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PART 2:The molecular mechanisms of Nontypeable Haemophilus influenzae induced inflammatory response in respiratory epithelial cells Objective:Nontypeable Haemophilus influenzaewas traditionally considered as an extracellular pathogen in respiratory infections.In this study,we established a model of infected cells to confirm NTHI was also a facultatively intracellular pathogen.Mitogen activated protein kinasesare the important signal transduction pathway in mediating inflammatory response induced by NTHI in respiratory epithelium.In this study,we elucidate the impact of NTHI,and its SCF and EP on the expression of MAPK and subsequent proinflammatory mediators.

第二部分:NTHI致呼吸道上皮细胞炎症反应的分子机制研究目的:通过建立呼吸道上皮细胞株的体外NTHI感染模型,确认NTHI在细胞内的存活,观察NTHI及其组分(可溶性胞质成分SCF、外膜蛋白EP)对呼吸道上皮细胞MAPK信号传导通路和后续的前炎症因子表达的影响,并应用特异性ERK-MAPK抑制剂U0126、p38 MAPK抑制剂SB203580特异性阻断下游MAPK信号传导通路,观察它们对呼吸道上皮细胞分泌前炎症因子表达的影响。

NaCl and iso-osmotic PEG had inhibitory effect on the germination of two halophytic seeds, and the inhibitory level of PEG was greater than that of iso-osmotic NaCl. Inhibitory effects of NaCl and water stress mainly showed lowering the seed germination rate, delaying initial time of seed germination and extending the time of seed germination.

本研究从生理和分子角度对其耐盐性进行了初步的探讨,开展这两种盐生植物耐盐相关基因的克隆及盐爪爪液泡膜上多个耐盐相关基因的遗传工程,为作物和林木的遗传改良奠定坚实的理论和实验基础。

Pius the appropriate transient high-voltage pulse to the human skin,one temporary reversible hydrophile channels can be formed in the dual-layer Lipid membrane, it can accelerate active components to infiltrate perfectly.

用一个瞬态脉冲技术,将适当的瞬态高电压脉冲加在人体皮肤上,便可在细胞膜等脂质双分子层形成暂时的可逆的亲水性通道,从而增加细胞及组织膜的渗透性,对活性成分达到理想的促渗效果。

Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection.

加拿大蒙特利尔大学和美国佛罗里达免疫和基因治疗研究所的科学家合作进行的研究发现,膜蛋白PD-1和细胞衍生因子IL-10这两种分子联手作用,影响了艾滋病病人体内的CD4T细胞发挥正常作用,从而导致患者免疫系统受损并加快了患者病情的发展。

The chapter four has successfully synthesized NaA zeolite membranes with highly intergrown crystals on seeded SiO〓 modifying α-Al〓O〓 composite substrate.

在25℃和0.1MPa的压差条件下,经24h合成的膜的完整性最好,H〓/N〓,H〓/CO和〓的理想选择性分别达到7.33,10.11和18.24,显著高于相应的努森扩散值3.74,3.74和4.69,表明大部分气体分子是在分子筛孔道中进行扩散。

A new selective electrode based on nefopam- iodomercurate molecular association complex is reported.

报道一种以平痛新与碘汞酸盐形成的分子缔合物为电活性物的新型PVC膜平痛新离子选择电极。

Only Lamin A was observed to be able to be co-immunoprecipitated with 8B7 spectrin.Lamin A is a component in lamin and functions as a common anchoring site for many proteins.It plays important roles in maintaining normal morphology of nuclear envelope,presenting anchoring site for chromatin and reconstructing of nucleus.8B7 spectrin may function through interaction with Lamin A.

Lamin A是核纤层的组成成分,由LMNA基因编码,是核内许多蛋白分子的共同锚定物,在维持核膜的正常形态,提供染色质的锚定位点以及在核的重组过程中可能发挥重要作用。8B7血影蛋白可能经由Lamin A发挥功能。

The technology of refining α-linolenic acid by wiped film molecular distillation has been studied.

本文应用刮膜式分子蒸馏装置对α-亚麻酸的提纯进行了研究。

This is one kind by the neutral distilled water the bamboo coal factor which for the carrier, auxiliary purifies and essential becomes the membrane assistant, to seal the solid anti-alkali member contour molecular compound naturally to undergo a series of complex craft purification to become, this green environmental protection, can form compact protective film fast on the wall surface, has the stable wall surface, waterproof, the anti-alkali function, can prevent the wallpaper mildewy deterioration effectively, the enhancement wallpaper and the wall coheres the strength, is advantageous in the wallpaper construction, the extension wallpaper service life.

本品是一种以中性蒸馏水为载体、辅以精制的竹炭因子和必要的天然成膜助剂、封固抗碱分子等高分子化合物经过一系列复杂的工艺精制而成,本品绿色环保,能快速在墙面上形成一层致密的保护膜,具有稳定墙面,防水、抗碱的作用,能有效防止壁纸发霉变质,增强壁纸与墙体黏结力,有利于壁纸施工,延长壁纸的使用年限。

And then through the delivery of Intermolecular energy, so that the aggregate of pre-polymers and micropatterns monosomic, and so on polymer become excited state, producing charge transfer collateral fitness; complexiometric inpurity, cross-linked frame constantly curing membrane.

然后通过分子间能量的传递,使聚合性预聚物和感光性单体等高分子变成激发态,产生电荷转移络合体;络合休不断交联架台、固化成膜。

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