刺激药

Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果：新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用；对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用，且在相同剂量下，外涂给药和ig给药的作用无明显差异。

Observing the effects of DS on acetic acid-induced writhing and increased capillary permeability in mice when it was administered intraperitoneally, the granuloma formation induced by cotton pellet in rat when it was applied locally, and the mucous membrane irritation of DS lozenge.

观察双氯芬酸钠低剂量低浓度腹腔给药对醋酸致小鼠扭体作用及毛细血管通透性增加的影响，局部给药对大鼠棉球肉芽形成的影响，局部长时间接触对的刺激作用。

The theoretical plasma concentration versus time was calculated for all patients on the basis of the pharmacokinetic models described by Sheiner et al. Predicted effect versus time was calculated by following the pharmacokinetic-pharmacodynamic link model. The Ke0 was estimated by fitting a sigmoid cure. Group B was given the drug in a bolus of 2 mg.kg-1 and the Ke0 was calculated according to the method reported by Minto et al.

22例ASA ⅠⅡ级择期手术患者，A组(n=11)持续输注罗库溴铵0.03 mg·kg-1·min-1直至4个成串刺激降至20% 30%，B组(n=11)单次注射罗库溴铵2 mg·kg-1.A组血浆药物浓度用Sheiner等报道的药代动力学参数模拟计算，预测效应根据药代动力学-药效学关系公式换算，Ke0通过S型曲线拟合计算。B组采用Minto等提出的方法计算。

The C response of semimembranous and semitendinous myoelectricity evoked by stimulation to rat intraplanta with high intensive currents was used to illustrate the peripheral analgesic effect of BmK when given in local cutaneous sensory fields.

方法采用局部皮肤感受野给药，以强电流刺激大鼠后肢趾部诱发半膜半腱肌发放C反应，观察对外周神经系统的镇痛作用；经脊髓蛛网膜下腔给药，以大鼠足跖辐射热痛阈的变化为中枢镇痛效应的观察指标。

Methods The procedure used autologous disc of the rats from the coccygeal intervertebral discs to impose direct pressure to the L5 dorsal root to induce an animal model of lumbar disc herniation. After the epidural tube was inserted, early prophylactic therapy and late remedial dexamethasone therapy were conducted to observed the PWMT of both hind paws of the rats.

取大鼠自体尾部椎间盘组织置于L5神经根下，建立椎间盘突出动物模型，然后硬膜外置管，采用早期预防性给药及晚期治疗性给药方法，观察地塞米松对大鼠后足底机械刺激疼痛阈值的影响。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

METHODS To count rabbit nictation times,short-time multiple eye drops irritation(once per 15 minute for continuously 2 hours) and long-time eye drops irritation(5 times per day for continuously 4 weeks).

方法计数兔眨眼次数、短期多次给药眼刺激(1次/15min，连续滴眼2h)和长期给药眼刺激(5次/日，连续滴眼4周)作用。

Mechanical and cold allodynia were observed at preadministration and 15, 30, 60, 90, 120, 150, and 180 min after drug administration and were quantified by measuring withdrawal frequencies to stimuli with von Frey filaments and 100% acetone, respectively.

于给药前、给药后15、30、60、90、120、150、180分钟记录机械和冷异常，且经常用 von frey 细丝和100％丙酮分别刺激量化测量停药后反应。

On the normotensive rat, bilateral microinjection of L-arginine (16 n mol/0.1 ul/site), a precursor of nitric oxide into the rVLM, caused a decrease in BP, HR and the pressor response induced by the dPAG stimulation, while microinjection of NG-methyl-Larginine (L-NMMA, 16 n mol/0.1 ul/site), a blockade for NO to form, into the rVLM bilaterally, caused an increase in BP, HR and the pressor response induced by the dPAG stimulation. There was no effect of both drugs mentioned above on the tachycardiac response induced by the dPAG stimulation.

五、在正常血压大鼠，于双侧rVLM微量注射一氧化氮前体(16nmol/0.1μl/site)可引起BP降低、HR减慢、以及电刺激dPAG诱发的防御性升压反应减弱；而于同区微量注射生成一氧化氮的拮抗剂N〓-甲基-L-精氨酸(16nmol/0.1μl/site)则可引起BP升高、HR加快、以及电刺激dPAG诱发的防御性升压反应增强；而上述两药对电刺激dPAG诱发的防御性加快心率反应均无明显作用。

Objective To observe the effects of urapidil,phentolamine,glyceryl trinitrate or phenylephdrinum on the isolated tracheal smooth muscle in rabbit.Methods KCl,Ach and electrical stimulation were used to induce the contraction of the isolated rabbit tracheal smooth muscle.

目的 观察常用降压药和升压药对气管平滑肌张力的影响，探讨其作用机制方法观察不同浓度乌拉地尔对氯化钾、乙酰胆碱、电脉冲三刺激因素诱发的兔离体气管平滑肌收缩力变化的影响；观察酚妥拉明、去氧肾上腺素和硝酸甘油对电刺激诱发的气管平滑肌收缩力的影响。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。