分子性

Study on molecular characters of atagonist indicated that neonicotinoids insecticides and the active pharmaceutical group displayed electro-negative and electro-positive, and study on the interaction between atagonist and nAChR at the complex of subunit of insect and subunit of mammalian indicated that the effect of basic aminoacid in D ring of binding location of ACh is very obvious, and the YXCC in C ring of binding location also attracted the attention too.

激动剂的分子特点研究表明，新烟碱类杀虫剂和ACh药效基团在静电性上分别显示负电性和正电性。用昆虫亚基和脊椎动物亚基组成的杂合受体同激动剂相互作用的研究，主要集中在受体亚基上不同氨基酸残基与不同激动剂结合电生理效应的特点上。

To improve the yield and quality of wheat is an important project to breeder with genetic method. Wild emmer (Triticum. Dicoccoides Kom), as a close species to common wheat, has many good characteristics which can be used to improve common wheat (. T. aestivum L) and is precious material in wheat evalution.

野生二粒小麦(Triticum.dicoccoides Kom)作为与普通小麦(T.aestivum L)亲缘关系较近的一个种，具有许多优良的特性，在小麦的遗传改良中占据着重要的位置，同时，野生二粒小麦是也是研究普通小麦遗传进化的珍贵材料本研究运用SSR分子标记方法对野生二粒小麦与普通小麦的A、B染色体组的同源性进行研究；同时，为了探讨野生二粒小麦的耐盐性能否应用在普通小麦的遗传改良中，采用水培法对从以色列引进的93份野生二粒小麦的耐盐性进行了初步探讨，为普通小麦的遗传改良提供实验依据。

Wesynthesized (2E, 6E)-farnesol 12 starting from compound 24 by three steps.The optical sesquiterpenoid 14 was synthesized starting from--citronellol with a 28% overall yield, and the absolute configuration of 14 wasinfered (3R, 7S)-3, 7, 11-trimethyl-10-oxododecanoic acid on the basis of thechirality of starting material and biogenic relation.

以手性--香茅醇为原料，经七步反应也合成了旋光活性的目标分子14，结合生源关系，推测天然产物14的立体结构为(3R，7S)-3，7，11-三甲基-10 氧代-十二碳酸；对手性中间体34经脱除羰基得到手性天然产物(3R.7RS)-六氢法呢醇13。

Howerer, solid dispersion is one of the technologies of increasing the bioavailability of indissolvable drug, which force drug being at high disperdion state, Generally, drug particle diameter in solid dispersions was 0.001～0.1um, mainly dispersed condition was molecularity, metastable amorphism and colloidal state.

而固体分散体是增加难溶性药物的生物利用度的常用方法之一，其主要是使难溶性药物在水溶性载体中处于高度分散状态，一般而言，药物在固体分散体中的粒径为0.001～0.1μm，分散状态以分子状态、亚稳定态及无定形态或胶体状态多见。

Recently, it is proved that SP is also involved in pain modulation, acupuncture analgesia and immunoin- hibition. However, the role of CGRP in them is unclear Therefore, the dy- namic changes of CGRP-, SP-like immunoreactivity and expression ofα- CGRP,β-CGRP mRNAs in dorsal root ganglion and spinal cord in the arthritic rats were observed by using immunohistochemistry and in situ hybridization techniques combined with behavioral tests, respectively. Subsequently, the effects of this peoptide on the develoment of polyarthritis were investigated by intrthecal injections of CGRP and its antagonist in the rats. In addtion, GAL is a novel neuropeptide which coexists with CGRP and SP, but it may play a different role in the primary sensory system. Thus, we also observed the changes of GAL and GAL mRNA in DRG neurons and the spinal cord. The results were as follows

为此本文拟在大鼠佐剂性关节炎模型上，结合行为学测定、用免疫组织化学、原位核酸分子杂交技术观察脊髓背角及DRG中CGRP、SP、α-CGRP mRNA、β-CGRPmRNA的动态变化及电针的影响，此外，用鞘内和外周注射CGRP的工具药探讨了CGRP在佐剂性关节炎发生发展中的可能作用；甘丙肽（Galanin，GAL）也是新近发现的一个神经肽，并与CGRP和SP共存于DRG及初级传入末梢中，在神经损伤模型中脊髓CGRP、SP减少，GAL则明显增加，显示GAL与CGRP和SP的作用可能不同，因此在佐剂性关节炎模型上也同时观察了GAL和GAL mRNA的变化，实验结果如下

AFLP marker technique was used to investigate the genetic relationships between 50 accessions of maize and its wild relatives including teosinte, Tripsacum and Coix With twenty one AFLP primer combinations of PstⅠ/MseⅠ, 641 AFLP amplified bands were obtained, including 586 polymorphic bands with an average of 30 52 per primer combination and the polymorphism percentage of 91 4% Cluster analysis using UPGMA method based on the data of AFLP showed that the 50 materials could be divided into...

