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Compared with classical cytotoxic T lymphocytes , NK cells are superior in the following aspects: NK cells are among the first cell types to be activated after intracellular pathogen stimuli, the activity of NK cells peaked between 1 to 3 days, retained during the first 7-10 days, and the T cells response emerged only after 7 days when the NK cell responses begin to decline; though comprising of only 10%-15% of peripheral lymphocytes, NK cells mobilize most of the cell populations in a strong and high level response to different invasions, and act as key factors at early defense before a specific immune response could mount, while only certain clones were involved in T cell response; NK cells kill virus-infected or malignant transformed cells without pre-sensitization and without restriction by major histocompatibility antigen, which is usually a mechanism of immune escape to T cell recognition by virus-infected or tumor cells, thus NK cell in complementary with T cells play crucial roles in tumor and virus eradication.

NK细胞以其强大的细胞毒活性为特征,与细胞毒性T细胞相比,NK细胞具有如下特点:NK细胞虽然只占外周血淋巴细胞的10-15%,但是对刺激性因素产生应答的过程十分迅速,一次可以调动大多数细胞共同参与,而不是几个克隆的活化,免疫应答的强度高;病毒感染或恶性转化细胞的一个主要特征是细胞表达的MHCⅠ类分子下降或消失,并借助这一机制逃避特异性T细胞应答的识别,NK细胞介导的杀伤活性无需抗原刺激,不受MHCⅠ分子表达的限制,从而与T细胞应答互为补充发挥免疫防御的功能;NK细胞的免疫活性可以被多种细胞因子上调,其中IFNα,IL-2,IL-12,IL-15和IL-18具备更强的作用;NK细胞具有强大的细胞因子分泌功能,对于启动T细胞特异性应答必不可少。

The results showed:among the 7 isolates, five isolates of HY3、GY1-3、ZJ1-1、HP1、FC3 had same colony shape, irregular shape, liquidlike, slimy, opacity with smooth surface;the other two isolates had same shape, irregular shape, dry, opacity with coarse surface. By inoculating eucalyptus with the 7 isolates, the plants were infected apparently, and the young plants of eucalyptus in control experiment with tap water were not infected. By cultivating eucalyptus cuttings with the bacterial suspensions without EPS, the incidence of disease was very distinct,but compared with the former bacteria suspension,the incidence of disease has decreased at different degrees. By screening out two isolates of strong pathogenicity and two isolates of weak pathogenicity from the 7 isolates,making the bacterial suspensions with them to inoculate the young plants of eucalyptus, two treatments of cutlings and ramets with rats were set with 5 repetitions in every treatment, the results of data analysis showed: for the cutlings, the bacterial contents in upper and middle parts、upper and lower had significant difference;for ramets with roots, the bacterial contents in upper, middle parts, lower had significant difference between each other; For both the cutlings and ramets with roof, the bacterial contents in xylem and phloem had significant difference. The interaction between vertical and horizontal parts for the bacterial content had significant difference. For the two isolates of HY3 and 93B which were screened out at last,their activities of the cellulase were: 1.955ug/ and 1.288ug/ respectively, and had significant difference; the activities of pectase were: 1.325 ug/and 1.24ug/ respectively, and had no significant difference. The content of EPS extracted from the two isolates of HY3 and 93B was very different: 7.08x10-8ug/cell and 5.17x10-8ug/cell.

结果显示:7个菌株中,其中5个菌株HY3、GY1-3、ZJ1-1、HP1、FC3的菌落形态相同:不规则形状、流体、粘性、不透明、表面光滑;另外2个菌株93B、GN1菌落形态相同:不规则形状、干燥、不透明、表面粗糙;用7个菌株接种剪根桉树苗,发病情况非常明显,而自来水对照实验中桉树苗却不发病;无EPS菌悬液培养桉树剪根苗,发病率也很明显,但是相比原菌液,则发病率有不同程度的下降;从7个菌株中间筛选出来2个强致病性菌株和2个弱致病性菌株,用它们配制菌悬液培养桉树苗,设置剪根和不剪根两个处理,每个处理设置五个重复,数据分析结果显示:对于剪根苗,上部和中部、上部和下部的含菌量有显著的差异,中部和下部含菌量差异不显著;带根苗,上部、中部、下部含菌量彼此之间差异显著;不管是剪根苗还是带根苗,木质部和韧皮部含菌量之间的差异都非常显著;上中下与木韧交互作用中,含菌量差异非常显著;最后筛选出来的强弱2个菌株HY3和93B,它们的纤维素酶活性分别为:1.955ug/和1.288ug/,具有显著的差别;果胶酶的活性分别为:1.325 ug/和1.24ug/,没有显著的差别,而且HY3和93B两个菌株细胞分泌的胞外多糖的含量差异很显著,分别为:7.08×10-8ug/cell和5.17×10-8ug/cell。

