功能失调的

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin Ⅱ and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明：(1)在心力衰竭状态下压力感受性反射功能明显减弱；(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用；(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射；(4)适当的运动可以部分纠正异常的心血管反射活动。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明：(1)在心力衰状态下压力感受性反射功能明显减弱(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用；(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射；(4)适当的运动可以部分纠正异常的心血管反射活动。

On one hand, every organ, tissue and even cell of the body participates in and affects the state of serum lipoprotein dynamic balance in different degrees. On the other hand, SLDB is a direct factor for maintaining the normality of whole vascular system, especially the vascular endothelium system. The serum lipoprotein dynamic imbalance, as an inducement or even etiological factor, can bring about various clinical diseases. Therefore, integrated analysis is needed to appropriately assess the state of SLDB.

一方面，机体的每一器官、组织以至细胞都不同程度地参与并影响著血清脂蛋白动态平衡状态；另一方面，血清脂蛋白动态平衡是全身血管系统功能正常的直接条件，其平衡失调则成为全身血管系统功能异常的诱因，甚至引发临床诸多病证。

High iodide intake may aggravate patient's clinical symptoms such as thyrocele and ophthalmopathy, but there is no relation between level of UI and thyroid function .Improper iodine supplement to AITD patients may strengthen the immune function disorder .The abnormal increase of cytokine IL-1? and expression of CD80、 HLA-DR on PBMC may involve in the mechanism.

高碘可能加重了AITD突眼、甲状腺肿大等症状，但与甲状腺功能状态没有明显关系；本研究还提示对AITD不适当的补碘可能会导致甲状腺局部乃至全身的免疫功能失调，IL-1β等细胞因子和PBMC表达的HLA-DR、CD80异常与高碘导致的免疫紊乱可能有一定关系，值得进一步探讨。

Fong: professor ZhangYan mentor can be traced the etiology of chronic heart failure in anxiety, long qi Yin and Yang is damaged, viscera function disorder, veins stagnant water passes, in: After the attacks, the modern sense, intradermic injury, overwork, pregnancy and birth or aggravated induced disease.

导师张艳教授认为慢性心衰的病因可溯源于心病久延，气血阴阳受损，脏腑功能失调，血脉通行受阻，水湿瘀血内停所致；复感外邪，情志内伤，劳累过度，妊娠分娩等均可诱发或加重本病。

In addition , sometimes uterine flesh tumour accompanies ovarian function maladjusted , also may be one of infecund reasons .

此外，有时子宫肌瘤伴随卵巢功能失调，也可能是不孕的原因之一。

When the function of the human bowels is misadjusted, the reflection section of the thenar can eliminate the blocks of the circulation of blood and breath, and adjust the normal physical activities of human body.

可以间接或直接的反映人体脏腑的功能，当人体脏腑功能失调时，在足部的反射区，可以消除气血运行的障碍，从而调节人体正常的生理活动。

In this study, we therefore hypothesized that changes in intrapelvic neurokinin system and DOR detrimental to renal sensory response in nephropathies and HPC may affect above molecules to prevent the loss of ARNA response.

因此，我们假设快肽、神经激肽受体以及DOR可能在肾脏疾病所引发的肾感觉功能失调中扮演相当重要的角色；并且低氧预处理可能透过这些因子来达到其感觉功能的保护效果。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