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Among the most common excretive cytokines, increasing of GRO, IL-6, IL-8 and TIMP2 might be related to drug-resistance of ADM and CBPDA in ovarian cancer cell, while IL-6 and IL-8 might also be related with drug resistance of TAXOL and VP16. The different types of ovarian cancer cell might have roughly similar excretive cytokines-induced mechanism of drug resistance.

在常见分泌型细胞因子中,GRO,IL-6,IL-8和TIMP-2升高与一线化疗药ADM和CBPDA耐药性相关,IL-6,IL-8与二线化疗药TAXOL,VP16耐药性相关,不同来源的卵巢癌细胞分泌型蛋白作用机制可能存在共同的上述几种蛋白参与的调节体系。

These transgenic cells were able to secrete hEGF protein to certain extent, and have the biological activities to enhance the growth rate of Hacat cells in vitro. Conclusion: Adult epidermal keratinocytes in vitro transfected with exogenetic hEGF cDNA can express and secrete active hEGF.

质粒pcDNA3.1-hEGF在脂质体介导下成功转染成人皮肤角质形成细胞,转基因细胞能分泌有生物活性的EGF;体外培养的成人皮肤角质形成细胞可见少量EGF分泌

After finish the digestion, then flow back to the blood.also, during the period of liver and gallbladder concertrate in the hepatoenteral circulation,the bile acid can drain massively with the excrement.and more seriously after adding the fat feed stuff.if this condition go on, the fat cannot be absorbed in time and the energy will be wasted and cause some disease and etc.but after adding the appropriate exogenetic emulsifier,the question can be solved.

作为正常的机体,胆汁酸由肝脏分泌,进入肠道,在完成消化,回流入血液,又在肝脏和胆囊重新富集的肝肠循环的过程中,会经过粪便大量流失。在脂肪含量较高的饲料配方下,流失更为严重。日肝脏分泌量不足弥补流失量,会造成脂肪消化的阻滞,能量的浪费,且易诱发肝胆代谢紊乱等各种疾病。得不到消化吸收的油脂,在肠道内被噬油微生物降解,使噬油微生物类群大量增殖,打破原来肠道内微生态平衡,产生腹泻等菌群失调症,以上的问题,都是由于脂肪乳化作用不足和脂肪代谢失调造成的。在补充了合适本物种须求的外源性乳化剂后,问题可得到解决。

In addition, your baby's mouth small and shallow, swallowing reflex function is not perfect, will not be used to regulate the movements of swallowing saliva, so when the little saliva or baby happy, laugh and play, you may be unable to secrete saliva from All swallowing it, and diffuse over embankment, the outflow of extraoral.

再加上宝宝的口腔小而浅,吞咽反射功能还不健全,不会用吞咽动作来调节口水,所以当唾液分泌稍多或是宝宝高兴、嬉笑时,可能就会因无法将分泌出来的口水全部吞咽下去,而漫过大堤,流出口外。

LH may be involved in the functional regulation of fundic glands through autocrine or paracrine activity.

大鼠胃壁细胞和胃主细胞既能产生LH,又能表达LHR,说明LH对胃壁细胞和胃主细胞功能作用可能是通过旁分泌或自分泌的作用来实现的。

Many studies reported suggest both neuronal precursor cells before innervation of target fields and the neurons of adult animal coexpress neurotrophic factors and their receptors, implying that autocrine and paracrine modes of NTFs exit. It has been observed that a number of neurotrophic factors and their receptors were expressed in cultured hippocampal cells and dorsal root ganglionic cells.

研究表明,无论是靶组织联系建立以前的神经元前体细胞,还是成年后的神经元,均有神经营养因子与其受体的共同表达,提示有神经营养因子自分泌和旁分泌存在的可能性。

Three donor wheat all show good character and had little genotypical difference in the aspect of inducement、differentiation、regeneration etc. They could all nice genotypical cultivars for wheat transformation. 3160 embryos have been used to transformation (960 embryos belongs to Atlas66, 1000 embryos belongs to EM12, 1200 embryos belongs to Scout66 respectively), At last, we got twenty-six of which were positive cultivars through PCR. The preliminary whole transformation frequency was 0.82 percent. Also the citrate synthase activities of the leaves of T_0 progeny show 5~9 higher than the control lines.

转化过程中分别使用了960个Atlas66、1000个EM12和1200个Scout 66幼胚(总记3160个),经抗性筛选、CS与标记基因的PCR检测初步表明有26株为阳性植株,总转化率为0.82%;同时进一步对T_0代植株叶片柠檬酸合酶以及T_1代植株经铝胁迫后对其根尖分泌物进行检测,结果在上述转化植株中检测到了柠檬酸合酶的活性,且转化材料比对照材料平均高出了5~9倍;同时铝胁迫后,T_1植株根尖检测到了苹果酸及柠檬酸的分泌

The level is higher in the breeding time than in the non-breeding time. The change of T level is significantly correlated with the breeding season. The change of T level of the male Equus hemionus is significantly correlated with the seasonal change of a lot of breeding behaviors, illustrating that the breeding behavior of the male Equus hemionus is regulated by the T secreted by the testis.

雄性蒙古野驴的T变化水平与很多繁殖行为的季节性变化显著相关,说明雄性蒙古野驴的繁殖行为是受精巢分泌的T调节的,T分泌的季节性波动是雄性蒙古野驴繁殖行为季节性变化的生理基础。

A diverse range of effects:on protein solubility and secretion was observed,and these effects were highly dependent on the particular chaperone.In the host strain over-expressing chaperone SecB harboroing pSecB,the amount of total periplasmic proteins was increased by about 71%and the activities of alkaline phosphatseand GL-7-ACA acylase(GL7A)were increased by about 54%and l.5-fold respectively.In the host strain over-expressing chaperone GroEL bearing pGroEL,the amount of total periplasmic proteins was increased by 52%,and the activity of penicillin G acylasewas in creased by about 76%;about 90%of Hexameric Calcitonin(Cal6)inclusion body and l5%of MS2interleukin3(MS2-HIL3)inclusion body became soluble respectively.All the data were compared with the parental strains un-bearing plasmdis pSecB or pGroEL.

在过量表达SecB的宿主菌中,周质空间分泌蛋白总量较对照组提高了约71%,GL-7-ACA酰化酶在周质空间酶的活力较对照组提高了约1.5倍,碱性磷酸酯酶在周质空间酶的活力较对照组提高了约54%;在过量表达GroEL的宿主菌中,周质分泌蛋白总量较对照组提高了约52%,青霉素G酰化在周质空间酶的活力较对照组提高了约76%,鲑鱼降钙素六聚体的可落性组分的比例由原来的45%增加到约90%,而MS2-人白介素-3融合蛋白的包涵体有约15%转变为可溶性组份。

Then the tissue and blood samples were obtained and measured.Result: In the muscovite group,restored mucosa thickness increased,cystically dilated glands decreased,microvessels in connective tissue increased,the secretion of mucus,hexosamine, PGE2,EGF,bFGF were enhanced,and the express of EGFR was stronger.

结果:经云母治疗后,大鼠再生黏膜厚度增加、囊状扩张腺体数目减少,肉芽组织炎症细胞浸润数量减少、微血管数量增加、胶原面积增加,黏膜中性黏液和氨基己糖分泌增多,血浆PGE2,EGF分泌增多,免疫组化染色中黏膜局部EGFR,bFGF阳性细胞表达增强。

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