分子

Currently activities involve (1) Investigation of dye-DNA interaction by using spectroscopic methods to probe the binding sites between chromophore and DNA and to identify various DNA conformational structures, particularly the telomeric DNA;(2) Investigation of the structure-activity correlation of anti-telomerase agents;(3) Design and synthesis new compounds for antitumor agents and fluorescence biomarkers;(4) Monitoring the folding and unfolding of quadruplex structure, tracing the pathway of drug delivery and probing drug-target interaction by using single molecule microscopy and spectroscopy.

目前 的研究重点分别是(1)利用光谱方法探讨探针分子与DNA的交互作用，特别是作用位置与结构变化；(2)研究抗端粒酵素作用分子之结构与生物活性之关系；(3)设计及合成抗肿瘤药剂或萤光生物标记；(4)建立单分子萤光光谱与影像技术，研究 DNA的多变型结构之变化机制，监测药物输送的路径过程及其在细胞中与标的物的作用。

Quantum chemistry method was used to calculate the geometry structure of heavy oil character molecule .

采用量子化学方法计算得到重油特征分子的几何结构，提出了用量子化学方法计算重油特征分子的最小横截面直径和描述分子尺寸的方法。

The small peptides always accomplish their configuration in the cell. Through molecular recognition, they show biology function, completely representing the diversity and cooperation among molecules.

功能短肽总是在细胞中完成其构象变化，通过分子水平上的识别效应，实现其生物功能，充分体现了分子内及分子间相互作用力的多样性和协同性。

Many landlords, rich peasants and riffraff have seized the opportunity to sneak into our Party

这即是有许多地主分子、富农分子和流氓分子乘机混进了我们的党。

The influencing factors that glutathione molecular umbrella penetrates lipid bilayers with the shielded conformation were analyzed with VolSurf parameters. The results show that the major influencing factors are smaller amphiphilic moment and larger molecular rugosity of the shielded conformation, which are independent of definite hydrophobic regions of the conformation.

利用VolSurf参数分析了分子伞以屏蔽构象穿透磷脂双分子层的影响因素，结果表明屏蔽构象较小的两亲矩及较大的分子褶皱程度是其能够穿透细胞膜的主要影响因素，与构象的绝对疏水区域无关。

Scatter diagram of the morphological differential value and molecular differential value shows plants molecular differential value≥2 are heterotipe. The correlation coefficient of the morpha uniformity ratio and molecule uniformity ratio is 0.98, extreme correlation. So the heterotipe criterion of the molecular differential value≥2 is made.

通过对14个品种278个株的形态差异值和分子差异值的散点图分析，得出形态差异值≥2为异型株；由形态一致性比率和分子一致性比率的相关性系数为0.98，相关极显著，确定分子差异值≥2作为判定异型株的标准。

In the Chapter 2 of this dissertation, new pulse sequences were introduced, in which CPMG and bipolar gradient pulses have been implemented into pulsed-filed-gradients spin-echo NMR spectroscopy, and is used to measure the self-diffusion coefficient of metabolites in bio-fluids.

实验结果表明，这种新方法不仅可以在生物体温或更高温度下准确测量分子的自扩散系数，不受对流和背景梯度的干扰，同时还具有复杂核磁共振谱的编辑功能，能够在不做任何物理分离的条件下，分别研究生物大分子和小分子的扩散系数，以及分子之间的相互作用。

Tricholoma may be a paraphyletic genus two. The collections identified as T. caligatum is a mixture. Some parts of them from France are members of T. matsutake, the other parts from North America are closed to T. bakamatsutake and T. fulvocastaneum. Tricholoma robustum and T. focale form a clade which is obviously a sister group of the stirp Subannulate. The stirp Caligata was defined as a group mainly on the basis of the predominant veil. But from the result of molecular systematic analysis, the presence of veil is not a stable character in the matsutake group. Species having symbiosis with conifers and broad leaf tree are all transformed from those whose host specificity is not strict. The phylogenetic tree based on ITS sequences resembled the tree of NJ algorithm based on cladistic coding. In the phylogenetic tree based on morphylogical characters, T. zangii and T. bakamatsutake form a clade, but it is the result of convergent evolution as suggested by molecular analyses. The distribution area of the matsutake group can be divided into six regions: middle and northern Europe region, Mediterranean region, Hengduan Mount.— Southeastern Tibet region, Northeastern China—Japan—Far-east Russia region, the Atlantic—North America region and the Rocky Mountain region. The abundance center of the matsutake group are Hengduan Mount.—Southeastern Tibet region and the Rocky Mountain region. Hengduan Mount.

松口蘑群的分子系统学研究得出的结果有：由于粗壮口蘑和羽衣口蘑明显和亚环族(Tricholoma，section subannulate)的种类是来自同一个谱系，和其它松口蘑群的种不具有最近共同祖先，因此松口蘑群是一个多系群；松口蘑群和口蘑属其他种类的亲缘关系比和蜜环菌属更接近；梭柄松苞菇和松口蘑群的差距明显小于油黄口蘑(T.flavovirens)和棕灰口蘑；口蘑属是一个多系群；鉴定为欧洲口蘑的标本明显不是一个单系群，其中一部分是松口蘑，另一部分和黄褐口蘑及傻松口蘑(T.bakamatsutake)比较接近；划分松口蘑群的标准是菌环的存在，但从分子系统学的结果来看，菌环的存在与否并非是一个很稳定的性状；和针叶树专性共生及和阔叶树专性共生均由寄主专化性不强的种类转化而来；在形态学系统发育树上青冈口蘑和傻松口蘑被聚为一个分枝，分子系统学的研究结果表明，这是趋同进化的结果；用支序方法编码作出的NJ树的结果更接近ITS序列的结果。

A series of sulfanilamide group substituted derivatives were optimized on the basis of the semi-empirical quantum chemistry PM3 method.

以量子化学半经验PM3法对含磺胺基的一类有机化合物分子进行了几何构型优化，计算了分子的二阶非线性光学系数和电子转移，讨论了磺胺基在非线性光学材料设计中的特点和作用以及不同的取代基及取代位置对分子二阶非线性光学系数的影响

In addition, a two-dimernsion host molecular library of amide derivatives of tartaric acid was designed and synthesized.

本论文还设计合成了由20余个酒石酸酰胺衍生物组成的二维主体分子库，并对平行方法筛选主体分子作了一些初步的探索，发现主客体分子识别存在很强的专一性。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。