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TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

VOA的SpeciaI English节目一般历时半小时,依次为10分钟的News,接着为5分钟的Environment Report、A griculture Report、Science Report、Development Report、People in the News、Words and Their Stories,最后是15分钟的 This ls America、Science in The News、Ex ploration、The Making of a Nation

上述各种节目中，以News为最难，因为它覆盖范围广，政治、经济、军事、文化和科技等等，用词量比其他节目多，理解时需要各种背景知识。但是如果连续听，听懂前一天的内容后很利于听懂以后同一事件的消息。

In group E, which had just experienced 30-minute cold storage without rewarm ischemia, hepatic function could well be recovered in a short time during reperfusion. On the contrary, in group F、G and H, which had experienced rewarm ischemia for 15, 30 and 60 minutes respectively following 30-minute cold storage, hepatic function suffered the more severe damage with the more prolonged rewarm ischemia during reperfusion.

在对供肝复温缺血-再灌注损伤的研究中发现，供肝于再灌注期间，仅低温保存30分钟而无复温缺血的E组供肝功能于短时间内即可得到很好的恢复，但低温保存30分钟后又分别经历15、30、60分钟复温缺血的F、G、H三组供肝，其肝脏功能却遭到了明显的损伤，且复温缺血时间越长者，损伤程度越重。

"An average amount of exercise was defined as 60 minutes per week," Sprod told Reuters Health,"so anyone exercising less than 60 minutes was below average, above 60 minutes was above average, and anyone that considered themselves 'highly competitive' chose that category."

&平均运动量被界定为60分钟，每星期，& Sprod告诉路透社记者，&所以任何人行使不到60分钟，是低于平均水平，高于平均60分钟以上，和任何人都认为自己是'高度竞争的'选择的类别。&

"An average amount of exercise was defined as 60 minutes per week," Sprod told Reuters Health,"so anyone exercising less than 60 minutes was below average, above 60 minutes was above average, and anyone that considered themselves 'highly competitive' chose that category."

Sprod告诉路透社：平均运动量确定为60分钟，运动量不足60分钟的在平均水平以下，运动量超过60分钟的在平均水平以上，那些认为自己很有竞争力的人会选择这一类。

This relative was able to start a multi-point meeting in 17 minutes, was able to share her desktop and present an online presentation in under 25 minutes, and even started using the voting and whiteboarding features within 30 minutes – all of it witnessed but uncoached.

这种相对能够启动一个多点，在17分钟的会议，能够分享她的台式机和目前线上简报（Microsoft PowerPoint中）在少於25分钟，甚至在投票开始使用和白板功能，在30分钟内-所有它见证但

The travelers have two options to reach the Jumeirah island , either they can drive for 15 minutes from the Phuket International Airport , take a water taxi and travel for 3 minutes to the Baramabay private island , or they can choose the classier and faster alternative to reach the Jumeirah island which is a 5 minutes helicopter ride directly from the airport to the helipad of the island .

该旅客有两个选择，以达到朱美拉岛，无论是他们可以驱动15分钟，从普吉岛国际机场，采取水上出租车和旅行为3分钟到baramabay私人岛屿，或者他们可以选择classier和更快的替代达到在朱美拉岛，这是5分钟，坐直升机直接从机场到停机坪，该岛屿。

In a match that left Milan on the verge of the knockout stages, the brilliant Brazilian scored a sixth-minute penalty before starting and finishing a rapier-like counterattacking move on 22 minutes and then completing his hat-trick with a spectacular 56th-minute strike.

在一场让米兰差不多确保出线的比赛中，这位耀眼的巴西球星在开场后六分钟打入了一粒点球，随后在22分钟高速突破后射门得分，最后在56分钟时完成了帽子戏法。

In a match that left Milan on the verge of the knockout stages, the brilliant Brazilian scored a sixth-minute penalty before starting and finishing a rapier-like counterattacking move on 22 minutes and then completing his hat-trick with a spectacular 56th-minute strike.

在比赛中，米兰以压倒性的优势赢得了比赛，这位巴西人大放异彩，在开始第六分钟就取得了进球，在22分钟时通过犀利的反击又进一球，最后在56分钟以进球完成了惊人帽子戏法。

On the other hand, the intensity of ultrasound stated, percutem transit dose of drug could be increased along with the time at the range of 10 min to 30 min. However, if it was given ultrasound over 40min, percutem transit dose of drug would be reduced significantly. Therefore, it was supposed that skin temperature was increased during a long time of ultrasound, and the skin would be damnified.

超声强度一定时，超声时间由10分钟加长到30分钟时，药物的累积经皮渗透量增加，当超声时间增加到40分钟时，药物的经皮渗透量却明显减小，可能是由于超声时间加长后，使皮肤温度显著升高，对皮肤造成损伤所导致的结果。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。