分子性

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

Further research on pathophysiology and molecular biology is beneficial to clinical diagnosis and management of NASH.

对非酒精性脂肪性肝炎病理生理学和分子生物学发病机制的深入研究将有利于临床诊断和治疗。

The plentifulness of SSR polymorphism in silkworm genome and the differences of the polymorphism among different silkworm races indicate the advantage of SSR in the construction of silkworm DNA fingerprints and analysis of inheritance diversity, and show the foreground of application of SSR in silkworm molecular marker technology.

家蚕基因组丰富的SSR多态性和不同家蚕品种之间的SSR多态性差异，表明了SSR标记在遗传多样性分析中的优势，展示了SSR分析在家蚕品种分子标记技术中的良好应用前景。

Membrane affinity quantified by IAM and liposome/buffer systems was a more efficient predicator of α values than hydrophobicity from n-octanol/buffer system. Consequently, not only hydrophobic force but also attractive polar extra-interactions involved in the binding to IAM and liposomal membranes but not in an n-octanol phase, ascribed to the binding process within AM. The binding to ordered lipid membrane in the larger part determined drugs'binding to AM intracellular compositions, and the ordered phospholipid plasma membrane was a potential site for drugs'binding in AM.

脂质体／水系统和磷脂膜色谱所测定的膜亲和性比正辛醇／水系统的疏水性更好的预测巨噬细胞内药物的α值，因此包含在磷脂膜色谱中但并不体现在正辛醇／水系统中药物与磷脂膜之间的额外吸引性极性作用力对药物在细胞内结合有着重要贡献；药物与有序磷脂膜的结合在很大程度上决定着药物与巨噬细胞内成分的结合，有序磷脂分子膜可能是巨噬细胞内部潜在的结合部位。

The thesis is based on the above research advance. We have been trying to explore the prospection of apoE in prevention from atherosclerosis and Alzheimer's disease. The apoE gene was separated, cloned and expressed, as well as its function was studied in the thesis.

本文正是基于上述两方面的研究进展，试图探索apoE在预防治疗动脉粥样硬化及老年痴呆性疾病中的应用前景，利用分子生物学技术克隆表达人apoE基因，并对其功能进行探讨性研究。

The genetic relationship of 27 sapodilla cultivars and 4 mamey sapoae cultivars were analyzed by using fluorescent-labeled AFLP markers. A total of 1131 AFLP markers between 75 to 500 base pairs were generated with 9 primer combinations, of which 1096 (96.9%) were polymorphic.

利用荧光AFLP分子标记技术对27个人心果品种及4个蔓妹人心果品种资源的亲缘关系进行研究。9对引物共扩增得到1131条带(75~500 bp)，其中多态性带1096条(96.90%)。28个品种具特征性条带，特征带大小为350~500 bp。

Factor of 1 nerve nutrition and lack gene of nutrition of ill nerve of blood-vessel of head of courage and uprightness is a group of special protein and peptide kind element, this are familial include nerve to grow factor (factor of nutrition of nerve of sex of NGF), head source , nerve - 3, alkalescent grow into fiber cell factor and nerve of sex of colloid cell source.

现将几种重要的非炎性细胞因子和缺血性脑血管病关系的探究进展作以下综述。1神经营养因子和缺血性脑血管病神经营养因子是一组非凡的蛋白质和肽类分子，该家族包括神经生长因子、脑源性神经营养因子、神经营养素-3、碱性成纤维细胞生长因子和胶质细胞源性神经营养因子等。

In screens 20 from 100 10bp along with the machine-drawn to increase the effect to direct the thing well to carry on increases, altogether has 188 bandings,118 are the polymorphism belt, accounts for 62.8%, average each DNA polymorphism belt number which directs the thing to increase is 5.90, has promulgated the sweet potato variety heredity multiplicity; construct the shape chart called UPGMA to reflection variety diverse , will supply to try 31 variety divisions will be 4 broad headings, has promulgated between Hunan sweet potato variety from the molecular level and with the foreign country variety between sibship.

从100个10bp的随机引物中筛选出20个扩增效果较好的引物进行扩增，共产生188条带，其中118条为多态性带，占 62.8%，平均每个引物扩增出的DNA多态性带数为 5.90条，揭示了甘薯品种的遗传多样性；根据扩增结果构建出反映品种多样的UPGMA聚状图，将供试31个品种划分为4大类，从分子水平上揭示了湖南甘薯品种之间及其与外域品种之间的亲缘关系。

Ofeffective 1st branches, length of main inflorenscence, effective siliques of maininflorenscence, density of main inflorenscence, length of silique, seed per sillique,1000 seed weight, total effective siliques per plant had significant positive correlationwith yield per plant. Polymorphisms between zhongshuang No.4 and H228 was examined by SSR primers. 152 primers Showed polymorphisms, and a linkage map containing 123markers, including 18 linkage groups was constructed. The total genetic distance ofthe map was 3483.1cM, and the average distance of two adjacent markers was28.32cM.

选用SSR引物对中双4号和H228间进行多态性检测，有152对引物在双亲间表现多态性，用这些引物分别对142个株系进行检测，构建了含有123个SSR分子标记、18个连锁群的连锁遗传图，总图距为3483.1cM，标记间平均距离为28.32cM，各标记在18个连锁群上的分布很不均匀，其中，第1、12、13、17连锁群上分布标记较多，其它连锁群上分布标记较少。

A similar initiator, Et_2Zn/-Sparteine, yielded polys with threo-diisotactic -rich structure in the main chain, indicative of strongly asymmetric inducation in this system. In this case, no polymeric complexes in-site formed because of the intensive coordination between sparteine and Zn ions.The binary initiating system composed of Et_2Zn and n-BuLi combined the advantages of both metal alkyls, which gave the polymers with higher molecular weights and moderate optical activity ~(25_D =-97.1°～+24.3°.

Et_2Zn／n-BuLi二元引发体系综合了两种金属烷基化物的优点，得到了分子量相对较高(M_n=1.4x10~3～4.9×10~3)且含有手性超分子结构的光学活性聚合物；聚合物中锌含量的微小变化可引起聚合物光学活性明显改变，超分子手性与聚合物侧基的绝对构型存在关联。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。