加大

Objective: To determine the safety, tolerability, and pharmacokinetics of increasing doses of idebenone in subjects with FA.

目的：测定FA患者中艾地苯醌加大剂量使用时的安全性，耐受性和药代动力学。

According to the H NMRstudy, it was found that the protons on the cyclopentadienyl ring of 〓 were not splitted, but when one proton on the cyclopentadienylring was substituted by methyl, that is in〓 complexes, thefour protons on the ring were splitted into four groups,the 〓 between the onesignal and the others is large, the total splitting is over 2ppm. The splittings werealso affected by the halides linked with the titanium, they increase according to theorder of CI, Br, I. By the study of the 〓 Sn NMR, it is found that the chemicalshifts of 〓 are present in low field. It is assume that the large space strain causesthe angles of the tin linked with ligands deviate from the normal tetrahedral anglesresults low field shift for 〓Sn. And by MS study,there were no molecular ions for 〓 complexes in the spectra. However, for 〓 when X=CI,Br,NCO and Ar is tolyl or phenyl group,there were molecular ions,but theirabundances were very small,and no that for the iodide was found.

钛上的卤素对茂环氢的裂分也有影响，依〓，Br，I顺序，卤素对茂环氢的裂分依次加大；通过对〓的研究发现，以上这些化合物〓的化学位移都出现在低场，认为大的空间张力造成的锡的键角偏离正常的锡的四面体键角是造成〓化学位移出现在低场的原因；对这些化合物质谱的研究发现，〓系列化合物得不到分子离子峰，而〓系列的化合物，当X=〓，NCO和苯环上不带取代基或只带甲基时，则出现分子离子峰，但丰度很低，而相应的碘化物和其它化合物则没出现分子离子峰。

When he shot Tootsie, he also showed Hollywood that a short man with a big nose could be a great leading lady.

在《宝贝儿》一片中，他又向好莱坞证明了小个子加大鼻子还能是一位时髦的女士。

On the other hand, this kind of company stock price is in the top digit to lack the substantive essential factor to prop up, so it is easy to form the foam.

另一方面，此类公司股价处于高位而缺乏实质性要素支撑，易形成泡沫，加大市场风险，危害证券市场的稳定和发展。

Simultaneously the enterprise enlarges unceasingly to studies the development the investment, every year invests the massive funds to use in the new product the development, causes enterprise's development momentum maintains the top digit throughout, every year always has several new products to be published, what walks is precisely the science and technology is popular road of the factory.

同时企业不断加大对研究开发的投入，每年投入大量的资金用于新产品的开发，使企业的发展态势始终保持高位，每年总有几个新品问世，走的正是科技兴厂之路。

For one thing, if the materials store is too large, it will occupy too much fund and lead to torpidity of turnover fund. On the other hand, if the materials store is too small, it cannot meet the requirement of selling and producing, and will certainly increase purchase frequency or produce batch, thus this will expand the cost of purchase and produce, and cause the sum cost of inventory to be large. Therefore, enhancing the ability of inventory management and service level for its customers, and reducing the storage and the inventory cost is an important target of enterprise inventory management.

一方面，如库存量过大，则占用资金量过多，易于造成流动资金周转不灵；另一方面，若库存量过少，不能满足生产、销售的实际需要，势必要增加采购次数或生产批次，这样就加大了采购或生产成本，造成总库存成本过大，因而不断提高库存管理水平和客户服务水平、尽量降低库存水平、减少库存成本就成了企业库存优化的目标。

And less than a month's time, once again out of the New Deal efforts to increase trade-in.

而不到1个月时间，再次出新政加大以旧换新力度。

Actually, we will have difficulty in upgrading and transplanting.

这无疑加大了移植及设备升级的难度。

As the carrier to the environment, create a school environment 2005, the government and the Ministry of Education to increase investment and further improve the bridge secondary conditions, the original bridge Fengxian secondary schools as we build a new school, but now the whole school look, tree-shaded lawn as carpet.

以环境建设为载体，营造学校环境 2005年，区政府、教育局加大投资力度，进一步改善南桥中学办学条件，原奉贤中学作为我们南桥中学的新校址，如今，学校整体面貌焕然一新，绿树成荫，草坪如毯。

Barry, in "Tradition of Scripture"(New York, 1906), 102, says:"It is plausible to maintain that inscriptions to which the Massorah, LXX, and Vulgate bear witness cannot be rejected. But to look on them, under all circumstances, as portions of Scripture would be to strain the Tridentine Decrees".

巴里，在"传统经文"（纽约， 1906 ）， 102 ，说："这是似是而非保持题字，这massorah ， lxx ，和武加大见证不能予以拒绝，但看对他们，根据所有情况下，由于部分经文，将是紧张，德律但丁的法令"。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。