用AFLP分子标记技术对 5 0个有代表性的玉米及其野生近缘种大刍草、摩擦禾、薏苡材料进行了遗传关系分析。利用 2 1个PstⅠ MseⅠ引物组合检出可辨认带共 6 4 1条，其中多态性带 5 86条，平均每对引物得到 30 5 2条多态性带，多态性 91 4 %。聚类分析结果表明，可以将 5 0个材料分为 3大类，与已有的玉米族分类一致，但与玉蜀黍属内的种间和种内分类存在差异，说明大刍草各种内存在较大的遗传多样性。本实验发现玉蜀黍属与摩擦禾关系比与薏苡的关系更近，但并没有发现玉米与小颖玉米亚种比与其他大刍草的遗传关系更近。

Fluorescence, UV-vis and NMR are the most common methods in the research of chiral recognition. According to these methods, the latest research progress in the synthesis of chiral receptors based on calix[4]arenes and their applications in the chiral recognition are summarized.

在手性识别的研究中，荧光、紫外和核磁是3种最常见的研究方法，本文根据这3种方法进行分类，综述了近年来以杯[4]芳烃为分子骨架的手性受体的合成及其在手性识别中的应用。

In chapter 1, the background of the development and formation mechanism of chiral supermolecules assembly, chiral mesoporous materials and chiral conducing polymers, have been detailedly elaborated.

第一章中，简单介绍了手性超分子体的发展及其形成机理，综述了手性介孔材料以及手性导电高分子材料的合成、形成机理以及最新研究进展，并对本文工作的背景进行了详细的阐述。

The results showed that the conidia of the RNAi transformant accumulated more trehalose, lost viability more slowly during prolonged storage and showed reduced heat shock sensitivity than the wild type, and the overexpression transformant has reverse results. These results indicate that neutral trehalase in M.anisopliae control trehalose concentration via degradation of trehalose, and indirectly influnce the viability of conidia during prolonged storage and the resistance to heat stress.

以上研究结果表明，金龟子绿僵菌CQMa102孢子体内海藻糖是由中性海藻糖酶降解的，海藻糖含量与耐储性和耐热性具有正相关性，中性海藻糖酶在虫生真菌金龟子绿僵菌孢子中的生理功能是通过降解分子内海藻糖调控海藻糖含量，从而影响其对不良环境的抗性，如储藏性、耐热性。

Furthermore, preliminary work also performed to examine whether PI3K/AKT signal transduction pathway was activated in the process of refractory leukemia development. Materials and methods An immortalized human bone marrow stromal cell line, HS-5, was introduced to establish a bi-phase culture system for the cultivation of B-lineage precursor leukemia cells. ELISA and RT-PCR were used to investigate the expression of VEGF and its receptors in the leukemia cell lines and primary childhood leukemia cells in different treated groups. Flow cytometory method and immunofluorescent staining were employed to examine the apoptosis signals both in the VP16 treated and untreated leukemia cells. Western blot was utilized to explore the PI3K/AKT activated status in the drug induced or uninduced leukemia cells and lymphocytes from healthy donors.

材料和方法使用来源于人类骨髓基质细胞的细胞株HS-5作为滋养层细胞进行急性淋巴细胞性白血病细胞的体外培养，通过细胞生物学和免疫学方法评估培养体系并鉴定出难治性白血病细胞克隆；以ELISA和RT-PCR方法检测急性白血病细胞株和患儿白血病细胞VEGF及其受体的表达，了解不同治疗阶段VEGF及其受体的表达状况，并结合临床指标进行分析，明确VEGF及其受体在白血病发生过程中的作用；流式细胞仪和免疫荧光染色法对正常健康儿童、初发白血病患儿、复发白血病患儿及缓解后患儿进行凋亡因子检测和分析，初步阐明难治性白血病抗凋亡形成的原因；蛋白印记分析检测PI3K/AKT信号传导通路在健康儿童、初发白血病和复发白血病患儿的表达，初步了解难治性白血病形成的分子生物学机制。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。