剂量学的

The raw data was processed by using axial, coronal and double oblique multi-planar reformation; Images obtained were graded in terms of quality with a 5-point scale(5=excellent, 4=good, 3=fair, 2=poor, and 1=nondiagnostic). In grading image quality at axial MPR, The radiologic specialists focused on the subarcuate fossa, tendon of tensor tympani, facial recess, vestibular aqueduct and pyramidal eminence, In grading image quality at coronal MPR, attention was given to the scute, crista transversa, fenestra cochleae, lateral malleal ligament and snake eyes signature of cranial nerve, In the grading of the image quality at double oblique MPR, the radiologic specialists concentrated on the malleus, incus, stirrup bone, upper bony semicircular and aquaeductus fallopii, and then to implement statistical analysis. In order to choose the minimum tube current values and the maximum pitch that can satisfy the diagnosis request, image quality of axial, coronal and double oblique reformation images was compared with different tube current groups. 15 ears of volunteers were used to test the validity with the scanning parameter. Subsequently noise, MTF and dose length product were measured by phantoms in different tube current and pitch, the parameters obtained were compared and taken into statistics analysis.

扫描模式使用临床常用的颞骨螺旋扫描方式：管电压120 kV，准直宽度20×0.6 mm，视野200 mm，重建矩阵512×512，旋转时间1 s/r，重建层厚0.6 mm，重建间隔0.3 mm，分别改变管电流(380、300、200、160、120和80 mA)和螺距(0.8、1.0和1.2)进行扫描和重建，然后对颞骨进行横断面、冠状面和双斜面多平面重组，于重组后的横断层面图像上选取弓形下窝、鼓膜张肌腱、面神经隐窝、前庭导水管和锥隆起5个解剖结构，冠状面重组图像上选取盾板、横嵴、蜗窗、面神经的蛇眼征和锤骨外侧韧带5个解剖结构，双斜面重组图像上选取锤骨、砧骨、镫骨、上骨半规管和面神经管5个解剖结构，在双盲的情况下由放射学专家分别对各管电流和螺距下扫描的重组图像进行评分，随后进行统计学处理，从中筛选出满足诊断要求的最低管电流值和最大的螺距，分别采用患者25例(15耳)用该管电流值和螺距验证其可行性；然后利用模体分别测试各管电流和螺距下的图像的空间分辨率、噪声及其剂量长度积，并对测试所得参数数值进行比较和统计学处理。

Results:①All gallstones type Ⅰ and Ⅳ in animal models were dissolved quickly, however, MTBE showed somewhat toxicity in inhibiting CNS, so that the dose of MTBE should be controlled precisely.②No abnormal change of liver and renal functions of dogs were found before and after operations.③Choloecyst pathological sections of gallbladder suggested that no evident of damage and inflammation of gallbladder was of found. Hemopexis with reversible histological change was observed in hepatic sinusoid and centeral vein short time after administation of MTBE.

结果：①动物模型的Ⅰ、Ⅳ型结石均全部迅速溶解，但MTBE有一定毒性，其对中枢神经系统有一定的抑制作用，应用时须严格掌握单位时间内的灌注剂量及总量(控制在60ml左右)；②实验犬实验前后的肝、肾功能检查无异常；③病理检查结果提示MTBE对胆囊组织无明显损伤，无严重炎性反应，给药后短期内肝窦和中央静脉有凝血现象，但其组织学变化是可逆的。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

There were five groups in the examination of cellular levelK562 group,K562/A02 group,K562+ADM group,K562/A02+ADM group and K562/A02+TTD+ADM group）.The non-cytotoxicity doses to cell lines K562 and K562/A02 of TTD were got by MTT assay.Using flow cytometry (FCM assay to examine the intracellular ADM concentration.There were three groups in the examination of genic,zymologic and protein levelsK562 group,K562/A02 group and K562/A02+TTD group）.The mRNA expression of MDR was measured by fluorescent quantitative reverse transcriptase polymerase chain reaction(RT-PCR.The expression levels of glutathione-S-transferase and topoisomerase Ⅱ were determined by immunohistochemical technique.

细胞水平检测实验分5组（K562组、K562/A02组、K562+ADM组、K562/A02+ADM组和K562/A02+TTD+ADM组），采用MTT法检测TTD对K562和K562/A02细胞的非细胞毒性剂量，流式细胞术检测细胞内阿霉素的浓度，基因、酶学、蛋白水平检测实验分3组（K562组、K562/A02组和K562/A02+TTD组），采用RT-PCR法检测mdr1 mRNA的表达，免疫细胞化学方法检测谷胱甘肽S转移酶π和拓扑异构酶Ⅱ的表达水平，Western-blotting法检测P-糖蛋白和bcl-2表达。

Function and haematology;⑤investigate its growth-promotion and machanism;⑥do research on

提取了活性成份——生物碱；②研究它对动物的毒性和无毒性剂量；③研究了它对动物的毒性机理和病理；④进行了它对动物免疫功能和对血液学影响的研究；⑤研究了它的促生长作用及其机理；⑥还进行了残留及临床增重试验研究。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。