刺激血管的

Objective:The aim of this study is to determine the content of vascular endothelial growth factor and basic fibroblast growth factor in the wound fluid during maxillofacial soft tissue blast injury, and to evaluate their effects on angiogenesis of wound healing.Methods: The rabbit model of maxillofacial blast injury was made by KTY_04 blasting cap.

目的：探讨颌面部软组织爆炸伤愈合过程中血管内皮细胞生长因子和碱性成纤维细胞生长因子的分布和在伤口液中含量的动态变化，及其对血管再生的刺激作用。

Objective To determine the content change of vascular endothelial growth factor and basic fibroblast growth factor in the wound fluid and their effect on angiogenesis in the wound healing during healing of maxillofacial soft tissue blast injury. Methods The improved rabbit model of maxillofacial blast injury was made by KTY-04 blasting cap.

摘 要：目的探讨颌面部软组织爆炸伤愈合过程中血管内皮细胞生长因子和碱性成纤维细胞生长因子在伤口液中含量的动态变化及其对创伤愈合中血管再生过程的刺激作用。

Essential hypertension caused by neurovascular compression of the left ventrolateral medulla was associated with malbalance of vasomotor center in the dorsal medulla. The possible pathogenesis was the following:① An irritation of the left RVLM by pulsatile compression of an ectatic vessel would increase activity of central sympathetic neuron.② Neurovascular compression at the REZ of the cranial nerves Ⅸ and Ⅹ decreased excitation of parasympathetic nerve.③ Decreased sensitivity of afferent inputs to neuron of nucleus tractus solitarii in the sensory area lead to hyperactivity of central sympathetic nervous system due to pulsatile compression of the left RVLM.④ Neurocompression of the left RVLM and REZ in the left cranial nerves Ⅸ and Ⅹ lead to an overactivity of central renin angiotensin system.

3，结论：左侧延髓腹外侧Ⅸ、Ⅹ颅神经REZ动脉血管压迫所导致的高血压的发生与左侧延髓血管运动中枢对血压的调节失衡有关，其可能机制是：①左侧RVLM在搏动性血管压迫刺激下，中枢交感神经元活性增高；②左侧Ⅸ、Ⅹ颅神经REZ受压导致副交感神经兴奋性降低；③感受区孤束核神经元接受迷走神经传入冲动的敏感性减低，导致中枢交感神经活性增高；④左侧RVLM及Ⅸ、Ⅹ颅神经REZ受压引起中枢RAS活性增加。

We compared the ability of primitive and monocytic endothelial cell progenitors to stimulate vascular growth and healing in diabetes and investigated potential molecular mechanisms through which the cells mediate their in vivo effects.

我们在糖尿病模型中比较原始和单核系上皮祖细胞在刺激血管形成和愈合中的能力，从而根据细胞在活体内的自我调节调查其潜在的分子机制。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后，血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少，Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少，血小板聚集程度及红细胞聚集指数显著上升，病理切片显示胸主动脉内皮细胞破坏明显，脑心肾组织内的血管进一步增厚甚至几乎阻塞，导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR，脑体重比显著升高；心肌内出现明显的缺血梗塞疤痕灶，心体重比显著升高；肾小球明显萎缩、玻璃样变性，肾小管也变性甚至坏死，使肾硬化程度显著增加呈颗粒性固缩肾，肾体重比也显著减少。

AngiotensionⅡand endothelin-1 are two important vasoactive peptide,having powerful vasoconstricting and hemodynamic function,except this,both have nonhemodynamic effects as growth factor to induce proliferation,hypertrophy,to stimulate synthesis of matrix proteins,furthermore,also to inhibit matrix degradation, even to mediate inflammation reaction.

血管紧张素Ⅱ(angiotensinⅡ，AngⅡ)和内皮素1(endothelin1，ET-1)是两个重要的血管活性激素，除了血流动力学作用外，还有非血流动力学作用，如促进细胞增生、肥大，刺激细胞外基质的合成并抑制其降解，介导炎症反应。

Classically, Ang Ⅱ is well known to cause potent increases in systemic and local blood pressure via its vasoconstrictive effect, to influence renal tubules to retain sodium and water, and to stimulate aldosterone release from the adrenal gland.

众所周知，Ang Ⅱ通过它的血管收缩效应导致系统和局部的血压增高并影响肾小管的钠水潴留以及刺激肾上腺的醛固酮释放。

Weibel-Palade bodies are specialized cigar-shaped secretory organelles in endothelial cells, which contain a variety of biologically active molecules. These contents can be released rapidly by stimulation and involved in hemostasis, inflammation and angiogenesis.

Weibel-Palade小体(Weibel-Palade body， WPB)是血管内皮细胞一种特殊的分泌性杆状细胞器，含有多种生物活性分子，受到刺激后可以非常迅速的释放这些内容物，参与止血、炎症和血管生成等生理功能。

When the baby when a normal birth, the baby's head will be squeezed, the pressure of the baby's birth canal is a good stimulation of the sensory organs, which stimulate the conduction brain, right brain circulation of blood to enhance stimulation of the brain's respiratory center to provide more material basis of the baby's hearing and so on is a very good training, while caesarean section babies have lost the opportunity to exercise.

当宝宝正常分娩的时候，宝宝的头部会受到挤压，产道的压迫对宝宝的感觉器官是一种良性刺激，这种刺激传导大脑，对脑部血管循环加强刺激，为脑部的呼吸中枢提供更多的物质基础，对宝宝的听觉等是一次非常好的训练，而剖腹产的宝宝则失去了这一锻炼机会。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。