功能失调

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin Ⅱ and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明：(1)在心力衰竭状态下压力感受性反射功能明显减弱；(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用；(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射；(4)适当的运动可以部分纠正异常的心血管反射活动。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明：(1)在心力衰状态下压力感受性反射功能明显减弱(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用；(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射；(4)适当的运动可以部分纠正异常的心血管反射活动。

High iodide intake may aggravate patient's clinical symptoms such as thyrocele and ophthalmopathy, but there is no relation between level of UI and thyroid function .Improper iodine supplement to AITD patients may strengthen the immune function disorder .The abnormal increase of cytokine IL-1? and expression of CD80、 HLA-DR on PBMC may involve in the mechanism.

高碘可能加重了AITD突眼、甲状腺肿大等症状，但与甲状腺功能状态没有明显关系；本研究还提示对AITD不适当的补碘可能会导致甲状腺局部乃至全身的免疫功能失调，IL-1β等细胞因子和PBMC表达的HLA-DR、CD80异常与高碘导致的免疫紊乱可能有一定关系，值得进一步探讨。

When the function of the human bowels is misadjusted, the reflection section of the thenar can eliminate the blocks of the circulation of blood and breath, and adjust the normal physical activities of human body.

可以间接或直接的反映人体脏腑的功能，当人体脏腑功能失调时，在足部的反射区，可以消除气血运行的障碍，从而调节人体正常的生理活动。

The endothelium-dependent vasodilation is impaired in patients with hypertension and the high-frequence ultrasound can be used to detect endothelial dysfunction.

高血压患者存在血管内皮依赖性舒张功能失调，高频超声能准确可靠地检测血管内皮依赖性舒张功能。

If the viscera function disorder, whole appears on the imbalance of Yin and Yang,"disease".

如果五脏功能失调，则整体上会出现"阴阳失调"的疾病状态。

Previously we found that ARNA response was impaired in rat nephropathies of puromycin aminonucleoside, lipopolysaccharide, or cyclosporine A, and these sensory defects were ameliorated in rats pretreated with hypoxia preconditioning. However, the underlying mechanisms are not clear.

依据本实验室之前研究，在许多肾病变中，包括：嘌呤霉素核苷酸（puromycin aminonucleoside， PAN）、内毒素（lipopolysaccharide， LPS）、以及环孢菌素A（cyclosporine A， CsA）所引起的肾病变中，都观察到肾脏感觉功能失调的现象，而且本实验室之前的研究也发现低氧预处理能够减缓这些疾病中肾感觉功能失调的现象。

There are many complex factors, such as age, environmental, social, psychological, personal factor and human diseases, etc., affecting the development of insomnia symptoms. Insomnia is one kind of neurology/psychiatry diseases, due to brain overstrains and stresses in the nerve center system, in Western Medicine, while there are approximately two factors that can cause the insomnia symptoms, including the anti-pathogenic- qi deficiency and the pathogenic-factors invasion in Traditional Chinese Medicine.

失眠的原因有年龄、环境、社会心理、身体疾病等繁多复杂因素所造成，西医学认为失眠是由大脑压力所造成脑与神经所支配命令的自律神经系统降低或失去其调整身体功能作用之中枢神经系统失调的疾病症状，然而，中医学的失眠病因病机可概括为正虚、邪扰两种，其中正气虚涉及心、脾、肝、胆、肾、胃等脏腑，邪气扰则以痰、热、火、饮、食为多，失眠的病因主要有脏腑虚损、精血不足、神魂失养、七情所伤、内邪滞扰、外邪所感、思虑劳倦太过或暴受惊恐，亦可因禀赋不足、房劳久病或年迈体虚等所致；失眠的主要病机在於阴阳及气血失和，脏腑功能失调，进而神明被扰、神不安舍所致。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。