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The reported organocatalyst for asymmetric Michael additions include proline and its derivatives, chiral imidazolidinone derivatives, chiral urea, cinchona alkaloids and so on.

目前报道的催化Michael加成反应的有机催化剂主要有脯氨酸及其衍生物、手性咪唑啉酮、手性脲、金鸡纳碱衍生物等。

Results The linear correlation coefficient of standard curve of hydroxyproline was 0.9998, the recovery rate of standard addition was 85.8%~91.0%, and the relative standard deviation was 2.27%.

结果 经脯氨酸标准曲线的线性相关系数r=0.9998,加标回收率在85.9%-91.0%之间,相对标准偏差为2.27%。

Methods 120 patients with chronic heart failure were randomly divided into two groups. Patients in both groups were treated with digitalis, diuretic and angiotensin-converting enzyme inhibitor and patients in treatment group received additional amlodipine.

采用随机对照的方法,将120例慢性心功能不全患者随机分为治疗组和对照组,对照组以洋地黄、利尿剂及血管紧张素转换酶抑制剂等药物治疗,治疗组在对照组治疗基础上加用氨氯地平片(5~10)mg/d。

Methods Sixty RA patients were randomized into two groups:the control group(n=30)received meloxican and methotrexate,and the treatment one(n=30)received herbal fumigation and steaming of Xunzheng Prescription(mainly composed of Cangzhu,Gentiana,sea breeze rattan,Motherwort,Lycopodium japanicum grass,grass reinforcement Granville,Clematis,Glycyrrhiza,Tripterygium wilfordii,papaya,raw Kusnezoffii,Strychni)additionally.

将60例类风湿关节炎患者随机分为治疗组和对照组,对照组(n=30)给予洛索洛芬钠片和甲氨蝶呤片治疗,治疗组(n=30)在对照组治疗基础上加用中药熏蒸处方(苍术、秦艽、海风藤、益母草、伸筋草、威筋草、威灵仙、甘草、雷公藤、木瓜、生草乌、马钱子)治疗,10天为一疗程。

Methods:90patients were randomly divided in to 3groups.Group A was with puerarin.pur injection,Group B wit h puerarin.pur injection plus potass ium magnesium aspartate,Group C with ordinary dosage of digax in.

方法将CHF患者90例随机分为A、B、C三组,均以血管紧张素转换酶抑制剂、倍他乐克及利尿剂作为基础治疗,A组加葛根素注射液静滴,B组予葛根素注射液及门冬氨酸钾镁静滴,C组予地高辛口服。

During these years (1997-2000) in the research area of annonaceous acetogenins 5 natural products and a number of chiral-pure analogs of annonaceous acetogenins have been synthesized using sugars as the starting materials. Their high activity and selectivity against cell line of colon tumor and a relationship between activity and configuration have been found too. In the respect of inhibitor of sialidase two new methodologies for the synthesis of chiral-pure 3-deoxy-ulosonic acid using hetero-Diels-Alder reaction or asymmetric propargylation as the key reaction were developed. On the topic of anti-leukemia marine natural product clavulactone a synthetic method based on the free radical cyclization and starting from sugar has been developed. In other title of PKC inhibited agent sphingosine a new synthetic route with SN2' as the key reaction has also been disclosed.

项目期间(1997-2000)在番荔枝内酯方面从糖出发合成了五个天然产物和一批手性纯的类似物,它们对肠癌细胞有很高的活性和选择性,并与构型有关;在唾液酸酶抑制剂方面发展了二类全新手性纯高碳糖的合成方法-杂原子D-A反应或丙炔基不对称加成为关键的反应;抗白血病海洋天然产物群柱虫内酯方面研究了由糖出发和自由基环化反应的合成方法;对PKC 起抑制作用的鞘氨醇方面也开创了新的合成途径-由糖出发并以SN2'反应为关键反应。

Four new chiral sulfonamide alcohol s were synthesized from camphor and L-phenylalanine and their application to the enantioselective addition of diethylzinc to benzaldehyde was described.

由天然樟脑和-苯丙氨酸合成了4个新的手性磺酰胺醇,并对其在二乙基锌对苯甲醛的不对称加成中的催化性能进行了研究。

Four new chiral sulfonamide alcohols were synthesized from camphor and L-phenylalanine and their application to the enantioselective addition of diethylzinc to benzaldehyde was described.

由天然樟脑和-苯丙氨酸合成了4个新的手性磺酰胺醇,并对其在二乙基锌对苯甲醛的不对称加成中的催化性能进行了研究。

If seizures supervene, the treatments of choice are benzodiazepines, gabapentin, and vigabatrin.

急性卟啉病发作时,如果出现痫性发作;可以选用苯二氮卓类药物、加巴喷丁、氨己烯酸等药物控制发作。

Those indices such as AOPPs, protein thiol groups and dityrosine were used as biomarkers of protein injury.

对照组内不加任何尿毒素。37℃分别温育0.5 h和24 h后,分别测定各组的AOPPs、蛋白巯基及二酪氨酸浓度。

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