分子性

Hypericin belongs to the amphiphile molecule. However, it is very lipophilic and water-insoluble.

金丝桃素属於双性分子，然而本身具亲脂性不溶於水。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

A series of novel aromatic amide molecular tweezers with different chiral centers and cavities were designed and synthesized by using isophthalic acid as the spacer to bridge the different L-amino acid methyl esters under microwave irradiation.

以间苯二甲酸为隔离基，酰胺键桥联L-氨基酸甲酯构成手臂，在微波辐射下合成了具有不同手性中心和裂穴的新型手性芳酰胺类分子钳。

The genomic DNA of 42 accessions of leucaena were amplified by using 3 pairs of AFLP primers: E-ACC/M-CTC, E-ACG/M-CTT, E-ACC/M-CAA, and 125 clear bands were produced, of which 108 were polymorphic.

其中17条带为所有材料共有，占14.29%，108条为多态性带，平均多态性百分比为85.71%，从DNA分子水平显示出银合欢具有丰富的遗传多样性。

Mellifera ,with 91% amino acid identity.

同时根据氨基酸序列用GENETYX程序绘制了 7种Hya的分子系统树，并根据同源性比较分析了 7种Hya的保守性、结构与功能的关系

All of the neurotherapeutics that are used in clinical practice at present are small lipid soluble molecules that can diffuse through the BBB. Yet these drugs can no longer meet the clinical needs, many brain neurotherapeutics and neuroprotective drugs are large, water soluble molecules.

临床上采用的中枢神经系统药物大多是能够扩散通过血脑屏障的小分子脂溶性物质，而这类药物已经远远不能满足临床需要，很多疾病的诊断、治疗需要大分子、水溶性物质。

Results Many neuronal cell bodies and fibers with dense mGluR7-like immunoreactivity were intensely distributed in the island of Calleja,hippocampus,dentate gyrus,medial habenular nucleus,olivary pretectal nucleus,zonal layer of the superior colliculus,superficial layers of the caudal spinal trigeminal nucleus,paratrigeminal nucleus,raphe magnus nucleus,raphe nucleus pallidus,locus coeruleus,superficial layers and lateral spinal nucleus of the spinal cord.

近年来，大量生理学和药理学实验表明，Glu还可通过与G蛋白偶联的一类受体来调节兴奋性突触的活动和神经元的兴奋性，此类受体被命名为代谢型谷氨酸受体(metabotropic glutamate receptors，mGluRs)。目前应用分子生物学技术已成功地克隆出mGluR的8种亚型(mGluR1-8)［2～7］。

A novel bis (o-aminobenzophenone) s monomer is synthesized, and is used to get three different polyquinolines containing phenylamine moiety through Frieldlander reaction. The solubilities, thermal stabilities and luminescent properties of the polymers were evaluated. All the polymers are thermal-stable, and are soluble in common organic solvents. The emission of their thin film is from excimer emission.

合成了一种新型的二邻氨基二苯酮单体，通过Frieldlander反应，可以构造出不同结构的含有类三芳胺基元的发光聚喹啉，对其溶解性、热性能进行了研究，结果表明这类聚喹啉在常用有机溶剂中的溶解性有了很大提高，同时保持了聚喹啉较高的热稳定性；研究了它们在溶液态和薄膜态的紫外可见吸收光谱和荧光发射光谱，发现它们在薄膜态下的荧光发射主要来自于分子间激基复合物发射。

The design, synthesis and characterization of organic photoelectrical molecules have become an active and interesting subject.

同无机光电材料相比，有机光电材料有更好的可设计性和可裁接性，因此新型有机光电功能材料的开发研究已成为人们关注的热点，设计、合成光电性能优异的有机分子是有机光电功能材料开发研究中的重要组成部分。

We screened a set of Lewis base organocatalysts derived from chiral pipecolinic acid and tert-butanesulfinamide for the reduction of-N-Cbz-1- phenylpropenamine, including newly designed ones and some of those previously developed in our lab. However, only moderate stereoselectivities, albeit high yields were obtained.

在本课题组前期研究的基础上，我们筛选并设计了一系列以手性哌啶酸和叔丁基亚磺酰胺为母体的有机小分子路易斯碱催化剂，它们能催化三氯氢硅对-N-苄氧羰基-1-苯基丙烯胺的不对称还原，获得很高的收率和中等的对映选择性，并且具有很好的底物普适性。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。