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Because different cell lines may show various levels of susceptibility to adenovirus infection and virus production, non-selectively replicating wtAd5 was used to be a comparison with the tested conditionally replicating adenovirus CNHK500.ONYX-015, the first replication-competent adenovirus entered into clinical trials was also used to be a comparison. We used virus proliferation assay, cell viability assay and western blot to evaluate the proliferation and cytolysis selectivity of CNHK500. Results demonstrated that the CNHK500 virus proliferation multiples in breast cancer cell lines after 48 hours is similar to that of wtAd5, ONYX-015 virus proliferation ability is less than that of CNHK500 in cancer cells.

然后,通过与ONYX-015(E1B 55 KD a蛋白缺失的2型和5型嵌和型腺病毒,美国ONYX生化制药公司研制)、wtAd5进行对比,利用病毒增殖实验和细胞生长抑制实验,验证了CNHK500选择性增殖能力和肿瘤特异性杀伤作用;利用Western Blot检测CNHK500腺病毒E1A和E1B在乳腺癌细胞和正常成纤维细胞中的表达差异,揭示了腺病毒肿瘤靶向性的机制;利用携带绿色荧光蛋白的CNHK500-EGFP感染乳腺癌细胞株和正常成纤维细胞株,直观地观察其感染乳腺癌细胞的能力和在乳腺癌细胞中的增殖过程。

The research indicates that:(1) detecting λmax (277nm) can identify Metronidazole Buccal Tablets prepared by Chongqing Medical College;(2) detecting λmax (321nm) and λmin (265nm) can identify Metronidazole Disodium Phosphate for Injection prepared by Chongqing Medical College;(3) detecting tr (6.7min) in HPLC-UV spectrum can identify Ceftriaxone Sodium for Injection prepared by Chongqing Keru Pharmacy Co.;(4) detecting tR (10.2min) 6.7min in HPLC-UV spectrum can identify Clarithromycin Tablets prepared by Harebin Yida Pharmacy Co.;(5) detecting λmax (254nm) can identify Potassium Sodium Dehydroandroan Drographolide Succinate prepared by Hong Kong Yaohen Co..

结果表明:①测定紫外最大吸收波长λ_(max277nm可鉴别重庆医科大学医药研究所制备的甲硝唑口颊片;②测定紫外最大吸收波长λ_(max321nm和最小吸收波长λ_(min265nm可鉴别重庆医科大学医药研究所制备的注射用甲硝唑磷酸二钠;③测定HPLC-UV中的保留时间(t_R6.7min)可鉴别重庆科瑞制药股份有限公司制备的注射用头孢曲松钠;④测定高效液相色谱的保留时间(t_R10.2min)可鉴别哈尔滨伊达制药厂提供的克拉霉素片;⑤测定紫外最大吸收波长(又max254nm)可鉴别香港耀恒公司提供的炎琉宁。

In the 2006 CBC Massey Lectures — the bestselling and most eagerly anticipated lecture series of the year — renowned ethicist and McGill University professor Margaret Somerville tackles some of the most contentious issues of our times, and proposes a brilliant new kind of ethical language and thought to help us navigate them.

中文概要:在加拿大广播演讲中,索默维尔医生的演讲是最热门和吸引人的,也是当今一直争论的议题。大家已经日渐意识到,生命科学领域和生物制药领域的飞速进步带给人类巨大的福利,然而,促使科学进步的知识、工具、技术,也可能被滥用,进而造成无可挽回的伤害。

Jinri Group, a Hong Kong pharmaceutical enterprise, made a survey on Zhejiang Province that is a key-consuming province of health-caring products. The result indicated that among 30 main products, 80% emphasized on the functions while 16.7% on kinship and the rest are 3.3%. And of 24 brands focusing on functions, many concentrated on functions of anti-fatigue, anti- caducity and blood fattiness adjustment that occupied 26.7%, 23.3% and 20% respectively, thus, obviously, a similarity appeared.

根据香港一家制药企业——金日集团对中国内地消费品重点消费省份浙江省的调查显示,主要的30种保健品品牌中,在传播中强调功效的占80%,强调亲情的占16.7%,其它3.3%。24种强调功效的保健品品牌中,大多将功效集中在缓解疲劳、抗衰老和调节血脂三个方面,分别占所调查品牌数的26.7%、23.3%和20%,出现明显雷同的现象。

Hello, I am a 13-month baby's mother, my baby and also like you, then used after the cream has been like a species, there are eczema on the James, two days a lot better, just 34 days in general you remember what the name of the drug is the Shanghai Schering Pharmaceutical Co., Ltd."艾洛松, mometasone furoate cream" before going to bed to help your baby every day to wash clean, in place of eczema James,"James once a day, Oh, remember that only a "puff and then put like, just a few days, the baby all right out of eczema, and puff your skin is called the Provincial Hospital doctor about the kind of powder only where, because of their hospital formula, if the local eczema can not be used to break the paste, and right, you are right Fuzhou?

