相比，本模型重复性和稳定性好，术式操作简单，创伤小，护理方便，易于推广，为研究活体动物髋臼软骨冲击后的短期和长期变化提供实验基础和依据。

New Zealand white rabbits (3-4 months old, 3-4 kg weight) were the test animals, and they were divided into three groups proceeding in this study. In group A:One PLLA screw and one commercial screw were implanted in the right tibia. Two PLLA screws were implanted in the left. Furthermore, one PLLA bar was implanted in both right and left tibia respectively with onlay model in group B. Also,one PLLA plate was implanted in the left tibia and one commercial plate in the right respectively with onlay model in group C . Many tests were done on each sample in 1, 4, 8 and 12 weeks which included the observation of tissue response in group A, and the change of three-points bending, weight loss, molecular weight, crystallinity and morphology of fracture surface by scanning electronic microscopyin group B, and the change of three-points bending, weight loss and molecular weight in group C.

所使用实验动物为24只3-4个月大，体重3-4公斤的纽西兰兔，并将所使用材料及动物分为A、B、C三组进行。A组中於实验兔之右胫骨植入两支骨钉，一支为自制骨钉，一支为MacroPore市售骨钉，并钻一孔但不植入骨钉做为控制组；另於实验兔之左胫骨植入两支自制骨钉，另标示一区不钻孔不植入骨钉做为控制组。B组采用onlay1 模式於实验兔之左右胫骨各植入一自制长型片。C组也采用onlay模式於实验兔之左胫骨植入一自制骨板，於右胫骨植入一市售骨板，各於不同时间点( 1， 4及12周)将A及C组，而於( 1，4，8及12周)将B组内的植入物取出进行各种测试，包括A组的组织切片观察及B组的三点弯曲变化、质量损失、分子量变化、结晶度变化及扫描式电子显微镜观察断面型态改变及C组的三点弯曲变化、质量损失、分子量变化。

To promote a test zoologic of course of this one foundation deepen and the system develops, highlight course characteristic, hold experimental animal to study horizontal forward position, decide definitely below the times setting that accords with existing course development, ask to fall in the consistent proposal of wide readership and author, in April 2006 classics country news publishs total arrange to approve, rise from January 2007 " experimental animal science and management " will formal more the name is " experimental animal science ".

为推动实验动物学这一基础学科的深化和系统发展，突出学科特征，把握实验动物探究水平前沿，在符合现有学科发展的时代背景下准确定位，在广大读者和作者的一致建议要求下，于2006年4月经国家新闻出版总署批准，自2007年1月起《实验动物科学和管理》将正式更名为《实验动物科学》。

Strict sterilization measures shall be taken for areas inside and outside the feeding and breeding room and the case shall be reported to the higher authority for the administration of experimental animals and to the local animal quarantine and epidemic prevention unit so that emergency preventive measures shall be taken to prevent the spread of the disease.

对可能被传染的实验动物，进行紧急预防接种，对饲育室内外可能被污染的区域采取严格消毒措施，并报告上级实验动物管理部门和当地动物检疫、卫生防疫单位，采取紧急预防措施，防止疫病蔓延。

Materials And Methods 1, The animal model of Sprague-Dawley rat for maxillary protraction was made in this study, and an appliance based on the principle of protraction headgear was designed and made for maxillary protraction treatment which was hooked over the front of the zygomatic arch ,and a hole was made on the skull in the experimental group rat .

以面具式前牵引矫治器为原理制作特殊的前牵引支架，以外科方法安装支架挂在大鼠颧弓前端，在实验加力组大鼠头颅上打孔，安放挂钩，通过弹性牵引提供支架向前牵引的支抗。2、以该动物模型为基础，选用90只五周龄的Sprague—Dawley健康雌性大鼠作实验动物，随机分到实验加力组、正常对照组、手术对照组。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。