加重

The leptin can be an inflaming mark of the acute exacerbation phase in chronic obstructive pulmonary disease patients with COPD.

COPD患者急性加重期leptin明显升高，可作为急性加重期的炎性标记物。

Objective To study the changes of t-PA and t-PA inhibitorduring the acute stage of cor pulmonale.Methods To measure the plasmatic activity of t-PA and PAI by chrom-substrate in60cases of cor pulmonale,compared with the corresponding index of55cases in the control group.

目的 探讨血浆组织型纤溶酶原激活物及t-PA抑制物在肺心病急性加重期的变化方法用发色底物法测定60例肺心病急性加重期的血浆t-PA及PAI的活性，并与对照组55例肺心病缓解期的相应指标作比较。

Results Supraorbital neuralgia (9.8%) and superficial temporal neuralgia (3%) occurred 3~4 days and aggravated 4~7 days after subfrontal craniotomy. The headache could be persistent and become more serious intermittently and irrsdiated to frontal, parietal, temperal, and para-orbital region.

结果 眶上神经痛和颞浅神经痛均出现于冠状切口经额下入路术后第3~4天，第4~7天逐渐加重达到高峰，均为中、重度疼痛，呈持续性伴阵发性加重，向同侧额部、顶部、颞部或眶周放散，眶上切迹或颞浅动脉处压痛明显。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

PaO2/FiO2 of both patients was less than 225 mm Hg.In both patients, high-resolution computed tomography scans at the exacerbation showed typical signs of IPF including peripheral predominant, basal predominant reticular abnormality, with honeycombing and traction bronchiectasis and bronchiolectasis,and newly developing alveolar opacity.

呼吸困难分别在1周和半月内加重；2例患者氧合指数均小于225 mm Hg；急性加重时2例患者HRCT表现为两下肺分布的网状影、蜂窝影、牵拉性细支气管扩张和支气管扩张等典型的IPF表现，并出现新的磨玻璃影。

The results indicated that all the 10 genes except Mads and Grp greatly increased with increasing intensity of drought stress in silks. In ears, 9 of 10 genes significantly increased with increasing intensity of drought stress except Mads.

结果表明，在花丝中，除基因Mads和Grp外，其他8个基因均随干旱胁迫程度加重，相对表达强度增加；在幼穗中，除基因Mads外，其他9个基因均随干旱胁迫程度加重，相对表达强度增加。

Pleaded guilty to occasioning the death of his passenger while driving under the influence of intoxicating liquor, against the Crimes

以此观之，胡斌案是有加重情节的，也就是说这些加重情节是要影响量刑的。

And he spoke according to the advice of the young men : My father laid upon you a heavy yoke, which I will make heavier: my father beat you with scourges, but I will beat you with scorpions.

依照少年人的主张答复人民说：「我的父亲加重了你们的重担，我更要加重；我父亲用鞭子责打你们，我要用铁刺鞭责打你们。

And he spoke according to the advice of the young men : My father laid upon you a heavy yoke, which I will make heavier: my father beat you with scourges, but I will beat you with scorpions.

依照少年人的主张答覆人民说：「我的父亲加重了你们的重担，我更要加重；我父亲用鞭子责打你们，我要用铁刺鞭责打你们。

3The abnormal degree of sublingual venae in lung cancer patients are higher than the normal person,and sublingual venae are often green purple, purple black. With the deterioration of the disease, the degree of abnormality and darker color gradually increase.

3肺癌患者舌下络脉的异常程度高于健康人，颜色以青紫色、紫黑色为主；随着病情的加重其异常程度逐渐加重，颜色加深、加暗。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。