剂量学的

Gelsemium total alkaloids improved some blood and immune function of mice when it less than 0.30mg/kg body weight, but more than 1.5mg/kg body weight, the gelsemium total alkaloids can reduced some blood and immune function of mice; below the dose of 3%, GEB"s power can improve some blood and immune function of broilers, but GEB"s power can reduce some blood and immune function of broilers above the dose of 6%.

结论是：钩吻对小鼠和肉鸡的血液学及免疫功能的影响均存在着剂量差别，钩吻总碱稀释液在0.30mg／kg剂量以下，能够提高小鼠的某些血液指标与免疫功能(p＜0.05)，而在1.5mg／kg以上，则降低小鼠的某些血液指标与免疫功能(p＜0.05)；3％以下的钩吻干粉能够提高肉鸡的某些血液指标与免疫功能，而6％以上的钩吻干粉则降低某些血液指标与免疫功能。

Objective: This study was designed to characterize the pharmacokinetics and pharmacodynamics of high dose epirubicin in cancer patients.

目的：研究高剂量表阿霉素在肿瘤化疗患者体内的药物动力学过程，并初步探讨药效学特点。

After administerded for 30 days, all rats were killed and anatomized. The nephric exterior of model control group rats was offwhite, instead, that of Yi Shen Granule groups rats showed red grain in offwhite exterior. There were tumefaction of tissue and sediment of adenine in all kidney.

病理组织学观察发现，与空白组比较，造模动物肾小管均有扩张，给药后其扩张程度有显著性差异，采用半定量的方法对肾小管扩张程度进行分级比较，结果显示大剂量组动物肾小管扩张程度较轻。

Methods:Phamaco1ogy studies adopt orycto1agus curicu1us athero-sclerosis and musculus remembrance function bindrance model, set modelgroup, void control group, positiye control group, and NLKC high, middle,low dose group. The effects were observed by monitoring the inf1unenceof NLKC on blood and aorta 1 ipid, hemorrheology, l ipid peroxidation (LP0),thromboxanceB: Y 6--keto--prostag1andinF1 Q (6--keto--PGF, Q ), thick-ness and stage of atherosclerosis plaque, pathology of aorta andcoronary artery, and remembrance function.

主要药效学选用家兔动脉粥样硬化模型、小鼠记忆障碍模型等，设立脑力康胶囊不同剂量组、模型组、空白对照组、阳性对照组等，观察脑力康胶囊对血脂、血流变、过氧化脂质、血栓素B2（TXB2）、 6－酮－前列腺素F10（6－keto－PGF10）、主动脉脂质含量、动脉粥样硬化斑块厚度及程度、主动脉及冠状动脉病理形态、增强记忆等方面的影响。

In the long-period toxicity test, DCG was administered repeatedly for 60 days, the dose were 72.6,36.3,18.2 g/kg respectively(It refered to the dose of material,which amounted to 52.6,26.3,13.2 times of 50 kg human clinic use). There is no other abnormal changes about color patem,action,urine and stool,but cibation, hydroposia, body weight and index part of hematological and hematobiochemical parameters,coefficient and histomorphological figure of organs were examined during administration phase.The rats were examined in 21 days after the cessation of DCG, the abnormal changes of index was completely recovered.

定喘颗粒大鼠给药60 d的毒性试验，剂量分别为72.6，36.3，18.2 g/kg（相当于临床50 kg人用量的52.6，26.3和13.2倍），给药期间各组大鼠毛色、活动、二便均无异常变化，但给药组大鼠摄食、饮水、体重以及部分血液学、血液生化学指标和脏器系数有异常变化，停药后，上述异常变化指标均已恢复正常。

Their behaviour,activity,hair,feces were not found abnormal.Their food-intake and body weight were without any obvious variation;(2) After the experiment periods of three months and six months,the hematology examination of rabbits in all Ogroups and in all B groups was not made with distinct difference;(3) The blood biochemical measurement values in Ogroups and in B groups were basically similar;(4) When the systematic thanatopsia of laboratory rabbits,one rabbit each in a high-dose O group and a B group demonstrated 2-3 yellow-white circular nodes as large as a green bean in lingula pulmonis sinistri.Ohter organs were not found of obvious pathologic changes;(5)With the histopathology examination,the pathologic change of lung tissue seem by naked eyes was a focal suppurative inflammation under microscope.

其行为、活动、被毛、粪便等未见异常，进食量及体重变化未见明显差异；(2)实验期3个月、6个月的血清学检查，各药膏组与空白药膏组比较无显著差异；(3)药膏组与空白药膏组的血液生化测定值基本一致；(4)各药膏组实验兔的系统尸检表明，用药期空白药膏组和高剂量药膏组各有一只实验兔的肺心叶有2～3个黄白色绿豆大小圆形结节，其他脏器未见明显病变；(5)病理组织学检查，肉眼见到的肺组织病变镜检为局灶性化脓性炎症，其他组织未见病理性改变。

The physical status （body weight,growth rate and appetite）, hematological parameters, blood biochemistry, blood cotting, organ index, and tissue pathological changes of rats were checked in the 13th week,and 26th week of the administration and in four weeks after the stop of the administration.

160只SD大鼠，随机分为高、中、低剂量组及空白对照组，雌雄各半，每日灌胃1次，连续给药26周，观察大鼠的一般状况、体重、摄食量和给药13、26周及停药后4周大鼠的血液学、血液生化学、凝血功能、脏器系数、解剖学及病理组织学改变的情况。

Results The outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.

复方银杏叶片88.44， 17.69 mg /kg（为临床日剂量的50倍和10倍）给大鼠连续灌服13周，停药2周，分别测量大鼠体重，计算脏器系数，测定血液学和血液生化学指标，并作组织病理学检查。

ResultsThe outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.

方法复方银杏叶片88.44， 17.69 mg /kg（为临床日剂量的50倍和10倍）给大鼠连续灌服13周，停药2周，分别测量大鼠体重，计算脏器系数，测定血液学和血液生化学指标，并作组织病理学检查。

Objective: To explore the difference of clinical features and biochemical indices of hypercortisolism among male and female patients with Cushing's disease. Methods: Eighty-one patients (56 females and 25 males)with CD were selected.

手术确诊的库欣病患者81例，根据性别分为男性组25例，女性组56例，比较2组临床症状、影像学检查结果，血、尿皮质醇，血促肾上腺皮质激素，小剂量(1 mg和/或2 mg)及大剂量(8 mg)地塞米松抑制试验的结果。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。