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Objective: To investigate the biological effect and function mechanism of sodium arsenite (NaAsO2) and sodium fluoride in human lymphocyte in vitro and provide the basis for further study.

目的:观察氟、砷单独及联合作用对正常人淋巴细胞的增殖及IL2分泌情况,为探讨氟、砷单独及联合作用对机体免疫功能的影响规律及其作用机制提供科学依据。

It regulates the formation of gameter and hormonic function through secreting as a pulse model from the hypothalamus and combining with a specific receptor named GnRH receptor in pituitary anterior to stimulate the secretion of LH and FSH.

在垂体前叶内,GnRH作用于促性腺激素分泌细胞特异性的GnRH受体,通过受体的介导,刺激LH和FSH的分泌,从而调节性腺内配子形成和激素功能。

Methods: Affinity chromatography was used to purify B16 HACs.γ-IFN and IL-2 secreting activities were determined with crystal voilet staining and lymphoblast proliferation induced by Con A, respectively. Pecific CTL killing rate was detemined with 3H-TdR incorporation.

CNBrSepharose 4B亲和层析法提纯B16HACs,应用体内免疫法检测HAC的抑瘤作用,结晶紫染色法检测γIFN分泌活性,ConA诱导的淋巴母细胞增殖法检测IL2分泌活性,3HTdR掺入法检测特异性CTL的杀伤活性。

Acne is caused due to excessive sebaceous gland secretion and therefore the entire body fat reduction in sebum secretion can play some role but the effect is not significant.

青春痘是由于皮脂腺分泌过剩造成的,因此全身的去脂可以对皮脂分泌的减少起到一些作用,但效果不会明显。

As we know that human placentalsyncytiotrophoblast cell derlves from the fused cytotrophoblast cell and fetal calfserum can be able to induce the term placental cytotrophoblast cell fusion in vitro.

妊娠过程中,合体滋养层细胞分泌的hCG可促进卵巢黄体和胎盘分泌孕酮,在维持妊娠中起着重要的作用;然而未分化的细胞滋养层细胞不能合成hCGβ。

Among the most common excretive cytokines, increasing of GRO, IL-6, IL-8 and TIMP2 might be related to drug-resistance of ADM and CBPDA in ovarian cancer cell, while IL-6 and IL-8 might also be related with drug resistance of TAXOL and VP16. The different types of ovarian cancer cell might have roughly similar excretive cytokines-induced mechanism of drug resistance.

在常见分泌型细胞因子中,GRO,IL-6,IL-8和TIMP-2升高与一线化疗药ADM和CBPDA耐药性相关,IL-6,IL-8与二线化疗药TAXOL,VP16耐药性相关,不同来源的卵巢癌细胞分泌型蛋白作用机制可能存在共同的上述几种蛋白参与的调节体系。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PHφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PMφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

The expression of Munc131 is accordant to blood insulin level and plays an essential role in insulin exocytosis.

Munc131在胰岛素释放过程中的作用,随着胚胎发育期胰岛素分泌的增多表达也增加,宫内发育迟缓新生大鼠胰岛素分泌减少时,Munc131的表达亦减少。

MMPs are usually secreted as latent, inactive proenzymes, which need to be activated (Fig 1 ), and/or are bound to their native inhibitors, the tissue inhibitors of metalloproteinases.8 Activation may involve proteolysis and/or oxidation of the latent enzyme.8 Proteolytic activation of the proenzymes cleaves the propeptide sequence, which masks the active site of the latent enzyme.

金属蛋白酶常以无活性的酶原方式分泌,而后者要么需要被激活要么与附近的或组织中金属蛋白酶抑制物结合。激活作用包括了具有潜在酶的蛋白水解作用或氧化作用。酶原的蛋白水解激活作用能将掩盖活性部位的潜在酶的前肽序列破坏。

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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。

Only person height weeds and the fierce looks stone idles were there.

只有半人深的荒草和龇牙咧嘴的神像。

This dramatic range, steeper than the Himalayas, is the upturned rim of the eastern edge of Tibet, a plateau that has risen to 5 km in response to the slow but un stoppable collision of India with Asia that began about 55 million years ago and which continues unabated today.

这一引人注目的地域范围,比喜马拉雅山更加陡峭,是处于西藏东部边缘的朝上翻的边框地带。响应启始于约5500万年前的、缓慢的但却不可阻挡的印度与亚洲地壳板块碰撞,高原已上升至五千米,这种碰撞持续至今,毫无衰退。