动学

According to the published antimode of AUC distribution, 22.5 ngh/ml/mg, which proposed by Kleinbloesem, there are 69.3% subjects belong to slow metabolizer in Taiwan residents.

而与白种人比较起来，NF於台湾族群之药动学在AUC方面与白种人有显著不同，显示台湾族群对於NF之代谢有比白种人低的可能性。

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

Results: The pharmacokinetics of high dose epirubicin was best described by a typical three-compartment model. It showed wide interindividual variation.There was no correlation between its pharmacokinetics and pharmacodynamics. Age was negatively correlated with epirubicin clearance.

结果：高剂量EPI的消除具有典型的三室特征，患者对EPI的代谢存在较大的个体差异；药效学和药动学参数之间未见到明显相关性，年龄与血浆清除率之间呈负相关。

Methods: the rats were intragastric administered with compound recipe and extractive of longspur epimedium respectively. the blood concentration of different time points were tested by proposed established rp-hplc. data were dealed with pharmacokinetic programme, and fitted to kinetic parameter.

实验大鼠分别灌胃复方及单味药材提取物后，测定不同时间点血浆中淫羊藿苷的浓度，采用药动学程序3p97对数据进行统计学处理，进行药动学模型拟合并计算相关药代动力学参数。

Restrain thrombocyte to release 5-HT and prevent Ca channel 'of thrombocyte experimen are chosen to carry out the pharmacodynamics research. Also analysis the PK-PD model.

选择抑制血小板释放5-HT实验和阻滞血小板钙通道实验进行了药效动力学研究，并进行了药动学药效学相关性分析。

HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits,then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema.

采用高效液相色谱法测定黄芩苷和绿原酸在家兔体内的血药浓度，采用药动学程序3P97进行统计处理，确定药动学模型及相关药代动力学参数。

Methods The plasma concentration of epigoitrin after ig administration with total alkaloids of Radix Isatidis was determined by HPLC method and the body temperature was recorded by electronic thermometer. The individual PK parameters were fitted using one compartmental model.

给大鼠ig板蓝根总生物碱，不同时间取血并对体温进行观察，采用高效液相法测定血浆中表告依春的浓度，用一房室模型计算药动学参数，采用3种药动学与药效学拟合模型，分别对药效学参数进行拟合。

Then, pH-dependent behavior in both microspecies distribution and molecular electrical charge was described in detail.

其中运用药动学理论来定量描述和解析两抗菌药在大鼠体内两部位分布的动态学行为；使用体外培养的肺泡巨噬细胞单层模型，在依据其理化特性参数的基础上，来解释肺泡巨噬细胞对两抗菌药的吸收机理；并且得到以下初步结论

The pharmacodynamic and pharmacokinetic profiles , clinical efficacy and adverse reactions of caspofungin are reviewed in this paper.

本文综述了caspofungin的药效学、药动学特性、临床疗效和不良反应等。

This review outlines the pharmacodynamic and pharmacokinetic profiles of voriconazole and focuses on clinical applications and safety profile.

本文综述了伏立康唑的药效学、药动学特性及临床应用等研究进展。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。