你好,我是一个13个月宝宝的妈妈,我的宝宝也和你一样,后来用了已种乳膏后就好了,有湿疹就涂,两天就好多了,一般三四天就好了,你记一下药名是上海先灵葆雅制药有限公司的《艾洛松,糠酸莫米松乳膏》你在每天睡前帮宝宝洗干净,在出湿疹的地方涂,《一天涂一次,记住只能一次哦》然后在打上粉扑就好,几天就好了,宝宝出湿疹没事的,粉扑你到省立医院皮肤科叫医生开一下,那种粉只有那里有,因为是他们医院的配方,如果湿疹的地方破了就不能用要膏了,对了,你是福州的吗?

The thesis was designed to optimize the cultures of producing D-LA bySporolactobacillus sp. and analyze the effects on fermentation in order to produceD-LA effectively.D-lactic acid is considered to be a very important chemical compoundas a chiral material or intermediate in organic synthesis. D-LA is a prosoma of manychiral compounds with applications not only in the pharmaceutical and cosmetic industry but alsoin highly efficient and lowly toxic pesticide and herbicide.

本研究的目的是通过对芽孢乳杆菌发酵工艺的研究,建立一条产物光学纯度高、工艺简单,成本较低的D-乳酸生产路线。D-乳酸是重要的手性中间体与有机合成原料,是多种手性物质的前体,广泛应用于制药、化妆品和高效低毒农药及除草剂等领域的手性合成。

Advertisement of Rx medicine is forbidden in China, which is similar to the international regulations.

医院市场是制药厂商面对的最大的市场,尽管各个厂商的市场行为非常的强,厂商所能采用的销售促销方式是非常有限的。

The ultrafilteration is applied in the separation and concentration of the zymin, it can be operated in the normal temperatures, overcome the effects heat does to the quality of the fermented products, abstract small molecular admixtures, and guarantees filtrates purity and quality; Filtering process does not change, the energy consumption and the cost compared with the traditional method are lower; The equipment running is simple, and is easy to operate and the control, thus it quickly became concentration separation craft the first choice of concentration separation such as biology medicine manufacture.

现在采用超滤技术进行酶制剂的分离浓缩,则可在常温下操作,克服热对发酵产品品质的影响;除去其中的小分子杂质,保证滤液的纯净度和品质的良好性;过滤过程无相变,能耗和成本较传统方法都低;设备运行简便,易于操作和控制,因而很快成为了生物制药等行业分离浓缩工艺的首选。

I dont expect you will really understand the beauty of the softly simmering cauldron with its shimmering fumes, the delicate power of liquids that creep through human veins, bewitching the mind, ensnaring the senses… I can teach you how to bottle fame, brew glory, even stopper death — if you arent as big a bunch of dunderheads as I usually have to teach.

我并不奢求你们会真正地懂得制药技术的美妙之处。想想看,用大汽锅煨药材时,药水慢慢地沸腾,白色的烟雾袅袅升起……还有人体静脉里流淌的液体,那具有无比精妙力量的液体……简直能让你的心醉掉,让你的所有感官着迷……我能教会你们怎样罐装名誉,怎样酿造光荣,甚至说……储存死亡……只要你们不要像我以前教的那一帮蠢才们一样愚蠢就行。

Vacuum belt hydroextractor (also named fixed rubber belt vacuum filter) is a new solid-liquid separating equipment with high efficiency and continuous operation, based on introduction, assimilation and digestion of the techniques of the same products overseas. It has achieved solid-liquid separation by making full use of material gravity and vacuum suction. In terms of its structure, filtering section is arranged horizontally lengthwise, and length of filtering section can be fully used to fulfill in turn such a process covering filtering, rinsing and sucking up, with advantages of high filtering efficiency, productivity, good rinsing effect, wide application range, simple operation, stable running, convenient maintenance and service.

真空皮带脱水机也叫固定真空室式橡胶带式过滤机;是我公司在引进、消化和吸收国外同类产品技术基础上,研制的一种新型、高效、并可连续操作的固液分离机械设备,同时它也是一种充分利用物料重力和真空吸力实现固液分离的机械设备;在结构上真空区沿水平方向布置,利用真空区的长度可以连续完成过滤、洗涤、吸干等不同工艺过程,具有过滤效果高、生产能力大、洗涤效果好、应用范围广、操作简单、运行平稳、维护保养方便等优点;特别适合于过滤固相颗粒粗、密度大及滤饼需要多次洗涤的悬浮液料浆,可以广泛应用于冶金、矿山、化工、造纸、食品、制药及环保等工业部门的固液分离;尤其在湿法烟气脱硫中的石膏脱水方面有着很好的应用。

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And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47:5 法老对约瑟说,你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

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