The results indicated that (1) the 147Pm, 141Ce and 147Nd had strong adsorptivity in soil, so they were hard to transfer and easily accumulated in soil or sediment;(2) all the organisms (5 aquaties and 4 eatable plants) tested showed apparent 147Pm concentrating capabilities;(3)the residues of 147Pm, 141Ce and 147Nd were unevenly distributed in the animal's viscera and tissues, higher residues were found in bone, marrow, eye, brain, heart, adipose and testis, showing selective accumulation;(4) with intraperitioneal dosing of Nd or Ce 200mg ·kg -1 apparent inhibition to gonadial hormone secretion in mice was found and with 200 and 800mg·-1 of Ce added in feed, the malformation rate of spematozoon showed higher.

综合研究结果表明: 14 7Pm、14 1Ce和14 7Nd在土壤中具有强的吸附性,而且难以迁移,易于在土壤和底泥中积累;( 2 )供试的 5种水生生物、4种陆生食用植物对14 7Pm均具有明显的富集性;( 3) 14 7Pm、14 1Ce、14 7Nd在动物体内脏器和组织间呈不均匀分布,在骨骼、骨髓、眼、大脑、心脏、脂肪和睾丸中残留量较高,表现了明显的选择性蓄积;( 4 )一次性腹腔注射2 0 0mg·kg-1的Ce和Nd对小鼠性腺激素的分泌有明显的抑制作用,以 2 0 0和80 0mg·-1的Ce随饲料摄入对雄性小鼠精子畸形率明显升高。

The fatter mice in Gewirtz's study had been bred to lack a protein known as toll-like receptor 5 (TLR5), which most intestinal cells sprout on their surface. Its job is to recognize and bind to the whiplike flagella that bacteria use to move around. TLR5 acts as a traffic cop for controlling the mass of pathogens living in the intestine; without it, the normally harmless gut bacteria tend to overflourish and expand in number. See and listen to an audio slideshow about obesity rehab.

Gewirtz 实验中的胖小鼠普遍缺乏一种被称之为 toll 样受体5 (TLR5)的蛋白,这种蛋白是肠上皮细胞表面分泌的, TLR5的作用是识别并结合在肠道细菌的运动器官鞭毛上,在对大多数肠道病原体的控制中, TLR5扮演着交通警察的角色,没有它,一般无害的肠道菌就会异常活跃并且大量繁殖。

These results suggest that the activate spleen-energy method can achieve appetitive purpose by not only affecting the gastrointestinal tract function in periphery, but also regulating the process of ingestion in brain. The basic research about ingestion indicate: one hand, after food enters the gastro-intestinal tract, the endocrine cell of the intestinal tract is activated and secrete many kinds of brains intestines peptide, the level of the brain intestines peptide in blood as the periphery signal spreads to the central nervous system regions that control digest and feeding behavior. On the other hand, it has been shown that dorsal parabranchial neurons, containing CCK-8S, extend fibers to the VMH and are involved in the inhibition of feeding .

关于摄食控制的基础研究表明,一方面食物进入胃肠道后,激活肠道的内分泌细胞,分泌多种脑肠肽如CCK-8S,这些脑肠肽在血中的水平作为外周信号可通过&肠—脑轴&传入中枢神经系统介导消化和摄食行为的部位,影响摄食中枢神经元的活动调节动物的摄食行为;另一方面中枢神经元可合成释放内源性的神经肽直接作用于摄食中枢神经元调节摄食,如中枢鳃旁体神经元的神经纤维就可延伸到达VMH,并且合成释放内源性的CCK-8S。

Therefore with the match of Pre-Tang names of the five notes of the pentatonic scale corresponding roughly to do re mi sol la with the relations between the five elements including Wood, Fire, Earth, Metal, and Water and the function of organs, ideology of body function adjustment and clinical experience from the psychological experts, we specially designed some music with the Yu note to cause brain wave from the body through the transfer of music to decrease the volume of anterior lobe Adrenocorticotropic Hormone, regulate the performance of autonomic nerve and improve the activity of metabolism.

为此,我们根据中医学界提出运用五音配以五行与人体的脏腑功能相联系,以调整人体功能的理念,同时结合心理专家的临床经验,专门编辑了一些羽调式的乐曲,利用音乐的传递,使人体产生脑波,以减低脑垂体前叶促肾上腺素的分泌量,调节身体的自律神经能力,达到提高新陈代谢活动性的作用。

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