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Hspa5 belongs to a member of the Hsp70 family. It plays important roles in facilitating fold and assembly of newly synthesized proteins and their translocation across the endoplasmic reticulum membrane as a molecular chaperone, helping refold stress-denatured soluble proteins and regulating signal transduction pathways by modulating the stability and activity of protein kinases and transcriptional factors.

Hspa5为Hsp70家族的成员,它可以作为分子伴侣促进新合成蛋白质的折叠、组装及其跨过内质网膜的转运;使应激变性的可溶性蛋白质重新折叠;通过调节蛋白激酶或转录因子的活性而控制信号转导途径。

The enemy Vietcong made each person count. After saturation American bombing in 1965, Mr McNamara found they were still getting 200 tons of supplies a day along the Ho Chi Minh trail, and had scattered the country with a secret stash of oil in hundreds of 55-gallon drums. The importance of tiny peasant efforts to the health of a nation struck him again when, from 1968-81, he headed the World Bank, shifting its focus and its money to rural development.

而敌方的越共却将一兵一卒都派上了用场。1965年,美军的饱和轰炸完成以后,麦克纳马拉发现越共分子仍然在胡志明小道一带获得每日200吨的补给品,并在全国范围内秘密布藏着数百只容量为55加仑的油桶。1968-81年担任世界银行行长期间,他再次猛然意识到小农的贡献对整个国家健康发展的重要性,遂将工作重点和资金转到农村发展上。

The results obtained by electron microscopic observation show that the supercoiled pUC18 DNA adopts a doughnut-like solenoidal structure with outside diameter about 43.8 nm and inside diameter about 2.0 nm in ammonium acetate-H2O medium.

观察结果显示:在疏水性的甲酰胺-水展开系统中,DNA采取通常的互缠式结构;在含有1.5 mmol/L醋酸铵的水介质中制备的超螺旋DNA标本,DNA采取线圈型结构,测得pUC18 DNA分子这种结构的外直径约为43.8 nm,内直径约为2 nm。

There are a lot of abstract concepts such as the internal rotation and the normal vibration in the statistical thermodynamics.

统计热力学是物理化学理论框架中的一个重要部分,其中有许多抽象的概念和过程很难用传统的教学方法描述清楚,多原子分子的内旋转和简正振动就是突出的例子。

Virus hasn't cell construction. A lot of simple virus is only made of nucleus acid and protein tegument, so we can regard it as nucleoprotein. A type of virus pill usual has a kind of nucleus acid. After virus infect sensitive host cell, the nucleus acid of virus will enter cell and produce its descendant and new protein by reproduction and expression. Then, the new synthetic virus is made up of descendant that release form cell by regular way. This specific way of reproduction of virus called reproduction.

病毒不具有细胞结构,一些简单的病毒又由核酸和蛋白质构成,故可把它们视为核酸蛋白分子,一种病毒的毒粒内通常只含有一种核酸,病毒感染敏感宿主细胞后,病毒核酸进入细胞,通过其复制与表达产生子代病毒基因组和新的蛋白质,然后由这些新合成的病毒组分装配成子代毒粒,并以一定的方式释放到细胞外,病毒的这种特殊繁殖方式称为复制。

In the 15th month since he ordered more US troops to Iraq President Bush says there has been a major strategic shift with many mainstream Sunnis and Shiites now actively confronting extremists. 15 months ago, al-Quida was using basis in Iraq to kill our troops and terrorise Iraqis. Today we have put al-Qaida on the defensive in Iraq.

布什说自从他要求美国向伊拉克增兵的15个月内,已经发生了重大的战略转变,许多主流逊尼派和什叶派都在积极的反对极端分子。15个月钱,基地组织利用在伊拉克的基地杀害我们的士兵并对伊拉克人民进行恐吓。

Analysis based on the experimental results demonstrated the plausible reaction mechanism is that vit C first converts Cu(superscript 2+) to its reduced state and vit C becomes vit C radical itself, thereby stimulating the formation of peroxyl and alkoxyl radicals, and bimolecular reaction of peroxyl radicals results in (superscript 1)O2 production in the systems studied.

根据实验观察的结果,分析了这一体系中(上标 1)O2形成的可能途迳,认为首先是维生素C将Cu(上标 2+)转变为还原态,而自身失去一个电子转变为维生素C自由基,从而刺激了过氧自由基和烷氧自由基的形成,过氧自由基的双分子反应很可能就是体系内(上标 1)O2产生的反应机制。

UV-Vis and continuous variation plot method were used to study the complexation of γ-cyclodextrin with bromocresol green, and the stoichiometric ratio of the complexation was to be 1∶2. Thermodynamic analysis results show an inverse relationship between temperature and complexation constant, and the change of enthalpy, entropy and free energy of the complexation were -39.988 kJ/mol, 86.400 J/ and -14.245 kJ/mol, respectively, which indicating that hydrophobic effect was the main force to form the complexes.γ-Cyclodextrin and bromocresol green complexes were examined by nuclear magnetic resonance, infrared spectrum and molecular modeling analysis, and was may be the group included in γ-cyclodextrin.

采用紫外-可见分光光度法和等摩尔连续变化法研究了γ-环糊精与溴甲酚绿的包合作用,确定了包合物形成的化学计量比为1∶2;采用热力学方法分析了温度与包合常数之间的关系,计算了包合过程的焓变、熵变及自由能变化分别为-39.988 kJ/mol, 86.400 J/和-14.245 kJ/mol,这表明疏水作用力为主要驱动力;采用核磁共振、分子模拟和红外光谱法对包合物进行了研究,确定了包合物的形成,分析认为这可能是基团进入γ-环糊精腔内导致增色效应。

METHODS: The BEC were preincubated with crocetin (1, 0.1 and 0.01 μmol/L) for 12 h, then exposed to AGE (100 mg/L). The RAGE mRNA expression was detected by RT-PCR analysis, the intercellular adhesion molecule-1(ICAM-1) was measured by ELISA. The extracellular superoxide ion and thiobarbituric acid reactive substances were assessed with superoxide ion kit and colorimetric assay, respectively The intracellular I2O2 was also detected using the probe 2,7-dichlorofluorescein. The mitochondrial membrane potential and mitochondrial Succinate dehydrogenase were analyzed by the retention of rhodamine 123 (Rh123) and MTT.

不同浓度的西红花酸(1、0.1、0.01μmol/L)预孵BEC细胞12h后,用AGE(100mg/L)刺激细胞12h,RT-PCR法测定RAGEmRNA的表达水平;ELISA法测定细胞间黏附分子-(ICAM-1)的表达;试剂盒分别检测胞外超氧阴离子和硫代巴比妥酸反应产物浓度;同时,还用2,7-二氯荧光素测定了胞内H2O2的浓度,并用罗丹明123(Rh123)荧光法及MTT法分别检测细胞线粒体膜电位水平和其琥珀酸脱氢酶的活性。

Here, we have pioneered the SINEs study in cyprinidae family based on the above questions, the results following:1 In this study, we firstly apply the inverse PCR protocol for isolating the SINEs from Opsariichthys bidens genome on the basis of A-B PCR.

马口鱼的基因组DNA利用HaeIII酶切后,利用T4连接酶进行自环化;环化后的DNA分子在反向引物的引导下执行反向PCR,最后,一组衍生于tRNA的SINEs从马口鱼基因组内获得,并根据马口鱼的学名Opsariichthy bidens命名为Opsar。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。