前列腺的

The HPFS reported that risk factors associated with an increased risk of CaP mortality were a higher incidence of CaP, an increased likelihood of poor prostate tumor differentiation, a preferential increase in the progression of highly differentiated tumors, or an increase CaP death rate independent of incidence stage at diagnosis or grade.

该hpfs报道说，相关风险因素增加的风险上限，死亡率较高发病率的上限，增加的可能性穷人前列腺肿瘤分化，以优惠的增加，在循序渐进的高度分化的肿瘤，或提高上限死亡率独立的发病率这个阶段，诊断或职系。

We hung about the stadium, we've got no place to stay We hung about the tenderloin and tenderly you tell About the saddest book you ever read that always makes you cry The statue's crying too and well he may I love you I've a drowning grip on your adoring face I love you my responsibility has found a place Beside you and strong warnings in the guise of gentle words Come wave upon me from the family wider net absurd "You'll take care of her, I know it, you will do a better job" Maybe, but not what she deserves Elope with me Miss Private and we'll drink ourselves awake We'll taste the coffee houses and award certificates A privy seal to keep the feel of 1960 style We'll comment on the decor and we'll help the passer by And at dusk when work is over we'll continue the debate In a borrowed bedroom virginal and spare The catcher hits for .318 and catches every day The pitcher puts religion first and rests on holidays He goes into cathedrals and lies prostrate on the floor He knows the drink affects his speed he's praying for a doorway Back into the life he wants and the confession of the bench Life outside the diamond is a wrench I wish that you were here with me to pass the dull weekend I know it wouldn't come to love, my heroine pretend A lady stepping from the songs we love until this day You'd settle for an epitaph like "Walk Away, Renee" The sun upon the roof in winter will draw you out like a flower Meet you at the statue in an hour Meet you at the statue in an hour

我们红约大球场，我们已经准备好没有住宿地点我们红关于tenderloin和温柔，你告诉关于最悲惨的书，你读总是让你哭雕像的哭声太以及他可能我爱你我已经一溺水掌握在您的崇拜面对我爱你，我有责任找到一个地方旁边的你和强烈的警告，假借温柔的话来波后，把我从更广泛的家庭净荒谬"你可以照顾她，我知道它，你会做的更好"也许，但不是什么值得她 elope与我错过私人，我们会喝自己清醒我们将品尝到咖啡的房屋和颁授证书 1枢密院密封，以保持觉得1960年的作风我们会发表评论装潢和我们将帮助途由和黄昏时的工作是超过我们将继续辩论在借来的卧室处女和备件捕手安打为0.318和捕捞的渔获，每一天投手把宗教首先在于对假期他进入大教堂和谎言前列腺在地板上他知道酒后影响他的速度，他的祈祷一大门口回到生活，他希望和认罪的板凳生活以外的钻石是一个扳手我希望你在这里跟我通过平淡的周末我知道它不会来的爱，我的女主人公假装一位加强从我们热爱的歌曲，直到这一天您想要解决为墓志铭一样，"走开，蕾妮"太阳后，屋顶在冬季将以此为你喜欢的花满足你的雕像在一个小时满足你的雕像在一个小时

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

Fat drippings create smoke that is filled with carcinogenic polycyclic aromatic hydrocarbons, or PAHs. When the smoke envelopes the food, it transfers the PAHs onto the surface of the meat. And when meat, chicken and fish are grilled at high temperatures for long periods of time, compounds inside the food react and create heterocyclic amines, or HCAs. HCAs are worrisome because in lab studies they've been shown to trigger breast, colon and prostate tumors in rats and mice.

滴下来的油脂产生的烟雾充满了致癌的多环芳烃，简称PAHs，当烟雾环绕在食物周围的时候，这些多环芳烃也附着在了食物的表面，当猪肉，鸡肉或是鱼肉在长时间的高温烧烤时，这些食物本身所含有的成分产生了化学变化生成杂环胺类物质，简称HCAs，这类物质相当的麻烦，因为实验室研究发现它们会引起大鼠和小鼠乳腺，结肠以及前列腺部位的肿瘤。

Rresults from those studies can be summariazed as follow:(1) A preliminary study no correlationship between the UV-VIS reflection spectrum of tomato fruit surface and the lycopene amount of tomato fruit was undertaken. Based on observation from this study, a damage-free and in-situ detection technique of lycopene amount from tomato was developed with UV-VIS reflection spectroscopy;(2) The geometrical isomers of lycopene were separated successfully on C30-HPLC-PDA-ELSD. The absorption coefficients of Z-isomers were consequently dedermined. The geometrical isomer composition of lycopene could therefore be assessed. Those efforts formed a solid base to identify the natural product from synthetic compound of lycopene;(3) Lycopene resource from the fruit of Autumn oliver was proved to be available for industrial application. An extraction methos of lycopene from the fruit of Autumn oliver by supercritical carbon dioxide was developed at laboratory scale;(4) A method to extract lycopene by supercritical liquid with improved efficiency was developed; Data from this investigation suggested that a proper raw material pre-extraction process was important for a better extraction efficiency;(5) Variation in the geometrical isomer composition of lycopene during its metabolish in rat was assessed. A large amount of Z-isomers were observed. This variation took place in serum;(6) The absorption rate and accumulation in serum of natural lycopene in rat were assessed;(7) Ability to quench singlet oxygen by different geometrical isomers of lycopene was compared;(8) It was detected that whether natural lycopene had functions to regule blood-lipids and LDL antioxidation;(9) A C31 degradation piece of lycopene was found in the prostate gland of rat.

研究结果包括：[1]应用UV-VIS反射光谱法建立了番茄果实中番茄红素含量的无损伤、现场检测技术；[2]应用C30-HPLC-PDA-ELSD技术实现了对番茄红素几何异构体的分离，测定了不同顺式异构体的吸光系数，建立了天然番茄红素几何异构体组成的检测方法，为区分和鉴定人工合成品和天然产物奠定了基础；[3]证实了秋橄榄果实中的番茄红素资源具有工业开发价值，并建立了超临界CO_2萃取的实验室方法；[4]探索了提高番茄红素超临界流体萃取效率的方法，证明了物料前处理对提高萃取效率起了极其重要的作用；[5]观察了番茄红素在大鼠体内几何异构体组成的变化情况，发现了大量顺式异构体的存在，并证实了几何异构体组成在血清中发生了显著变化；[6]测定了天然番茄红素在大鼠体内的吸收率和在大鼠血清中的动态积累规律；[7]比较了不同番茄红素几何异构体淬灭单线态氧的能力；[8]检测了天然番茄红素是否具有调节血脂作用和抗低密度脂蛋白氧化的功能；[9]首次发现大鼠前列腺内存在番茄红素C31降解片段，并证实其仍具有淬灭单线态氧的能力。

Reported rates of inflammation vary mainly with the amount of tissue available for study, ranging from 44% for needle biopsies and 95% for transurethral resections to 98-100% for prostatectomies.

报道的炎症率主要随研究获取的组织数量而变，从细针穿刺活检的44％和经尿道切除的95％到前列腺切除的98-100％。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。