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Nevertheless, no homologues of typical molecular chaperones have so far been found in periplasm, and the recently reported chaperone activities of periplasmic protein disulfide isomerase and peptidyl pro-lyl isomerase seem to be too weak to satisfy such assumed needs.

虽然膜间质中的蛋白二硫键异构酶和脯氨酸顺反异构酶最近被报导具有分子伴侣活性,但是这种活性的检测使用的不是天然的膜间质蛋白,而且没有捕获到复合物的形成,因此看起来仍不能够满足前面分析的对膜间质蛋白保护的需求。

Methods Based on the index related to protopine, to investigate the effect of different aperture membrane and orthogonal test of separation parameters on membrane separation efficiency of Xiatianwu Injection.

采用不同截留分子的膜组件、操作参数进行正交设计,以与原阿片碱相关的各种指标考察不同膜组件及操作参数对膜分离效果的影响。

EXPERIMENT 1 Objective To study the regularity of the injury of the mice learning and memory ability, after the whole brain irradiation. Method After anaesthetized with thiopentone, the whole brain of Kunming mice was irradiated with 10MeV electron beam. Mouse learning and memory ability were measured with step down method on the first, second, third, fourth, fifth, fourteenth, twenty-eighth, fifty-sixth and eighty-fourth day after the irradiation.

随着现代放疗技术及计算机、分子生物学等相关学科的快速发展,肿瘤疗效逐步提高,脑等晚反应组织的放射损伤越来越受重视,因而有必要采用动物实验及分子病理学手段,深入研究放射性脑损伤的发病机理和早期症状,以及活血化瘀中药的防治作用,为此我们设计并完成了学习记忆力放射损伤规律、脑室管膜下区细胞凋亡及相关基因表达、中药防治放射性脑损伤及分子机理三个实验,介绍如下:实验一目的研究照射后鼠学习记忆力损伤变化规律。

Molecular orientation of copper phthalocyanine LB films was studied by polarized UV-Vis spectra, indicating that the phthalocyanine macrocycle was arranged . The existence of the nanoparticles increased the sensitivity of the composite LB films and decreased response-recovery time to alcohols.

利用LB技术成功建构了酞菁铜及其与二氧化锡复合LB膜,通过偏振紫外—可见吸收光谱证明了酞菁大环分子在LB膜中呈倾斜取向,且复合LB膜对醇类有较高的灵敏度,SnO_2超微粒子的掺杂大大降低了薄膜的响应—恢复时间。

The five prosthetic groups (FAD, [2Fe-2S], [4Fe-4S], [3Fe-4S] and heme group) required for electron transfer from succinate to ubiquinone were unambiguously assigned into the electron density map. Besides, we find there are some electron densities around the Qp pocket at the matrix side and we believe it represents the head structure of ubiquinone, which is proved by the inhibitor bound structure that 2-TTFA just locating at the Qp site. At the same time, we find there is the second 2-TTFA binding site, locating the inter-membrane side. This finding will change our knowledge about the electron transfer inside Complex II and the ubiquinone transfer between Complex II and Complex III, and endow a new role of Complex II in electron transfer chain.

除了对各个电子传递体( FAD ,[2Fe-2S],[4Fe-4S],[3Fe-4S]以及血红素分子)进行精确定位外,我们在该结构跨膜区靠近线粒体基质一端的口袋 Qp 中,发现了一些电子密度,认为是所结合的辅酶 Q 的头部结构,这一点被与抑制剂结合的复合体的结构所证明,在该结构中, 2- TTFA 恰好结合在口袋 Qp 中,同时,我们还发现了第二个2- TTFA 的结合位点,位于跨膜区靠近线粒体膜间隙一端的口袋 Qd 中,这个发现具有全新的意义,将影响人们对电子在复合物 II 中传递以及辅酶 Q 在复合物 II 与 III 之间转移的认识,促使人们重新复合物 II 在线粒体呼吸链中的角色。

Photoelectric materials with organic-inorganic hybrid perovskite structure are novel molecular-scale composites through organic and inorganic compounds self-assembling.The layered perovskite framework comprised of metal halide octahedra provides a distinct set of advantages including good electrical mobility, mechanical and thermal stability,while organic component offers a number of useful properties including structural diversity and ease of processing et al.

有机/无机杂化钙钛矿结构光电功能材料是通过有机分子与无机分子的自组装形成的一类新型的分子复合晶体材料,无机金属卤化物构成的钙钛矿结构提供了有序的载流子传输网络并提高杂化材料的机械稳定性和热稳定性,而有机组份的功能性和易加工性使杂化材料具有光电功能和大面积成膜性能。

The wear modes for solid films include the pulling-out of the molecules from the film and the resultant distraction of the film structure.

固体膜的磨损表现为分子从膜中的拔出和由此造成的膜结构的破坏。

The higher surface energy of substrate results in higher effective viscosity and thicker ordered molecular film.

从侧面证明了有序液体模型的正确性,即薄膜润滑的成膜性能与近固体表面润滑剂分子的有序度密切相关;足够大的外电压使无序流体膜有序化,生成较高的有效粘度和较厚的油膜,并且二者随着外电压的增加,逐渐趋于稳定;外电场作用下,摩擦系数增大,切断电源后,摩擦系数减小,但不能恢复到未加电压前的摩擦系数值。

Cellular adhesion molecule is a kind of glucoprotein expressed on the membrane surface of various cells,which mediate the conjunction and adhesion of cells and extracellular matrix.Vascular cellular adhesion molecule-1(VCAM-1) and intercellular adhesion molecule-1 (1CAM-1) are members of CAM.

细胞粘附分子(cellular adhesion molecule,CAM)是一类由多种细胞产生的,调节细胞和细胞间以及细胞和基质间相互结合并起粘附作用的膜表面糖蛋白,主要包括血管细胞粘附分子-1(vascular cellular adhesion molecule-1,VCAM-1)和细胞间粘附分子-1(intercellular adhesion molecule-1,ICAM-1)等。

Recently, the cDNA encoding PTA1 has been cloned from activated Jurkat cells by Sherrington and show it to be a novel member of the immunoglobulin superfamity with the unusual structure of two V domains only. This result provided a fundamental base for further study on PTA1 functions and its ligand identification.

从核苷酸推导的氨基酸序列表明PTA1由334个氨基酸组成,先导序列18个氨基酸,成熟PTA1分子为316氨基酸,胞膜外区232个氨基酸有两个Ig样结构域,属于免疫球蛋白超家族成员,胞浆区59个氨基酸中,含有3个酪氨酸,6个丝氨酸和6个苏氨酸,有PKC和PTK作用的基序,这些特征都与PTA1分子的功能密切相关,因此PTA1 cDNA克隆成功为进一步深入研究PTA1分子的作用机理奠定了坚实的基础。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。