分子内的

In order to develop an useful synthestic process, we have synthesized amides with various substitutents. The isoquinoline skeleton was constructed through Bischler-Napieralski reaction, followed by asymmetric reduction of the imine intermediates with a Ru complex to form the only chiral center. Finally, we connected the two phenyl groups by Heck reaction and effectively obtained optically active aporphine alkaloids.

为了发展一套实用的合成方法，我们首先制备於苯环上具有不同种取代基的苯乙醯胺，接著透过Bischler-Napieralski反应进行分子内合环，并利用钌金属对亚胺中间体进行不对称的还原反应，建立出产物中唯一的光学活性中心，最后再利用Heck反应连结两个苯环，就可以顺利得到具有光学选择性的阿朴吩类天然物。

Genetic diversity of Croomia The results of inter-simple sequence repeat indicated that the genetic diversity of Croomia was very low. At the population level, the genetic diversity of C. japonica PPB = 21.20%, H_(pop= 0.0644, I = 0.0981, N_e=1.1077 was lower than that of C. heterosepala PPB = 29.81%, H_(pop= 0.0944, I = 0.1424, N_e=1.1613. But at the species level, the genetic diversity of C.

Croomia的遗传多样性分布格局 ISSR分子标记的研究结果显示，Croomia居群水平的遗传多样性很低，其中C.japonica的遗传多样性PPB=21.20％，H_(pop=0.0644，I=0.0981，N_e=1.1077稍低于C.heterosepala的PPB=29.81％，H_(pop=0.0944，I=0.1424，N_e=1.1613；而在物种水平上相反。C.japonica和C.heterosepala居群间的分化都明显大于居群内的分化，其居群间分化值F_分别为73.60％和54.99％。

PART 2:The molecular mechanisms of Nontypeable Haemophilus influenzae induced inflammatory response in respiratory epithelial cells Objective:Nontypeable Haemophilus influenzaewas traditionally considered as an extracellular pathogen in respiratory infections.In this study,we established a model of infected cells to confirm NTHI was also a facultatively intracellular pathogen.Mitogen activated protein kinasesare the important signal transduction pathway in mediating inflammatory response induced by NTHI in respiratory epithelium.In this study,we elucidate the impact of NTHI,and its SCF and EP on the expression of MAPK and subsequent proinflammatory mediators.

第二部分：NTHI致呼吸道上皮细胞炎症反应的分子机制研究目的：通过建立呼吸道上皮细胞株的体外NTHI感染模型，确认NTHI在细胞内的存活，观察NTHI及其组分(可溶性胞质成分SCF、外膜蛋白EP)对呼吸道上皮细胞MAPK信号传导通路和后续的前炎症因子表达的影响，并应用特异性ERK-MAPK抑制剂U0126、p38 MAPK抑制剂SB203580特异性阻断下游MAPK信号传导通路，观察它们对呼吸道上皮细胞分泌前炎症因子表达的影响。

The intramolecular hydrogen bonding can extend the ligand planarity and increase the intercalative ability of the complex to DNA. It is concluded that the torsion between the aromatic rings of ligands, due to introduction of the bulky substituent, results in the complexes only to partially or non-classically intercalate into DNA.

能够使配体平面性增大的分子内氢键的形成，有利于配体对DNA的插入作用；但是，由大体积的取代基所引起的配体芳环间的扭转，致使配体只能&部分地&或&非经典地&插入DNA碱基对。

In the same time, the intra-molecular photoinduced electron transfer process between naphthyl group and nitrogen atom of tertiary amine group at the tip of molecule was found and this process strongly depends on the acidity of solution.

通过对该类化合物在溶液中的光物理行为以及酸度影响的比较研究，观察到以叔胺为骨架的三足化合物存在分子内光诱导电子转移，且这一过程强烈地依赖于介质的pH值；叔胺基的氮原子质子化将会减弱这一PET过程。

TheMn complexes with internal quaternary ammonium and/or pyridinium salt, either formed in-situ or isolated, displayedsignificantly higher activities than analogous complexes and Jacobsens catalyst in theaforementioned reaction.

通过研究发现，含有分子内季铵盐和／或吡啶盐的手性吡咯烷Mn配合物，无论是原位生成的还是分离的，都比类似的配合物以及Jacobsen催化剂的活性明显高。

In the first part, the prototropic hydroxy-oxo tautomerisms of 2 (1H)- pyridones/2-hydorxypyridines, one of the most important model systems in molecular biology, have been investigated with self-consistent reaction field method based on continuum model. The influence of the nature and position of substituent groups, the existence of intramolecular hydrogen bonding and tautomeric competition between 2-hydroxy and 4-hydroxy on the tautomeric equilibria have also been examined.

第一部分，首先从溶剂敏感的异构化性质入手，用基于连续介质的自洽反应场理论方法对一类重要的生化模型体系—2（1H）-吡啶酮／2-羟基吡啶互变异构体系进行了研究，系统地考察了取代基性质、取代基位置、分子内氢键的形成以及互变异构竞争的存在对异构化平衡的影响。

In Chapter 2, the study on PET of the donor/acceptor pair via the rigid bridge, heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14] tetradecane, is presented. By using the GMH method, the electronic coupling matrix elements between ground and excited states are predicted.

在第二章，我们研究了对七环十四烷连接儿茶酚和二氰基乙烯构建的分子内光诱导电子转移体系；考察了吸收光谱随溶剂极性变化的影响，预测了该体系的电子转移机理，并利用广义的Mulliken-Hush公式，计算了基态和各激发态之间的电子转移耦合矩阵元。

This preliminary case control study reconfirms that TWHf is a very potent herbal remedy to suppress mononuclear expressions of many inflammatory cytokines and pro-inflammatory molecules.

尽管只有少数的研究对象，本篇研究提供了在免疫致病机转上的可能证据来支持雷公藤对於僵直性脊椎炎患者周边血液单核球细胞内的许多发炎性细胞激素及其它和发炎反应有关的分子的基因表现具有强烈的抑制作用的说法。

The effect of particular saturated bridge during the course of ET and HT in rigid, covalently linked donor-bridge-acceptor dyads has captured the attention of scientists'in this field.

饱和桥在双生色团的给体-桥-受体体系的分子内电子转移和空穴转移过程中的作用一直是此领域的科学家们关注的焦点。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新