刺激

In training the computer system provided sequential stimulation to three key muscles groups(iliacus, quadriceps, shank triceps), In 3 cases with different level of spinal cord injury, the clinical application and curative effects were observed with this system.

锻炼每周进行3次，每次踏车10min，锻炼过程中，电脑控制多通道电刺激器在不同象限内顺序刺激双下肢的骼肌、股四头肌、小腿三头肌来完成踏车运动。在锻炼中记录自行踏车时间，并观察血压、脉搏的动态变化。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Results The local intracortical connection, which is involved in mediation of downward information flow across layers II-VI, was identified by electrical stimulation at layers II-III.

结果 刺激S1后肢代表区脑片的II-III层，可鉴定出局部皮层内的连接回路，而刺激IV层则鉴定出丘脑皮层间的连接回路。

Results Preserving bilateral S1 anterior and posterior roots intact combined with rhizotomies of L7 and S2～3 posterior roots, intradural stimulation of S1 posterior root producedan increase of bladder and urethral pressure similar to that of stimulation of the S1 common root in extradural.

结果 保留2侧S1前后根完整，电刺激同平面S1的总根或后根，膀胱尿道的压力反应相同；切断两侧S1前根，刺激同平面的S1后根，膀胱尿道的压力反应显著降低，仅为前后根完整时的7%～12%。

BACKGROUND: In this study we evaluated the minimum stimulatingcurrent associated with intraneural needle placement and sonographicappearance of intraneural injection.

背景：本实验作者评估了神经内刺激针最小刺激电流神经内注射的超声像图。

The most important part of an electronic cochlea system is the multiple-channel receiver-stimulator implemented in this thesis, which will be implanted into the mastoidal cavity nearby the cochlea. Data signals transmitted by an external speech processor are received through a tuned inductive coil. The power supply for the receiver-stimulator is derived from the rectified and filtered data signals. Meanwhile, the clock and the data envelope are extracted.

本文实现的多道（22根电极）电子耳蜗接收刺激器是人工电子耳蜗系统中的重要组成部分，它将直接被置入患者耳蜗附近的乳突骨腔中，通过电感耦合接收从体外语音处理器发射的数据信号，通过整流滤波为接收刺激器提供电源，同时提取时钟信号和数据包络[31]。

At eccentricities of 20 degree, VEP yielded the largest responses to gratings perpendicular to the visual field meridians through stimulus locus and the lowest responses to meridionally oriented gratings.

在距中央凹20°视角同心圆的八个刺激位置上，VEP反应幅度对与向心线垂直方位的光栅刺激，有统计意义上的优势。

In communication exciting circumstance falls, when exciting frequency is changed, motorial yuan ISI alignment goes out to add periodic phenomenon now.

在交流刺激情况下，当刺激频率改变时，运动神经元的ISI序列出现加周期现象。

In 1999, Struijk found that the myelinated nerve could be excited by transverse field induced by pulsed magnetic stimulation without the effect of tissue unhomogeneities and bends in the nerves.

因此，在近几年的神经磁刺激研究中，也局限于讨论感应电场纵向分量的作用，以纵向场负的一阶导数极大值作为刺激方式的选取及线圈改进的衡量标准。

Objective: To study the impact of myodynamia, spasm degree, limb function and activities of daily living of hemiplegia spasm after a stroke treated by acupuncture Spasm side and Non-Spasm side point respectively in the strong and weak way.

目的：探讨分别以强刺激、弱刺激方法针刺痉挛侧、非痉挛侧穴位治疗脑卒中后痉挛性偏瘫肌力、痉挛程度、肢体功能活动及日常生活能力的影响。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新