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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞,导致细胞生长的抑制和凋亡罗伯托利,斯特凡Purgato ,苏埃洛卡默琳,拉菲尔Fronza ,梅奥尼博洛尼亚,西蒙娜Alboresi ,莫妮卡弗兰索尼,罗伯托Corradini ,斯特凡诺斯福尔扎,安德烈Faccini ,杰森先生Shohet , Rosangela Marchelli ,和安德烈Pession儿科,博洛尼亚大学,圣' Orsola -马尔皮基医院,博洛尼亚,意大利;有机部和工业大学化学帕尔马,帕尔马,意大利和3Center的细胞和基因治疗,德州儿童癌症中心, Baylor医学院,得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞,针对一个独特的序列反义DNA链的第2外显子,并与在MYCN 其氨基端为核定位信号肽。

Harmodius and Aristogiton, Brutus, Chereas, Stephanus, Cromwell, Charlotte Corday, Sand, have all had their moment of agony when it was too late.

阿尔莫迪乌斯和阿利斯托吉通、布鲁图斯①、谢列阿②、史特方纽斯、克伦威尔③、夏绿蒂·科尔黛④、桑得⑤,他们事后都曾有过苦闷的时刻。

In this way, Starkiller became, in effect, an original architect of the Rebel Alliance by facilitating the meeting on Corellia of the Alliance's founders: Garm Bel Iblis, Mon Mothma, and Bail Organa.

这样,弑星者实际上成了义军同盟的缔造者。在他的帮助下,义军同盟创始人在科瑞利亚星球召开会议,与会者包括:加姆·贝尔·伊布利斯、蒙·莫思玛和贝尔·奥加纳。

Active in contemporary music since studying at Mills College, California,with composers Darius Milhaud,Leon kirchner,and Leon Kirchner,and Lawrence Moss, she also holds graduate degrees in musicology form Columbia University.

早年就读于加利福尼亚州米尔斯大学,学生时期就同作曲家达利斯·米哈德,莱昂·柯西纳和劳伦斯·莫斯合作,活跃于当代音乐领域。谢丽尔同时拥有哥伦比亚大学音乐学硕士学位。

Godfrey Philips executive V-P Nita Kapoor said Marlboro is being made as per Philip Morris quality standards.

戈弗雷·菲利普斯执行副总裁妮塔·卡普尔说,万宝路是按菲利普莫里斯的质量标准制成的。

Kane accidental drowning , dublin bay , philip moisel pyemia , heytesbury street , michael hart phthisis , mater misericordi aelig ; hospital , patrick dignam apoplexy , sandymount

凯恩197不慎淹死在都柏林港湾,菲利普莫依塞尔198脓血症,死在海蒂斯勃利街,迈克尔哈特199肺结核,殁于仁慈圣母医院,帕特里克迪格纳穆脑溢血,殁于沙丘。

Four of the ten most cited faculty at Duke are relatively recent additions (Curtis Bradley, Erwin Chemerinsky, Mitu Gulati, and Ernest Young), while Duke's high median citation score reflects other additions of productive and influential scholars to the faculty in the last 4-5 years, including Stuart Benjamin, Arti Rai, James Salzman, and Lawrence Zelenak among others.

杜克前十名引用最高的师资当中的四位(科提斯·布拉德利、埃尔文·凯莫林斯基,、米图·古拉提、安思特·杨)都是近来新增的,同时杜克的高人均中数引用率表明了高产并有影响力的学者在过去4-5年的入盟,包括斯图亚特·本杰明、阿尔提·莱伊、詹姆斯·萨尔兹曼以及劳伦斯·泽勒纳克等人。

A mention of a forest-dwelling horse known to the Mbuti pygmies of Congo, in the memoirs of Sir Henry Morton Stanley, caught the attention of Sir Henry Hamilton Johnston, a Victorian explorer and colonial administrator—and longtime dreamer of unicorns.

一个关于丛林居住的马为刚果,为了几年亨利莫顿斯坦利爵士,引起了亨利汉密尔顿约翰斯顿爵士的注意力,一位维多利亚时代的探险家和殖民地统治者—长时间地梦见独角兽。

A mention of a forest-dwelling horse known to the Mbuti pygmies of Congo, in the memoirs of Sir Henry Morton Stanley, caught the attention of Sir Henry Hamilton Johnston, a Victorian explorer and colonial administrator—and longtime dreamer of unicorns.

一位维多利亚时代的探险家,殖民管理者和独角兽梦想者亨利·汉密尔顿·约翰斯顿公爵被亨利·莫顿·斯坦利的传记所吸引。据传记记载,有一种生活在森林里的马,它为刚果的穆布提矮人所熟知。

The Speyer Cathedral, officially the Imperial Cathedral Basilica of the Assumption and St Stephen, in Latin: Domus sanctae Mariae Spirae (German: Dom zu Unserer lieben Frau in Speyer) in Speyer, Germany, is the seat of the Roman Catholic Bishop of Speyer and is within the Archdiocese of Bamberg.

施派尔大教堂,正式帝国大教堂圣母升天大教堂和圣士提反,在拉丁美洲:紫花多莫斯sanctae绣线菊(德语:大教堂祖Unserer利本弗劳在斯派尔)在Speyer,德国,是天主教主教施派尔和座位是在班贝格总教区。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。

A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。